EA032935B1 - Состав для стабилизации полиэтилена, полиэтилен, способ его приготовления, полиэтиленовые имплантаты - Google Patents

Состав для стабилизации полиэтилена, полиэтилен, способ его приготовления, полиэтиленовые имплантаты

Info

Publication number
EA032935B1
EA032935B1 EA201700412A EA201700412A EA032935B1 EA 032935 B1 EA032935 B1 EA 032935B1 EA 201700412 A EA201700412 A EA 201700412A EA 201700412 A EA201700412 A EA 201700412A EA 032935 B1 EA032935 B1 EA 032935B1
Authority
EA
Eurasian Patent Office
Prior art keywords
polyethylene
stabilization
composition
implants
preparation
Prior art date
Application number
EA201700412A
Other languages
English (en)
Other versions
EA201700412A1 (ru
Inventor
Зденек Крулис
Мирослав Слоуф
Хайнек Бенес
Яна Коварова
Данусе Михалкова
Мартина Неворалова
Original Assignee
Устав Макромолекуларни Чемие Ав Цр, В.В.И.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Устав Макромолекуларни Чемие Ав Цр, В.В.И. filed Critical Устав Макромолекуларни Чемие Ав Цр, В.В.И.
Publication of EA201700412A1 publication Critical patent/EA201700412A1/ru
Publication of EA032935B1 publication Critical patent/EA032935B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/005—Stabilisers against oxidation, heat, light, ozone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0058—Biocides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/20—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
    • C08K5/39—Thiocarbamic acids; Derivatives thereof, e.g. dithiocarbamates
    • C08K5/40—Thiurams, i.e. compounds containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение предусматривает состав для стабилизации полиэтилена, состоящий из первого компонента, выбираемого из группы, содержащей токоферолы, токотриенолы и их смеси, и второго компонента, в качестве которого используют антибиотик из группы тетрациклинов. Кроме того, изобретение предусматривает полиэтилен, содержащий указанную смесь, предпочтительно в количестве не менее 200 ppm, способы его производства, а также имплантаты для применения в медицине или ветеринарии, содержащие названный стабилизированный полиэтилен.
EA201700412A 2015-04-21 2016-04-11 Состав для стабилизации полиэтилена, полиэтилен, способ его приготовления, полиэтиленовые имплантаты EA032935B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2015-267A CZ2015267A3 (cs) 2015-04-21 2015-04-21 Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
PCT/CZ2016/050010 WO2016169536A1 (en) 2015-04-21 2016-04-11 Composition for stabilization of polyethylene, polyethylene, method of preparation thereof, polyethylene implants

Publications (2)

Publication Number Publication Date
EA201700412A1 EA201700412A1 (ru) 2018-03-30
EA032935B1 true EA032935B1 (ru) 2019-08-30

Family

ID=55968853

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700412A EA032935B1 (ru) 2015-04-21 2016-04-11 Состав для стабилизации полиэтилена, полиэтилен, способ его приготовления, полиэтиленовые имплантаты

Country Status (6)

Country Link
EP (1) EP3285817B1 (ru)
CZ (1) CZ2015267A3 (ru)
EA (1) EA032935B1 (ru)
PT (1) PT3285817T (ru)
UA (1) UA120639C2 (ru)
WO (1) WO2016169536A1 (ru)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060223905A1 (en) * 2005-03-31 2006-10-05 Zimmer Technology, Inc. Liquid bath annealing of polymers for orthopaedic implants
WO2007019874A1 (en) * 2005-08-18 2007-02-22 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
WO2010129514A2 (en) * 2009-05-04 2010-11-11 Smith & Nephew, Inc. Synergistic effects of blending multiple additives in uhmwpe
CN104288162A (zh) * 2014-05-29 2015-01-21 郑州百瑞动物药业有限公司 一种奶牛用盐酸多西环素子宫注入剂及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA256129A (en) 1925-12-08 The Aluminum Company Of America Apparatus for electrolytic refining
CS221404B1 (cs) 1981-12-23 1983-04-29 Bretislav Dolezel Způsob stabilizace polyolefinů pro dosažení zvýšené odolnosti proti biologické degradaci v organismu
US5827904A (en) 1996-09-27 1998-10-27 Hahn; David Medical implant composition
EP0995449A1 (de) 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
SE9900519D0 (sv) 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
AU2004206826B8 (en) 2003-01-16 2009-03-26 Cambridge Polymer Group, Inc. Methods for making oxidation resistant polymeric material
JP5248107B2 (ja) 2004-05-11 2013-07-31 ザ、ジェネラル、ホスピタル、コーポレイション 耐酸化性重合体状材料の製造方法
RU2495054C2 (ru) 2008-05-13 2013-10-10 Смит Энд Нефью Ортопедикс Аг Устойчивый к окислению высокосшитый сверхвысокомолекулярный полиэтилен

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060223905A1 (en) * 2005-03-31 2006-10-05 Zimmer Technology, Inc. Liquid bath annealing of polymers for orthopaedic implants
WO2007019874A1 (en) * 2005-08-18 2007-02-22 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
WO2010129514A2 (en) * 2009-05-04 2010-11-11 Smith & Nephew, Inc. Synergistic effects of blending multiple additives in uhmwpe
CN104288162A (zh) * 2014-05-29 2015-01-21 郑州百瑞动物药业有限公司 一种奶牛用盐酸多西环素子宫注入剂及其制备方法

Also Published As

Publication number Publication date
UA120639C2 (uk) 2020-01-10
CZ2015267A3 (cs) 2016-11-09
EP3285817B1 (en) 2019-06-12
EP3285817A1 (en) 2018-02-28
WO2016169536A1 (en) 2016-10-27
EA201700412A1 (ru) 2018-03-30
PT3285817T (pt) 2019-09-06

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