EA028605B1 - Комбинация озельтамивира и ингибитора mek для лечения вирусных заболеваний - Google Patents
Комбинация озельтамивира и ингибитора mek для лечения вирусных заболеваний Download PDFInfo
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- EA028605B1 EA028605B1 EA201590703A EA201590703A EA028605B1 EA 028605 B1 EA028605 B1 EA 028605B1 EA 201590703 A EA201590703 A EA 201590703A EA 201590703 A EA201590703 A EA 201590703A EA 028605 B1 EA028605 B1 EA 028605B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- oseltamivir
- mek
- virus
- pharmaceutically acceptable
- Prior art date
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Applications Claiming Priority (3)
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| PCT/EP2013/070917 WO2014056894A1 (en) | 2012-10-08 | 2013-10-08 | Mek inhibitors in the treatment of virus diseases |
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| EA201590703A1 EA201590703A1 (ru) | 2015-07-30 |
| EA028605B1 true EA028605B1 (ru) | 2017-12-29 |
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| WO (1) | WO2014056894A1 (enExample) |
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| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| BR112015007616B1 (pt) * | 2012-10-08 | 2022-08-09 | Atriva Therapeutics Gmbh | Uso de inibidores de mek em combinação com oseltamivir, e composição farmacêutica e seu uso |
| KR102405136B1 (ko) | 2014-05-16 | 2022-06-07 | 아트리바 테라퓨틱스 게엠베하 | 인플루엔자 바이러스 및 에스. 아우레우스 공감염에 대한 신규한 항-감염 전략 |
| JPWO2018030534A1 (ja) * | 2016-08-10 | 2019-06-13 | 国立研究開発法人理化学研究所 | Ｂ型肝炎治療用組成物、及びｂ型肝炎ウイルスの複製活性の評価方法 |
| CA3041561A1 (en) * | 2016-11-25 | 2018-05-31 | Jiangsu Hengrui Medicine Co., Ltd. | Pyridone derivative pharmaceutical composition and preparation method thereof |
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| HRP20211252T1 (hr) | 2017-10-17 | 2021-11-12 | Atriva Therapeutics Gmbh | Novi mek-inhibitor za liječenje virusnih i bakterijskih infekcija |
| US20190298669A1 (en) * | 2018-03-29 | 2019-10-03 | Atriva Therapeutics Gmbh | Ci-1040 for the treatment of viral diseases |
| WO2020070390A1 (en) | 2018-10-03 | 2020-04-09 | Jyväskylän Yliopisto | Vemurafenib and salts thereof for use in the treatment of enteroviral infections |
| CN109765324B (zh) * | 2018-11-27 | 2021-03-30 | 苏州科技大学 | 一种mek1蛋白潜在抑制剂的筛选方法 |
| CA3133044A1 (en) | 2019-03-19 | 2020-09-24 | Atriva Therapeutics Gmbh | Rsk inhibitors in the treatment of virus diseases |
| LU101183B1 (en) | 2019-04-16 | 2020-10-16 | Atriva Therapeutics Gmbh | Novel mek-inhibitor for the treatment of viral and bacterial infections |
| CN114667138A (zh) * | 2019-08-27 | 2022-06-24 | 归属疗法有限公司 | Mek抑制剂与帽状结构依赖型核酸内切酶抑制剂的组合 |
| CN114786659B (zh) * | 2019-10-08 | 2025-02-14 | 归属疗法有限公司 | 用于治疗汉坦病毒感染的mek抑制剂 |
| WO2021214296A1 (en) * | 2020-04-24 | 2021-10-28 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Treatment of corona virus infections |
| CN111494620A (zh) * | 2020-05-05 | 2020-08-07 | 华中科技大学同济医学院附属协和医院 | 曲美替尼在制备疫苗中的应用 |
| CN111529532A (zh) * | 2020-05-05 | 2020-08-14 | 华中科技大学同济医学院附属协和医院 | 曲美替尼在制备治疗肺部炎症性疾病药物及促进Tfh细胞分化药物中的应用 |
| CN112137994B (zh) * | 2020-09-15 | 2022-10-14 | 中山大学 | 小分子化合物在制备抗丝状病毒药物中的应用 |
Citations (2)
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| WO2009140853A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Hong Kong | Combination therapy for the treatment of influenza |
| US20100137431A1 (en) * | 2000-04-07 | 2010-06-03 | Stephan Ludwig | Use of substances that act as cascade inhibitors of the raf/mek/erk signal cascade, for producing a medicament to treat dna and rna viruses |
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| DE69131667D1 (de) | 1990-07-30 | 1999-11-04 | Procyon Pharm Inc | Proteinkinase-c-modulatoren mit entzündungshemmender und antiviraler aktivität |
| US5866601A (en) | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
| US5763483A (en) | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| WO2000040237A1 (en) * | 1999-01-07 | 2000-07-13 | Warner-Lambert Company | Antiviral method using mek inhibitors |
| DE10138912A1 (de) | 2001-08-08 | 2003-02-27 | Medinnova Ges Med Innovationen | Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen |
| DK2395004T3 (en) * | 2005-06-22 | 2016-03-21 | Plexxikon Inc | Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors |
| BR112015007616B1 (pt) * | 2012-10-08 | 2022-08-09 | Atriva Therapeutics Gmbh | Uso de inibidores de mek em combinação com oseltamivir, e composição farmacêutica e seu uso |
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2013
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- 2013-10-08 EP EP13788684.2A patent/EP2903649A1/en not_active Withdrawn
- 2013-10-08 AU AU2013328824A patent/AU2013328824B2/en not_active Ceased
- 2013-10-08 KR KR1020157010311A patent/KR102174576B1/ko active Active
- 2013-10-08 EA EA201590703A patent/EA028605B1/ru active IP Right Revival
- 2013-10-08 CN CN201380064116.5A patent/CN105101999B/zh active Active
- 2013-10-08 JP JP2015535058A patent/JP6294889B2/ja not_active Expired - Fee Related
- 2013-10-08 CN CN201810617076.7A patent/CN109276716B/zh active Active
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2017
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20100137431A1 (en) * | 2000-04-07 | 2010-06-03 | Stephan Ludwig | Use of substances that act as cascade inhibitors of the raf/mek/erk signal cascade, for producing a medicament to treat dna and rna viruses |
| WO2009140853A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Hong Kong | Combination therapy for the treatment of influenza |
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| "Vemurafenib B-raf Kinase Inhibitor Oncolytic", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, vol. 36, no. 3, 1 January 2011 (2011-01-01), ES, pages 191 - 199, XP007922458, ISSN: 0377-8282, DOI: 10.1358/dof.2011.36.3.1590788 * |
| HSING-PANG HSIEH, JOHN HSU: "Strategies of Development of Antiviral Agents Directed Against Influenza Virus Replication", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, vol. 13, no. 34, 1 December 2007 (2007-12-01), pages 3531 - 3542, XP055093630, ISSN: 13816128, DOI: 10.2174/138161207782794248 * |
| KAROLINE DROEBNER; STEPHAN PLESCHKA; STEPHAN LUDWIG; OLIVER PLANZ;: "Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virusand", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 92, no. 2, 3 August 2011 (2011-08-03), NL, pages 195 - 203, XP028325598, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2011.08.002 * |
| S. LUDWIG: "Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, OXFORD UNIVERSITY PRESS, vol. 64, no. 1, 1 July 2009 (2009-07-01), pages 1 - 4, XP055093636, ISSN: 03057453, DOI: 10.1093/jac/dkp161 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201590703A1 (ru) | 2015-07-30 |
| CN105101999A (zh) | 2015-11-25 |
| BR112015007616A2 (pt) | 2017-08-08 |
| US20150224103A1 (en) | 2015-08-13 |
| JP2015534562A (ja) | 2015-12-03 |
| KR102174576B1 (ko) | 2020-11-06 |
| US9566281B2 (en) | 2017-02-14 |
| JP2018118971A (ja) | 2018-08-02 |
| AU2013328824B2 (en) | 2018-04-05 |
| CN105101999B (zh) | 2018-07-17 |
| BR112015007616B1 (pt) | 2022-08-09 |
| CA2886138A1 (en) | 2014-04-17 |
| CN109276716B (zh) | 2021-06-08 |
| CA2886138C (en) | 2021-10-12 |
| KR20150097464A (ko) | 2015-08-26 |
| EP2903649A1 (en) | 2015-08-12 |
| CN109276716A (zh) | 2019-01-29 |
| WO2014056894A1 (en) | 2014-04-17 |
| AU2013328824A1 (en) | 2015-04-30 |
| US20170209450A1 (en) | 2017-07-27 |
| JP6294889B2 (ja) | 2018-03-14 |
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