DOP2009000055A - NEW ANTI-CD38 ANTIBODIES FOR CANCER TREATMENT - Google Patents
NEW ANTI-CD38 ANTIBODIES FOR CANCER TREATMENTInfo
- Publication number
- DOP2009000055A DOP2009000055A DO2009000055A DO2009000055A DOP2009000055A DO P2009000055 A DOP2009000055 A DO P2009000055A DO 2009000055 A DO2009000055 A DO 2009000055A DO 2009000055 A DO2009000055 A DO 2009000055A DO P2009000055 A DOP2009000055 A DO P2009000055A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- antibodies
- cytotoxic
- conjugates
- treatment
- fragments
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Anticuerpos, anticuerpos humanizados, anticuerpos con supeficie modificada, fragmentos de anticuerpo, anticuerpos derivatizados, y conjugados de los mismos con agentes citotóxicos, que se unen especificamente a CDC38, son capaces de destruir las células CD38+ por apoptosis, citotoxicidad mediada por las células dependiente del anticuerpo (ADCC), y/o citotoxicidad dependiente del complemento (ACDC). Dichos anticuerpos y fragmentos de los mismos se pueden usar en el tratamiento de tumores que expresan niveles elevsados de proteína CD38, tales como mieloma múltiple, leucemia linfocitica crónica, leucemia mielógena crónica , leucemia mielógena aguda, o leucemia linfocitica aguda, o en el tratamiento de enfermedades autoinmunes e inflamatorias tales como lupus eritematoso sistématico, artritis reumatoide, esclerosis múltiple y asma. Dichos anticuerpos derivatizados se pueden usar en la diagnosis y diagnóstico por imagen de tumores que expresan niveles elevados de CD38. Tambien se proporcionan conjugados citotóxicos que comprenden un agente de unión a las células y un agente citotóxico, composiciones terapéuticas que comprenden el conjugado, métodos para usar los conjugados en la inhibición del crecimiento celular y en el tratamiento de la enfermedad, y un kit que comprende el conjugado citotóxico. En particular, el agente de unión a las células es un anticuerpo monoclonal, y los fragmjentos de éste que se unen al epítolo, que reconoce y se une a la proteína CD38.Antibodies, humanized antibodies, modified surface antibodies, antibody fragments, derivatized antibodies, and conjugates thereof with cytotoxic agents, which specifically bind to CDC38, are capable of destroying CD38 + cells by apoptosis, cell-mediated cytotoxicity dependent on antibody (ADCC), and / or complement dependent cytotoxicity (ACDC). Such antibodies and fragments thereof can be used in the treatment of tumors expressing elevated levels of CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or in the treatment of autoimmune and inflammatory diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and asthma. Such derivatized antibodies can be used in the diagnosis and diagnostic imaging of tumors expressing elevated levels of CD38. Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and in the treatment of the disease, and a kit comprising are also provided. the cytotoxic conjugate. In particular, the cell binding agent is a monoclonal antibody, and the fragments thereof that bind to the epitolus, which recognizes and binds to the CD38 protein.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2009000055A DOP2009000055A (en) | 2009-03-30 | 2009-03-30 | NEW ANTI-CD38 ANTIBODIES FOR CANCER TREATMENT |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DO2009000055A DOP2009000055A (en) | 2009-03-30 | 2009-03-30 | NEW ANTI-CD38 ANTIBODIES FOR CANCER TREATMENT |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2009000055A true DOP2009000055A (en) | 2009-06-30 |
Family
ID=44261559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2009000055A DOP2009000055A (en) | 2009-03-30 | 2009-03-30 | NEW ANTI-CD38 ANTIBODIES FOR CANCER TREATMENT |
Country Status (1)
Country | Link |
---|---|
DO (1) | DOP2009000055A (en) |
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2009
- 2009-03-30 DO DO2009000055A patent/DOP2009000055A/en unknown
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