AR122052A2 - THERAPEUTIC ANTIBODIES AND THEIR USES - Google Patents

THERAPEUTIC ANTIBODIES AND THEIR USES

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Publication number
AR122052A2
AR122052A2 ARP210101277A ARP210101277A AR122052A2 AR 122052 A2 AR122052 A2 AR 122052A2 AR P210101277 A ARP210101277 A AR P210101277A AR P210101277 A ARP210101277 A AR P210101277A AR 122052 A2 AR122052 A2 AR 122052A2
Authority
AR
Argentina
Prior art keywords
antibodies
bcma
specifically bind
antigen
conjugates
Prior art date
Application number
ARP210101277A
Other languages
Spanish (es)
Inventor
Tracy Chia Kuo
- Haparro Riggers Javier Fernando Chien
Wei Chen
Amy Shaw Chen
- Pascua Edward Derrick Ru
Blarcom Thomas John Van
Leila Marie Boustany
Weihsien Ho
Yik Andy Yeung
Pavel Strop
Arvind Rajpal
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR122052A2 publication Critical patent/AR122052A2/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con anticuerpos, por ejemplo, anticuerpos de longitud completa o fragmentos de unión al antígeno del mismo, que se unen específicamente a BCMA (Antígeno de Maduración de Células B) y CD3 (Agrupación de Diferenciación 3). La invención también se relaciona con conjugados de anticuerpo (por ejemplo, conjugados de anticuerpo-fármaco) que comprende los anticuerpos de BCMA, composiciones que comprenden los anticuerpos de BCMA, y métodos para utilizar los anticuerpos de BCMA y sus conjugados para tratar padecimientos asociados con células que expresan BCMA (por ejemplo, cáncer o enfermedad autoinmune). La invención se relaciona aún más con anticuerpos heteromultiméricos que se unen específicamente a CD3 y un antígeno de célula de tumor, (por ejemplo, anticuerpos biespecíficos que se unen específicamente a CD3 y BCMA). También se proporcionan composiciones que comprenden tales anticuerpos heteromultiméricos, métodos para producir y purificar tales anticuerpos heterodiméricos, y su uso en el diagnóstico y en agentes terapéuticos.The present invention relates to antibodies, eg, full-length antibodies or antigen-binding fragments thereof, that specifically bind to BCMA (B Cell Maturation Antigen) and CD3 (Differentiation Cluster 3). The invention also relates to antibody conjugates (eg, antibody-drug conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates to treat conditions associated with BCMA. BCMA-expressing cells (eg, cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (eg, bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods of producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutic agents are also provided.

ARP210101277A 2015-04-13 2021-05-10 THERAPEUTIC ANTIBODIES AND THEIR USES AR122052A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562146504P 2015-04-13 2015-04-13

Publications (1)

Publication Number Publication Date
AR122052A2 true AR122052A2 (en) 2022-08-10

Family

ID=59256470

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP160100864A AR104152A1 (en) 2015-04-13 2016-03-31 THERAPEUTIC ANTIBODIES AND THEIR USES
ARP210101277A AR122052A2 (en) 2015-04-13 2021-05-10 THERAPEUTIC ANTIBODIES AND THEIR USES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP160100864A AR104152A1 (en) 2015-04-13 2016-03-31 THERAPEUTIC ANTIBODIES AND THEIR USES

Country Status (1)

Country Link
AR (2) AR104152A1 (en)

Also Published As

Publication number Publication date
AR104152A1 (en) 2017-06-28

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