La presente invencion se refiere a anticuerpos y porciones que ligan antigeno del mismo que se liga especificamente a un M-CSF, preferentemente MCSF human, y que funciona para inhibir al M-CSF. La invencion tambien se refiere a anticuerpos anti-M-CSF humanos y porciones que ligan antigen de los mismos. La invencion tambien se refiere a anticuerpos que son quimericos, biespecificos, derivatizados, anticuerpos de cadena simple o porciones de proteinas de fusion. La invencion tambien se refiere a inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-M-CSF humanos y a moleculas de acido nucleico que codifican tales inmunoglobulinas. La presente invencion tambien se refiere a metodos para fabricar anticuerpos anti-M-CSF humanos, a composiciones que comprenden estos anticuerpos y a metodos para usar los anticuerpos y composiciones para diagnostico y tratamiento. La invencion tambien provee metodos de terapia con genes que usan moleculas de acido nucleico que codifican la cadena pesada y/o liviana de moleculas de inmunoglobulina que comprenden los anticuerpos anti-M-CSF humanos. La invencion tambien se refiere a animales transgenicos y plantas transgenicas que comprenden moleculas de acido nucleico de la presente invencion.The present invention relates to antibodies and antigen binding portions thereof that specifically binds to an M-CSF, preferably human MCSF, and that functions to inhibit M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods for making human anti-M-CSF antibodies, to compositions comprising these antibodies and to methods for using antibodies and compositions for diagnosis and treatment. The invention also provides methods of gene therapy using nucleic acid molecules that encode the heavy and / or light chain of immunoglobulin molecules comprising human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention.