La presente invencion se refiere a anticuerpos que incluyen anticuerpos humanos y porciones que ligan antigeno de los mismos que se ligan especificamente a c-Met, preferentemente a c-Met humano y que funcionan para inhibir c-Met. La invencion tambien se refiere a anticuerpos anti-c-Met humanos y porciones que ligan antigeno de los mismos. La invencion tambien se refiere a anticuerpos que son quimerico, biespectficos, derivatizados, anticuerpos de cadena simple o porciones de proteinas de fusion. La invencion tambien se refiere a inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-c-Met humanos y a moleculas de acido nucleico que codifican tales inmunoglobulinas. La presente invencion tambien se refiere a metodos para fabricar anticuerpos anti-c-Met humanos, composiciones que comprenden estos anticuerpos y a metodos para usar los anticuerpos y composiciones para diagnostico y tratamiento. La invencion tambien provee metodos de terapia con genes que usan moleculas de acido nucleico que codifican las moleculas de inmunoglobulina y/o liviana que comprende los anticuerpos anti-c-Met humanos. La invencion tambien se refiere a animales o plantas transgenicos que comprenden moleculas de acido nucleico de la presente invencion.The present invention relates to antibodies that include human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably to human c-Met and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods for making human anti-c-Met antibodies, compositions comprising these antibodies and methods for using antibodies and compositions for diagnosis and treatment. The invention also provides methods of gene therapy using nucleic acid molecules that encode immunoglobulin and / or light molecules comprising human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.