DOP2004000953A -
INDAZOL COMPOUNDS 3,5-DISPOSED, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT THE CELL PROLIFERATION.
- Google Patents
INDAZOL COMPOUNDS 3,5-DISPOSED, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT THE CELL PROLIFERATION.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PfizerfiledCriticalPfizer
Priority to DO2004000953ApriorityCriticalpatent/DOP2004000953A/en
Publication of DOP2004000953ApublicationCriticalpatent/DOP2004000953A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Plural Heterocyclic Compounds
(AREA)
Abstract
Se describen compuestos de indazol 3,5-disustituidos que modulan y/o inhiben la proliferation celular tal como la actividad de las proteinas cinasa. Estos compuestos y composiciones farmaceuticas que los contienen son capaces de intervenir en enfermedades dependientes de la CDK para modular y/o inhibir la proliferacion celular no deseada. La invencion tambien se dirige al use terapautico o profilactico de composiciones farmaceuticas que contienen tales compuestos y a metodos para tratar el cancer asi como otras condiciones patologicas asociadas con angiogenesis y/o proliferacion celular, no deseada, tales como: retinopatia diabatica, glaucoma neovascular, artritis reumatoide y soriasis, por administration de cantidades eficaces de tales compuestos.3,5-Disubstituted indazole compounds that modulate and / or inhibit cell proliferation such as kinase protein activity are described. These compounds and pharmaceutical compositions containing them are capable of intervening in diseases dependent on CDK to modulate and / or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds and methods for treating cancer as well as other pathological conditions associated with angiogenesis and / or unwanted cell proliferation, such as: diabetic retinopathy, neovascular glaucoma, arthritis rheumatoid and psoriasis, by administration of effective amounts of such compounds.
DO2004000953A2004-07-162004-07-16
INDAZOL COMPOUNDS 3,5-DISPOSED, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT THE CELL PROLIFERATION.
DOP2004000953A
(en)
Pyrazole compounds for protein kinase inhibition, pharmaceutically acceptable salt and prodrug, pharmaceutically active metabolite or pharmaceutically acceptable salt of metabolite, pharmaceutical composition, method of treating disease in mammals mediated by protein kinase activity, modulation or inhibition method of the activity of a protein kinase receptor
COMPOUNDS DERIVED FROM ACID 6- (2-BROMOFENIL) -PIRIDO [2,3-DIPIRIMIDIN-7-CARBOXILICO; PHARMACEUTICAL COMPOSITION; PREPARATION PROCEDURE; AND USE TO TREAT CANCER AND TO PREPARE MEDICATIONS TO INHIBIT TUMOR GROWTH.