DK645389A - Phosphinsyresubstituerede steroider, farmaceutiske midler indeholdende disse samt deres anvendelse - Google Patents
Phosphinsyresubstituerede steroider, farmaceutiske midler indeholdende disse samt deres anvendelse Download PDFInfo
- Publication number
- DK645389A DK645389A DK645389A DK645389A DK645389A DK 645389 A DK645389 A DK 645389A DK 645389 A DK645389 A DK 645389A DK 645389 A DK645389 A DK 645389A DK 645389 A DK645389 A DK 645389A
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical agents
- agents containing
- substituted steroids
- phosphic acid
- phosphic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/290,212 US5026882A (en) | 1988-12-23 | 1988-12-23 | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
Publications (2)
Publication Number | Publication Date |
---|---|
DK645389D0 DK645389D0 (da) | 1989-12-19 |
DK645389A true DK645389A (da) | 1990-06-24 |
Family
ID=23114995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK645389A DK645389A (da) | 1988-12-23 | 1989-12-19 | Phosphinsyresubstituerede steroider, farmaceutiske midler indeholdende disse samt deres anvendelse |
Country Status (13)
Country | Link |
---|---|
US (1) | US5026882A (de) |
EP (1) | EP0375349B1 (de) |
JP (1) | JPH02215796A (de) |
AT (1) | ATE110735T1 (de) |
AU (1) | AU630139B2 (de) |
CA (1) | CA2005214A1 (de) |
DE (1) | DE68917884T2 (de) |
DK (1) | DK645389A (de) |
ES (1) | ES2059789T3 (de) |
HU (1) | HU205137B (de) |
IE (1) | IE894111L (de) |
PT (1) | PT92723A (de) |
ZA (1) | ZA899671B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US4970204A (en) * | 1989-08-23 | 1990-11-13 | Smithkline Beecham Corporation | 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors |
US5516768A (en) * | 1990-03-16 | 1996-05-14 | Smithkline Beecham Corporation | Uncompetitive inhibition of steroid and 5α-reductose |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
CH681153A5 (de) * | 1991-01-28 | 1993-01-29 | Marigen S.A. | Neue sterolester- und sterolphosphorverbindungen. |
IL101243A (en) * | 1991-03-20 | 1999-12-22 | Merck & Co Inc | Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
ES2148229T3 (es) * | 1992-05-20 | 2000-10-16 | Merck & Co Inc | Eteres y tioeteres en la posicion 17 de 4-aza-esteroides. |
WO1993023041A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | Ester derivatives of 4-aza-steroids |
WO1993023420A1 (en) * | 1992-05-20 | 1993-11-25 | Merck & Co., Inc. | NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS |
DE69326008T2 (de) * | 1992-05-20 | 2000-03-02 | Merck & Co Inc | 17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren |
SK137994A3 (en) * | 1992-05-20 | 1995-04-12 | Merck & Co Inc | 7-beta-substituted-4-aza-5-alpha-cholestan-ons their using for production of pharmaceutical agent and pharmaceutical agent containing them |
EP0641208B1 (de) * | 1992-05-20 | 2000-08-02 | Merck & Co. Inc. | 4-azasteroide als 5-alpha-reduktase |
EP0641211A1 (de) * | 1992-05-21 | 1995-03-08 | Endorecherche Inc. | Testosteron-5-alpha-reduktase-inhibitonen |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
WO1994021614A1 (en) * | 1993-03-24 | 1994-09-29 | Merck & Co., Inc. | SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS |
DE69405760T2 (de) * | 1993-06-28 | 1998-04-09 | Merck & Co Inc | 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
EP1067939B1 (de) * | 1998-04-09 | 2015-09-16 | The Johns Hopkins University | Verwendung von steroidalkaloidderivaten als inhibitoren der hedgehog-protein signalwege |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
EP1728797A3 (de) | 1999-10-13 | 2011-03-02 | Johns Hopkins University School of Medicine | Regulatoren des Hedgehog-Wegs, ihre Zusammensetzungen un Verwendungen |
EP1889198B1 (de) | 2005-04-28 | 2014-11-26 | Proteus Digital Health, Inc. | Pharma-informatiksystem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
EP2427178B1 (de) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
CA1252778A (en) * | 1983-08-25 | 1989-04-18 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Steroids |
US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
US4937237A (en) * | 1988-12-23 | 1990-06-26 | Smithkline Beckman Corporation | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
US4946834A (en) * | 1988-12-23 | 1990-08-07 | Smithkline Beecham Corporation | Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
-
1988
- 1988-12-23 US US07/290,212 patent/US5026882A/en not_active Expired - Fee Related
-
1989
- 1989-10-11 HU HU895286A patent/HU205137B/hu not_active IP Right Cessation
- 1989-12-12 CA CA002005214A patent/CA2005214A1/en not_active Abandoned
- 1989-12-18 ZA ZA899671A patent/ZA899671B/xx unknown
- 1989-12-19 EP EP89313262A patent/EP0375349B1/de not_active Expired - Lifetime
- 1989-12-19 DE DE68917884T patent/DE68917884T2/de not_active Expired - Fee Related
- 1989-12-19 DK DK645389A patent/DK645389A/da not_active Application Discontinuation
- 1989-12-19 ES ES89313262T patent/ES2059789T3/es not_active Expired - Lifetime
- 1989-12-19 AT AT89313262T patent/ATE110735T1/de not_active IP Right Cessation
- 1989-12-20 AU AU47039/89A patent/AU630139B2/en not_active Ceased
- 1989-12-20 IE IE894111A patent/IE894111L/xx unknown
- 1989-12-22 JP JP1334672A patent/JPH02215796A/ja active Pending
- 1989-12-22 PT PT92723A patent/PT92723A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU205137B (en) | 1992-03-30 |
DE68917884T2 (de) | 1995-03-23 |
EP0375349B1 (de) | 1994-08-31 |
AU630139B2 (en) | 1992-10-22 |
CA2005214A1 (en) | 1990-06-23 |
US5026882A (en) | 1991-06-25 |
DE68917884D1 (de) | 1994-10-06 |
HUT55795A (en) | 1991-06-28 |
AU4703989A (en) | 1990-06-28 |
ATE110735T1 (de) | 1994-09-15 |
IE894111L (en) | 1990-06-23 |
HU895286D0 (en) | 1990-01-28 |
EP0375349A1 (de) | 1990-06-27 |
PT92723A (pt) | 1990-06-29 |
ES2059789T3 (es) | 1994-11-16 |
ZA899671B (en) | 1990-11-28 |
JPH02215796A (ja) | 1990-08-28 |
DK645389D0 (da) | 1989-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |