DK641489A - Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n epimerase (racemase) aktivitet - Google Patents

Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n epimerase (racemase) aktivitet Download PDF

Info

Publication number
DK641489A
DK641489A DK641489A DK641489A DK641489A DK 641489 A DK641489 A DK 641489A DK 641489 A DK641489 A DK 641489A DK 641489 A DK641489 A DK 641489A DK 641489 A DK641489 A DK 641489A
Authority
DK
Denmark
Prior art keywords
racemase
epimerase
activity
expression vectors
isopenicillin
Prior art date
Application number
DK641489A
Other languages
Danish (da)
English (en)
Other versions
DK641489D0 (da
Inventor
Steven Kovacevic
James Robert Miller
Paul Luther Skatrud
Matthew Barry Tobin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK641489D0 publication Critical patent/DK641489D0/da
Publication of DK641489A publication Critical patent/DK641489A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK641489A 1988-12-22 1989-12-18 Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n epimerase (racemase) aktivitet DK641489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28876088A 1988-12-22 1988-12-22

Publications (2)

Publication Number Publication Date
DK641489D0 DK641489D0 (da) 1989-12-18
DK641489A true DK641489A (da) 1990-06-23

Family

ID=23108528

Family Applications (1)

Application Number Title Priority Date Filing Date
DK641489A DK641489A (da) 1988-12-22 1989-12-18 Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n epimerase (racemase) aktivitet

Country Status (12)

Country Link
EP (1) EP0377295B1 (de)
JP (1) JPH02227082A (de)
AT (1) ATE118042T1 (de)
AU (1) AU622253B2 (de)
CA (1) CA2005649A1 (de)
DE (1) DE68920987T2 (de)
DK (1) DK641489A (de)
ES (1) ES2067556T3 (de)
GR (1) GR3015473T3 (de)
HU (1) HU208713B (de)
IE (1) IE894168L (de)
IL (1) IL92740A0 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94651A0 (en) * 1989-06-12 1991-04-15 Univ Oklahoma State Purified enzyme and process therefor
IL97000A0 (en) * 1990-01-26 1992-03-29 Lilly Co Eli Recombinant dna expression vectors and dna compounds that encode isopenicillin n epimerase activity
WO1996010084A1 (en) * 1994-09-28 1996-04-04 Novo Nordisk A/S Process for the production of secondary metabolites
FR2744455B1 (fr) * 1996-02-02 1998-04-24 Sanofi Sa Nouvelles sequences d'acides nucleiques de la famille des facteurs suppresseurs de tumeurs, produits d'expression correspondants et leurs applications
US7294459B1 (en) 1997-10-15 2007-11-13 President And Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
US7030227B1 (en) 1997-10-15 2006-04-18 President & Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
US8956833B2 (en) 2010-05-07 2015-02-17 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
JP6280367B2 (ja) 2010-08-31 2018-02-14 グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. プロテアーゼ操作を介した代謝経路におけるフラックスの制御のための方法
CN104093848A (zh) 2011-09-09 2014-10-08 绿光生物科学公司 碳青霉烯(carbapenem)的无细胞制备
CN105658807A (zh) 2013-08-05 2016-06-08 绿光生物科技股份有限公司 具有蛋白酶切割位点的工程化蛋白
SG11201707370WA (en) 2015-03-30 2017-10-30 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
KR102536687B1 (ko) 2016-04-06 2023-05-25 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
MX2020003841A (es) 2017-10-11 2020-11-06 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT42665A (en) * 1984-11-21 1987-07-28 Medicor Muevek Device for adjusting parameters of exposition of a x-ray apparatus

Also Published As

Publication number Publication date
HU896734D0 (en) 1990-02-28
IE894168L (en) 1990-06-22
EP0377295B1 (de) 1995-02-01
HU208713B (en) 1993-12-28
DK641489D0 (da) 1989-12-18
DE68920987T2 (de) 1995-06-22
DE68920987D1 (de) 1995-03-16
JPH02227082A (ja) 1990-09-10
GR3015473T3 (en) 1995-06-30
ATE118042T1 (de) 1995-02-15
CA2005649A1 (en) 1990-06-22
EP0377295A1 (de) 1990-07-11
IL92740A0 (en) 1990-09-17
HUT53149A (en) 1990-09-28
ES2067556T3 (es) 1995-04-01
AU4709889A (en) 1990-06-28
AU622253B2 (en) 1992-04-02

Similar Documents

Publication Publication Date Title
DK641489A (da) Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n epimerase (racemase) aktivitet
DK217889A (da) Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for desacetoxycephalosporin c synthetase
DE3686397D1 (de) Kovalent gebundene polypeptid enthaltende zellmodulatoren.
AU4814885A (en) Modified tissue plasminogen activator produced by recombinant DNA
NO864569L (no) Modifiserte fibrinolyttiske midler.
DK135488A (da) Il-3-protein, isaer humant il-3, dets fremstilling og anvendelse i farmaceutica, vektor, som koder proteinet, samt celler transformeret med vektoren
DK561886D0 (da) Rekombinante dna-udtrykkelsesvektorer og dna-forbindelser, der indkoder isopenicillin n synthetase fra penicillium chrysogenum
EP0246307A4 (de) Durch cys-kodon modifizierte dns.
FI905660A (fi) Nya polypeptider, dna-sekvenser som moejliggoer deras expression, foerfarande foer framstaellning och anvaendning.
DK178386D0 (da) Rekombinant dna-udtrykkelsesvektor og dna-forbindelser, der udtrykker isopenicillin n synthetase
DK102088A (da) Rekombinant-dna-udtrykkelsesvektorer og dna-produkter, der koder deacetoxycephalosporin c syntetase og deacetylsephalosporin c synthetase
DK0444775T3 (da) Rekombinant-DNA-ekspressionsvektorer og DNA-forbindelser, som koder for isopenicillin-N-epimerase-ak tivitet
DK606088D0 (da) Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for isopenicillin n synthetase
DE68922891D1 (de) D-Aminosäureoxidase.
DE58908428D1 (de) Sekretormutante von Escherichia coli.
FR2681076B1 (fr) Adn recombinant codant pour une proteine a activite endochitinase.
ATE189479T1 (de) Expressionsvektoren zur synthese von proteinen in der spalthefe schizosaccharomyces pombe
DK260188D0 (da) Enzymproduktion
DK0422790T3 (da) Rekombinant DNA-ekspressionsvektorer og DNA-forbindelser der koder for acyltransferaseaktivitet fra Aspergillus
EP0222726A3 (de) Mutierte codierende Sequenz
AR245956A1 (es) Vector de adn, cepa bacteriana que lo contiene y metodo para modificar geneticamente una celula vegetal
NO178704C (no) DNA-sekvens som koder for protein med IRF-1-aktivitet, ekspresjonsvektor inneholdende denne, anvendelse av IRF-1 for å öke ekspresjon, vertscelle transformert med ekspresjonsvektoren, og protein med IRF-1-aktivitet
IE880604L (en) Dna sequence encoding dacs/daocs activity of cephalosporium

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment