DK634389A - Peptid, dets fremstilling og anvendelse til paavisning af hiv-protease - Google Patents

Peptid, dets fremstilling og anvendelse til paavisning af hiv-protease Download PDF

Info

Publication number
DK634389A
DK634389A DK634389A DK634389A DK634389A DK 634389 A DK634389 A DK 634389A DK 634389 A DK634389 A DK 634389A DK 634389 A DK634389 A DK 634389A DK 634389 A DK634389 A DK 634389A
Authority
DK
Denmark
Prior art keywords
thr
hiv protease
ile
val
peptid
Prior art date
Application number
DK634389A
Other languages
Danish (da)
English (en)
Other versions
DK634389D0 (da
Inventor
Karin Moelling
Stephan Henke
Gerhard Breipohl
Wolfgang Koenig
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK634389D0 publication Critical patent/DK634389D0/da
Publication of DK634389A publication Critical patent/DK634389A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK634389A 1988-12-15 1989-12-14 Peptid, dets fremstilling og anvendelse til paavisning af hiv-protease DK634389A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3842197A DE3842197A1 (de) 1988-12-15 1988-12-15 Rasch spaltbares substrat fuer die hiv-protease

Publications (2)

Publication Number Publication Date
DK634389D0 DK634389D0 (da) 1989-12-14
DK634389A true DK634389A (da) 1990-06-16

Family

ID=6369209

Family Applications (1)

Application Number Title Priority Date Filing Date
DK634389A DK634389A (da) 1988-12-15 1989-12-14 Peptid, dets fremstilling og anvendelse til paavisning af hiv-protease

Country Status (16)

Country Link
US (1) US5093477A (ja)
EP (1) EP0373576B1 (ja)
JP (1) JPH02207097A (ja)
KR (1) KR900009694A (ja)
AT (1) ATE120205T1 (ja)
AU (1) AU4614889A (ja)
CA (1) CA2005516A1 (ja)
DE (2) DE3842197A1 (ja)
DK (1) DK634389A (ja)
ES (1) ES2070886T3 (ja)
FI (1) FI895950A0 (ja)
GR (1) GR3015740T3 (ja)
IL (1) IL92687A0 (ja)
NO (1) NO895027L (ja)
PT (1) PT92574A (ja)
ZA (1) ZA899556B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428000A1 (en) * 1989-11-03 1991-05-22 Abbott Laboratories Fluorogenic substrates for the detection of proteolytic enzyme activity
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
CA2130754C (en) * 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
DE69837393T2 (de) * 1997-09-29 2007-12-06 Point Therapeutics, Inc., Boston Stimulierung von hämatopoietischen zellen im vitro
KR20010052302A (ko) 1998-05-04 2001-06-25 바바라 피. 월너 조혈 자극
PT1084129E (pt) 1998-06-05 2003-06-30 Point Therapeutics Inc Compostos de boroprolina ciclica
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
CA2491466A1 (en) * 2002-07-09 2004-01-15 Sharlene Adams Methods and compositions relating to isoleucine boroproline compounds
US20060063719A1 (en) * 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293591C (en) * 1985-01-11 1991-12-24 Charles A. Kettner Peptide substrates for detecting virus-specified protease activity
DE3643012A1 (de) * 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3736589A1 (de) * 1987-10-29 1989-05-11 Behringwerke Ag Glutaminhaltige peptide, verfahren zu deren herstellung und verwendung
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease

Also Published As

Publication number Publication date
DE3842197A1 (de) 1990-06-21
JPH02207097A (ja) 1990-08-16
NO895027L (no) 1990-06-18
ATE120205T1 (de) 1995-04-15
EP0373576B1 (de) 1995-03-22
FI895950A0 (fi) 1989-12-13
PT92574A (pt) 1990-06-29
EP0373576A2 (de) 1990-06-20
KR900009694A (ko) 1990-07-05
NO895027D0 (no) 1989-12-14
DK634389D0 (da) 1989-12-14
US5093477A (en) 1992-03-03
ZA899556B (en) 1990-09-26
DE58909130D1 (de) 1995-04-27
IL92687A0 (en) 1990-09-17
EP0373576A3 (en) 1990-10-31
CA2005516A1 (en) 1990-06-15
GR3015740T3 (en) 1995-07-31
AU4614889A (en) 1990-06-21
ES2070886T3 (es) 1995-06-16

Similar Documents

Publication Publication Date Title
DK634389D0 (da) Peptid, dets fremstilling og anvendelse til paavisning af hiv-protease
ATE108438T1 (de) Urethan geschützte aminosäuren-n- carboxyanhydride.
NO174395C (no) Flytende rensemiddelblanding og fremgangsmåte for fremstilling av denne
DK150992A (da) Fremgangsmaade til fremstilling af et polypeptidfragment af faktor viii:c, dna-sekvens og ekstrachromosomalt element indeholdende en saadan dna-sekvens, som koder herfor
DK332684A (da) Modificerede protease-inhibitorer samt deres fremstilling og anvendelse
NO882946L (no) Konstruksjon av syntetisk dna og anvendelse derav i syntese av store polypeptider.
NO834128L (no) Nye derivater av tricykliske aminosyrer, fremgangsmaate til deres fremstilling, midler som inneholder disse, og deres anvendelse, samt nye bicykliske aminosyrer som mellomprodukter og fremgangsmaate til deres fremstilling
DK135887A (da) Human-vaevstype-plasminogenaktivator-polypeptider og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
ZA899559B (en) Use of peptide isosteres as retroviral protease inhibitors
DK372086A (da) Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved
DK627488A (da) Fremgangsmaade til fremstilling af bionedbrydelige mikrokapsler af vandoploeselige peptider og proteiner samt ved denne fremgangsmaade opnaaede mikrokapsler
DK568287A (da) Relativt lavmolekylaere peptider og deres anvendelse som renininhibitorer
DK0583338T3 (da) Fremgangsmåde til syntese af peptider, hidtil ukendte aminosyrederivater anvendt i denne fremgangsmåde og fremgangsmåder til deres fremstilling
DK0463053T3 (da) Fremstilling og anvendelse af anthelmintiske midler og beskyttende immunogener
NO892744D0 (no) N-terminale aminodiol-aminosyrederivater og fremgangsmaatefor deres fremstilling.
DK0496327T3 (da) Polypetider med prourokinaseaktivitet, for disse kodende plasmider og fremgangsmåder til deres fremstilling og deres anvendelse
KR890012001A (ko) 사람 α2-플라스민 억제제 또는 이와 유사한 단백질로 부터 유도된 단백질
NO982227D0 (no) Urogenitalcarcinom-TPL komplekspeptider og antistoffer derav
ATE46173T1 (de) Pharmakologisch aktive peptide.
DK185087A (da) Kromofore peptider, deres fremstilling og anvendelse til paavisning af den peptidylglycin-alfa-amiderende monooxygenase, samt ved fremstillingen anvendelige mellemprodukter
IT1231149B (it) Uso di enzima pam nella sintesi in fase solida dei peptidi.
DK362288A (da) Homocyclostatin- og cyclostatinholdige peptider og farmaceutiske praeparater indeholdende disse
TH13932EX (th) "การตรวจภูมิคุ้มกันสำหรับการค้นหาพร้อมๆ กันของแอนตี้บอดี้เอชไอวี-1, เอชไอวี-2, เอชทีแอลวี-i และเอชทีแอลวี-ii"
IE894012L (en) Use of peptide isosteres as retroviral protease inhibitors

Legal Events

Date Code Title Description
ATS Application withdrawn