DK589589A - PURE-INHIBITIVE AMINODIOL DERIVATIVES, THEIR PREPARATION AND USE - Google Patents

PURE-INHIBITIVE AMINODIOL DERIVATIVES, THEIR PREPARATION AND USE

Info

Publication number
DK589589A
DK589589A DK589589A DK589589A DK589589A DK 589589 A DK589589 A DK 589589A DK 589589 A DK589589 A DK 589589A DK 589589 A DK589589 A DK 589589A DK 589589 A DK589589 A DK 589589A
Authority
DK
Denmark
Prior art keywords
inhibitive
pure
preparation
aminodiol derivatives
radical
Prior art date
Application number
DK589589A
Other languages
Danish (da)
Other versions
DK589589D0 (en
Inventor
Rainer Henning
Hansjoerg Urbach
Dieter Ruppert
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK589589D0 publication Critical patent/DK589589D0/en
Publication of DK589589A publication Critical patent/DK589589A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to compounds of the formula I <IMAGE> in which A is a radical of the formula II <IMAGE> in which E is a CH2 group or a radical NR<9>, G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<9> are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.
DK589589A 1988-11-24 1989-11-23 PURE-INHIBITIVE AMINODIOL DERIVATIVES, THEIR PREPARATION AND USE DK589589A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839559A DE3839559A1 (en) 1988-11-24 1988-11-24 RENIN-INHIBITING AMINODIOL DERIVATIVES

Publications (2)

Publication Number Publication Date
DK589589D0 DK589589D0 (en) 1989-11-23
DK589589A true DK589589A (en) 1990-05-25

Family

ID=6367727

Family Applications (1)

Application Number Title Priority Date Filing Date
DK589589A DK589589A (en) 1988-11-24 1989-11-23 PURE-INHIBITIVE AMINODIOL DERIVATIVES, THEIR PREPARATION AND USE

Country Status (16)

Country Link
EP (1) EP0370454B1 (en)
JP (1) JPH02193968A (en)
KR (1) KR900007867A (en)
AT (1) ATE104678T1 (en)
AU (1) AU628109B2 (en)
DE (2) DE3839559A1 (en)
DK (1) DK589589A (en)
ES (1) ES2054989T3 (en)
FI (1) FI93645C (en)
HU (1) HU204262B (en)
IL (1) IL92405A0 (en)
NO (1) NO177351C (en)
NZ (1) NZ231485A (en)
PH (1) PH27267A (en)
PT (1) PT92388B (en)
ZA (1) ZA898990B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839128A1 (en) * 1988-11-19 1990-05-31 Hoechst Ag RENIN-INHIBITING DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
CA2018801C (en) * 1990-06-12 2000-08-22 Pierre Louis Beaulieu Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
DE4021007A1 (en) * 1990-07-02 1992-01-09 Hoechst Ag Amino diol DERIVATIVES
PL294870A1 (en) * 1991-06-21 1993-02-08 Hoechst Ag

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
ATE165085T1 (en) * 1987-09-29 1998-05-15 Banyu Pharma Co Ltd N-ACYLAMINOSIC ACID DERIVATIVES AND USE THEREOF
IL90184A0 (en) * 1988-05-09 1989-12-15 Abbott Lab Functionalized peptidyl aminodiols and-triols

Also Published As

Publication number Publication date
FI93645B (en) 1995-01-31
FI93645C (en) 1995-05-10
PH27267A (en) 1993-05-04
HUT52524A (en) 1990-07-28
PT92388A (en) 1990-05-31
ZA898990B (en) 1990-08-29
NO894663L (en) 1990-05-25
EP0370454A2 (en) 1990-05-30
EP0370454B1 (en) 1994-04-20
JPH02193968A (en) 1990-07-31
HU896173D0 (en) 1990-02-28
NO894663D0 (en) 1989-11-23
NZ231485A (en) 1993-03-26
DE58907505D1 (en) 1994-05-26
HU204262B (en) 1991-12-30
AU4547589A (en) 1990-09-13
EP0370454A3 (en) 1990-10-24
DK589589D0 (en) 1989-11-23
FI895568A0 (en) 1989-11-22
ES2054989T3 (en) 1994-08-16
IL92405A0 (en) 1990-07-26
NO177351B (en) 1995-05-22
KR900007867A (en) 1990-06-02
PT92388B (en) 1995-07-18
ATE104678T1 (en) 1994-05-15
DE3839559A1 (en) 1990-05-31
AU628109B2 (en) 1992-09-10
NO177351C (en) 1995-08-30

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Legal Events

Date Code Title Description
ATS Application withdrawn