AU4547589A - Renin-inhibiting aminodiol derivatives - Google Patents

Renin-inhibiting aminodiol derivatives

Info

Publication number
AU4547589A
AU4547589A AU45475/89A AU4547589A AU4547589A AU 4547589 A AU4547589 A AU 4547589A AU 45475/89 A AU45475/89 A AU 45475/89A AU 4547589 A AU4547589 A AU 4547589A AU 4547589 A AU4547589 A AU 4547589A
Authority
AU
Australia
Prior art keywords
renin
inhibiting
radical
formula
aminodiol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU45475/89A
Other versions
AU628109B2 (en
Inventor
Rainer Henning
Dieter Ruppert
Bernward Scholkens
Hansjorg Urbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4547589A publication Critical patent/AU4547589A/en
Application granted granted Critical
Publication of AU628109B2 publication Critical patent/AU628109B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to compounds of the formula I <IMAGE> in which A is a radical of the formula II <IMAGE> in which E is a CH2 group or a radical NR<9>, G is a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B is an amino acid, D is a heterocycle, and R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<9> are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to the use thereof as medicines.
AU45475/89A 1988-11-24 1989-11-24 Renin-inhibiting aminodiol derivatives Ceased AU628109B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3839559 1988-11-24
DE3839559A DE3839559A1 (en) 1988-11-24 1988-11-24 RENIN-INHIBITING AMINODIOL DERIVATIVES

Publications (2)

Publication Number Publication Date
AU4547589A true AU4547589A (en) 1990-09-13
AU628109B2 AU628109B2 (en) 1992-09-10

Family

ID=6367727

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45475/89A Ceased AU628109B2 (en) 1988-11-24 1989-11-24 Renin-inhibiting aminodiol derivatives

Country Status (16)

Country Link
EP (1) EP0370454B1 (en)
JP (1) JPH02193968A (en)
KR (1) KR900007867A (en)
AT (1) ATE104678T1 (en)
AU (1) AU628109B2 (en)
DE (2) DE3839559A1 (en)
DK (1) DK589589A (en)
ES (1) ES2054989T3 (en)
FI (1) FI93645C (en)
HU (1) HU204262B (en)
IL (1) IL92405A0 (en)
NO (1) NO177351C (en)
NZ (1) NZ231485A (en)
PH (1) PH27267A (en)
PT (1) PT92388B (en)
ZA (1) ZA898990B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641629B2 (en) * 1988-11-23 1993-09-30 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
US5284849A (en) * 1990-05-11 1994-02-08 Abbott Laboratories Renin inhibitors

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839128A1 (en) * 1988-11-19 1990-05-31 Hoechst Ag RENIN-INHIBITING DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
CA2018801C (en) * 1990-06-12 2000-08-22 Pierre Louis Beaulieu Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus
DE4021007A1 (en) * 1990-07-02 1992-01-09 Hoechst Ag Amino diol DERIVATIVES
PL294870A1 (en) * 1991-06-21 1993-02-08 Hoechst Ag

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
EP0309766B1 (en) * 1987-09-29 1998-04-15 Banyu Pharmaceutical Co., Ltd. N-acylamino acid derivatives and their use
IL90184A0 (en) * 1988-05-09 1989-12-15 Abbott Lab Functionalized peptidyl aminodiols and-triols

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641629B2 (en) * 1988-11-23 1993-09-30 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
US5284849A (en) * 1990-05-11 1994-02-08 Abbott Laboratories Renin inhibitors
US5310740A (en) * 1990-05-11 1994-05-10 Abbott Laboratories Renin inhibitors

Also Published As

Publication number Publication date
ATE104678T1 (en) 1994-05-15
FI895568A0 (en) 1989-11-22
DE58907505D1 (en) 1994-05-26
DK589589A (en) 1990-05-25
DK589589D0 (en) 1989-11-23
FI93645C (en) 1995-05-10
JPH02193968A (en) 1990-07-31
PT92388B (en) 1995-07-18
HU896173D0 (en) 1990-02-28
IL92405A0 (en) 1990-07-26
HUT52524A (en) 1990-07-28
NO177351B (en) 1995-05-22
PT92388A (en) 1990-05-31
NO894663D0 (en) 1989-11-23
NZ231485A (en) 1993-03-26
PH27267A (en) 1993-05-04
EP0370454A2 (en) 1990-05-30
EP0370454B1 (en) 1994-04-20
KR900007867A (en) 1990-06-02
NO177351C (en) 1995-08-30
FI93645B (en) 1995-01-31
EP0370454A3 (en) 1990-10-24
HU204262B (en) 1991-12-30
AU628109B2 (en) 1992-09-10
NO894663L (en) 1990-05-25
DE3839559A1 (en) 1990-05-31
ZA898990B (en) 1990-08-29
ES2054989T3 (en) 1994-08-16

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