DK587986A - Konjugater af vinblastin eller derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende dem - Google Patents

Konjugater af vinblastin eller derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende dem

Info

Publication number
DK587986A
DK587986A DK587986A DK587986A DK587986A DK 587986 A DK587986 A DK 587986A DK 587986 A DK587986 A DK 587986A DK 587986 A DK587986 A DK 587986A DK 587986 A DK587986 A DK 587986A
Authority
DK
Denmark
Prior art keywords
vinblastin
conjugates
procedures
derivatives
producing
Prior art date
Application number
DK587986A
Other languages
English (en)
Other versions
DK587986D0 (da
Inventor
Jean Alfred Alphonse Hannart
Andre Benoit Leon Trouet
Kandukuri Sivaprasada Bush Rao
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU86212A external-priority patent/LU86212A1/fr
Priority claimed from LU86515A external-priority patent/LU86515A1/xx
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of DK587986D0 publication Critical patent/DK587986D0/da
Publication of DK587986A publication Critical patent/DK587986A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
DK587986A 1985-12-16 1986-12-08 Konjugater af vinblastin eller derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende dem DK587986A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU86212A LU86212A1 (fr) 1985-12-16 1985-12-16 Nouveaux conjugues de la vinblastine et de ses derives,procede pour leur preparation et compositions pharmaceutiques les contenant
LU86515A LU86515A1 (da) 1986-07-16 1986-07-16

Publications (2)

Publication Number Publication Date
DK587986D0 DK587986D0 (da) 1986-12-08
DK587986A true DK587986A (da) 1987-06-17

Family

ID=26640313

Family Applications (1)

Application Number Title Priority Date Filing Date
DK587986A DK587986A (da) 1985-12-16 1986-12-08 Konjugater af vinblastin eller derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende dem

Country Status (8)

Country Link
US (2) US4828831A (da)
EP (1) EP0232693A3 (da)
DK (1) DK587986A (da)
HU (1) HU198075B (da)
IE (1) IE863266L (da)
IL (1) IL80914A (da)
NZ (1) NZ218619A (da)
PT (1) PT83896B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
US5556623A (en) * 1993-03-30 1996-09-17 Eli Lilly And Company Antibody-drug conjugates
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US7097839B1 (en) * 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
DE19636889A1 (de) 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6319894B1 (en) * 1997-01-08 2001-11-20 The Picower Institute For Medical Research Complexes and combinations of fetuin with therapeutic agents
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU1374601A (en) * 1999-11-12 2001-05-30 Angiotech International Ag Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
FI820020L (fi) * 1981-01-12 1982-07-13 Lilly Industries Ltd Immunoglobulinkonjugater
CA1203164A (en) * 1982-03-09 1986-04-15 Thomas J. Mckearn Antibody conjugates
JPS59116229A (ja) * 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
US4596676A (en) * 1983-03-30 1986-06-24 Lilly Industries Limited Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids
DE3482444D1 (de) * 1983-03-30 1990-07-19 Lilly Industries Ltd Immunoglobulinkonjugate.
ATE64396T1 (de) * 1983-04-29 1991-06-15 Omnichem Sa Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant

Also Published As

Publication number Publication date
US4828831A (en) 1989-05-09
IL80914A0 (en) 1987-03-31
AU6653786A (en) 1987-06-18
IE863266L (en) 1987-06-16
NZ218619A (en) 1989-09-27
DK587986D0 (da) 1986-12-08
PT83896B (pt) 1989-01-17
EP0232693A3 (fr) 1988-04-06
PT83896A (fr) 1987-01-01
AU592136B2 (en) 1990-01-04
EP0232693A2 (fr) 1987-08-19
US5030620A (en) 1991-07-09
HU198075B (en) 1989-07-28
HUT45264A (en) 1988-06-28
IL80914A (en) 1991-08-16

Similar Documents

Publication Publication Date Title
DK587986D0 (da) Konjugater af vinblastin eller derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende dem
DK340785A (da) Quinonderivater, fremgangsmaade til fremstilling af dem og farmaceutisk praeparat indeholdende dem
DK539789D0 (da) Carbostyrilderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant carbostyrilderivat
DK56086D0 (da) 11beta-phenylgonaner, deres fremstilling og farmaceutiske praeparaterindeholdende dem
DK162445C (da) Pyranopyridiner, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende pyranopyridinerne
DK163923C (da) 2-phenyl-3-aminomethyl-imidazooe1,2-aaapyridinderivater og farmaceutisk praeparat indeholdende saadanne forbindelser
DK218985A (da) Aminocyklopentylaetere, farmaceutiske praeparater indeholdende dem og fremgangsmaade til fremstilling af dem
DK438788D0 (da) Alkylaminoalkoxyphenylderivater, fremgangsmaade til deres fremstilling og midler indeholdende dem
DK165006C (da) Kromoglycinsyrederivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat
DK504986D0 (da) 7-acylbenzoxazinoner og deres derivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem
DK183986D0 (da) Cyklopentylaetere, fremgangsmaade til fremstilling deraf og laegemiddelpraeparat indeholdende saadanne forbindelser
DK612788A (da) Alkoxyderivater af ginkolider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK262186A (da) Quinolinderivater, farmaceutisk praeparat indeholdende saadanne forbindelser og fremgangsmaade til fremstilling deraf
DK347789D0 (da) Cysteinderivater, fremgangsmaade til fremstilling af dem og farmaceutiske praeparater indeholdende saadanne forbindelser
DK525187A (da) Imidazooe4,5-baapyridinon-2-derivater, fremgangsmaade til fremstilling af og laegemidler indeholdende saadanne derivater
DK457386D0 (da) 4-substituerede catechol-derivater, fremgangsmaade til fremstillingderaf og farmaceutiske praeparater indeholdende saadanne derivater
DK9086D0 (da) Naphthalenderivater af benzonorbornen, fremgangsmaade til deres fremstilling og laegemidler og kosmetikpraeparater indeholdende saadanne forbindelser
DK575387A (da) Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser
DK392187A (da) Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
DK315487A (da) Methylenderivater af androst-4-en-3,17-dioner og fremgangsmaade til fremstilling deraf
DK465585D0 (da) Nukleosidderivater, farmaceutiske praeparater indeholdende dem og fremgangsmaade til fremstilling af dem
DK163826C (da) 1,4-dihydro-3-carboxy-6,8-difluor-4-oxoquinolin-derivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne derivater
DK616087D0 (da) Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
DK158985C (da) 2h-azetooe2,1-aaa-isoquinolinderivater og farmaceutiske praeparater indeholdende dem
DK612888D0 (da) Octahydro-indenofuranderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende saadanne forbindelser

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment