DK580188A - EXPRESSION PLASMID, E.COLI VALVE CELL AND OXSE-SOMATOTROPIN LIKE POLYPEPTIDE - Google Patents

EXPRESSION PLASMID, E.COLI VALVE CELL AND OXSE-SOMATOTROPIN LIKE POLYPEPTIDE

Info

Publication number
DK580188A
DK580188A DK580188A DK580188A DK580188A DK 580188 A DK580188 A DK 580188A DK 580188 A DK580188 A DK 580188A DK 580188 A DK580188 A DK 580188A DK 580188 A DK580188 A DK 580188A
Authority
DK
Denmark
Prior art keywords
oxse
somatotropin
coli
polypeptide
expression plasmid
Prior art date
Application number
DK580188A
Other languages
Danish (da)
Other versions
DK580188D0 (en
Inventor
Che-Shen Chiu Tomich
Eric R Olson
John E Mott
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK580188D0 publication Critical patent/DK580188D0/en
Publication of DK580188A publication Critical patent/DK580188A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C07K14/592—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH] at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Abstract

Novel species of cDNAs encoding somatotropins, novel dual replicon vectors, hosts for such vectors and hosts for expressing the somatotropins encoded by such cDNAs.
DK580188A 1987-02-19 1988-10-18 EXPRESSION PLASMID, E.COLI VALVE CELL AND OXSE-SOMATOTROPIN LIKE POLYPEPTIDE DK580188A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1629487A 1987-02-19 1987-02-19
PCT/US1988/000328 WO1988006186A2 (en) 1987-02-19 1988-01-27 cDNAs ENCODING SOMATOTROPIN, EXPRESSION VECTORS AND HOSTS

Publications (2)

Publication Number Publication Date
DK580188D0 DK580188D0 (en) 1988-10-18
DK580188A true DK580188A (en) 1988-10-18

Family

ID=21776383

Family Applications (1)

Application Number Title Priority Date Filing Date
DK580188A DK580188A (en) 1987-02-19 1988-10-18 EXPRESSION PLASMID, E.COLI VALVE CELL AND OXSE-SOMATOTROPIN LIKE POLYPEPTIDE

Country Status (9)

Country Link
EP (1) EP0418219B1 (en)
JP (1) JP2580303B2 (en)
KR (1) KR960016704B1 (en)
AT (1) ATE107696T1 (en)
AU (1) AU615432B2 (en)
DE (1) DE3850410T2 (en)
DK (1) DK580188A (en)
HK (1) HK65497A (en)
WO (1) WO1988006186A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104806A (en) * 1987-03-12 1992-04-14 Amgen, Inc. Porcine growth hormone analogs encoding dna
EP0398983A1 (en) * 1988-01-27 1990-11-28 The Upjohn Company Expression vectors
US5268284A (en) * 1988-03-11 1993-12-07 The Upjohn Company Ribosome binding site
WO1990005186A1 (en) * 1988-11-04 1990-05-17 The Upjohn Company Somatotropin expression using a serratia promoter
DK0514405T3 (en) * 1990-01-31 1995-07-10 Upjohn Co Strain RAL-4 useful for the preparation of small proteins and peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201918A (en) * 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
EP0111814A3 (en) * 1982-12-16 1985-08-14 Mgi Pharma, Inc. The cloning and expression of nucleotide sequences encoding bovine growth hormone
GB8308236D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Dna vectors
JPS6011557A (en) * 1983-04-19 1985-01-21 ジエネツクス・コ−ポレイシヨン Clone sheep growth hormone gene
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
AU557486B2 (en) * 1984-01-27 1986-12-24 Monsanto Company Composition for improved bovine feeding and milk production
US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields
DE3585170D1 (en) * 1984-03-06 1992-02-27 Lilly Co Eli EXPRESSION VECTORS FOR BOVINE GROWTH HORMON DERIVATIVES.
DE68929273T2 (en) * 1988-08-24 2001-07-05 American Cyanamid Co Stabilization of somatotropins through modification of cysteine residues through site-specific mutagenesis or chemical derivatization

Also Published As

Publication number Publication date
DK580188D0 (en) 1988-10-18
ATE107696T1 (en) 1994-07-15
KR960016704B1 (en) 1996-12-20
KR890700663A (en) 1989-04-26
AU615432B2 (en) 1991-10-03
DE3850410D1 (en) 1994-07-28
AU1363988A (en) 1988-09-14
JPH02502245A (en) 1990-07-26
WO1988006186A3 (en) 1988-11-03
WO1988006186A2 (en) 1988-08-25
JP2580303B2 (en) 1997-02-12
DE3850410T2 (en) 1994-10-27
HK65497A (en) 1997-05-23
EP0418219A1 (en) 1991-03-27
EP0418219B1 (en) 1994-06-22

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