SE8800981A - A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR - Google Patents

A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR

Info

Publication number
SE8800981A
SE8800981A SE8800981A SE8800981A SE8800981A SE 8800981 A SE8800981 A SE 8800981A SE 8800981 A SE8800981 A SE 8800981A SE 8800981 A SE8800981 A SE 8800981A SE 8800981 A SE8800981 A SE 8800981A
Authority
SE
Sweden
Prior art keywords
recombinant
fusion protein
recombinant vector
vector
recombinant fusion
Prior art date
Application number
SE8800981A
Other languages
Swedish (sv)
Other versions
SE8800981D0 (en
Inventor
Lars Abrahamsen
Mathias Uhlen
Per-Aake Nygren
Original Assignee
Lars Abrahamsen
Mathias Uhlen
Aake Nygren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lars Abrahamsen, Mathias Uhlen, Aake Nygren filed Critical Lars Abrahamsen
Priority to SE8800981A priority Critical patent/SE8800981A/en
Publication of SE8800981D0 publication Critical patent/SE8800981D0/en
Publication of SE8800981A publication Critical patent/SE8800981A/en
Priority to EP89850091A priority patent/EP0333691A3/en
Priority to JP6234689A priority patent/JPH0242990A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A recombinant fusion protein comprising a desired protein, oligo- or polypeptide flanked by affinity fragments or moieties, each capable of selective binding; recombinant vector, process for purifying and isolating a desired protein; and a host organism transformed by the recombinant vector.
SE8800981A 1988-03-17 1988-03-17 A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR SE8800981A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE8800981A SE8800981A (en) 1988-03-17 1988-03-17 A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR
EP89850091A EP0333691A3 (en) 1988-03-17 1989-03-16 A recombinant fusion protein, its use and a recombinant vector
JP6234689A JPH0242990A (en) 1988-03-17 1989-03-16 Recombinant fused protein and recombinant vector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8800981A SE8800981A (en) 1988-03-17 1988-03-17 A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR

Publications (2)

Publication Number Publication Date
SE8800981D0 SE8800981D0 (en) 1988-03-17
SE8800981A true SE8800981A (en) 1988-10-14

Family

ID=20371731

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8800981A SE8800981A (en) 1988-03-17 1988-03-17 A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR

Country Status (3)

Country Link
EP (1) EP0333691A3 (en)
JP (1) JPH0242990A (en)
SE (1) SE8800981A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595887A (en) * 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
JPH04126092A (en) * 1990-09-14 1992-04-27 Nippon Kayaku Co Ltd Removing of protein derived from escherichia coli
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300693L (en) * 1983-02-09 1984-08-10 Sven Lofdahl SET TO MAKE AND ISOLATE PROTEINS AND POLYPEPTIDES, AND A HYBRID VECTOR FOR THIS
DE3410437A1 (en) * 1984-03-22 1985-09-26 Bayer Ag, 5090 Leverkusen PROCESS FOR PRODUCING PROTEINS
SE8505922D0 (en) * 1985-12-13 1985-12-13 Kabigen Ab CONSTRUCTION OF AN IGG BINDING PROTEIN TO FACILITATE DOWNSTREAM PROCESSING USING PROTEIN ENGINEERING
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine

Also Published As

Publication number Publication date
SE8800981D0 (en) 1988-03-17
EP0333691A2 (en) 1989-09-20
EP0333691A3 (en) 1990-08-08
JPH0242990A (en) 1990-02-13

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Ref document number: 8800981-6

Effective date: 19890629