DK567883A - TYLOSIN DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE - Google Patents

TYLOSIN DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE Download PDF

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Publication number
DK567883A
DK567883A DK567883A DK567883A DK567883A DK 567883 A DK567883 A DK 567883A DK 567883 A DK567883 A DK 567883A DK 567883 A DK567883 A DK 567883A DK 567883 A DK567883 A DK 567883A
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DK
Denmark
Prior art keywords
image
acyl
aralkyl
alkylaminomethyl
acyloxymethyl
Prior art date
Application number
DK567883A
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Danish (da)
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DK152924B (en
DK152924C (en
DK567883D0 (en
Inventor
Alan Keith Mallams
Ashit Kumar Ganguly
Yi-Tsung Liu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to DK567883A priority Critical patent/DK152924C/en
Publication of DK567883D0 publication Critical patent/DK567883D0/en
Publication of DK567883A publication Critical patent/DK567883A/en
Publication of DK152924B publication Critical patent/DK152924B/en
Application granted granted Critical
Publication of DK152924C publication Critical patent/DK152924C/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

23-Demycinosyltylosine derivatives of the general formula I: <IMAGE> in which R1 is H or acyl, R2 is acyl, R3 is H or acyl, or R2 and R3 are together a carbonyl group linking the 3" and 4" hydroxyl groups, R4 is H or acyl, R6 is methyl, hydroxymethyl, fluoromethyl, chloromethyl, bromomethyl, iodomethyl, di(C1-C6)-alkylaminomethyl or acyloxymethyl, CHO or a group CH=R5, and Z is an imino group R5 or can, when R6 is fluoromethyl, chloromethyl, bromomethyl, iodomethyl or acyloxymethyl, CHO or di(C1- C6)alkylaminomethyl, also be oxo, in connection with which R5 is N-NH-aralkyl, <IMAGE> or <IMAGE> (II) in which n is 0, 1 or 2, and Q is CH2, CHR7, CR7R8, NH, NR7, O, S, SO2, CHOH, CHOR7, CR7OH, CR7OR8, <IMAGE>, <IMAGE>, CHCOOH, CHCOOR7, CHCONH2 or <IMAGE>, in which R7 and R8 are, mutually independently, (C1-C6)alkyl, (C7- C10)aralkyl or (C6-C10)aryl including X-substituted aryl or aralkyl, where X is halogen, trifluoromethyl, (C1- C6)alkoxy or (C1-C6)alkylcarbonyl, and pharmaceutically acceptable salts thereof, are prepared by a number of different processes. The compounds possess broad-spectrum antibacterial activity.
DK567883A 1983-12-09 1983-12-09 20-IMINO-TYLOSIN SUBSTANCES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS DK152924C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK567883A DK152924C (en) 1983-12-09 1983-12-09 20-IMINO-TYLOSIN SUBSTANCES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK567883 1983-12-09
DK567883A DK152924C (en) 1983-12-09 1983-12-09 20-IMINO-TYLOSIN SUBSTANCES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS

Publications (4)

Publication Number Publication Date
DK567883D0 DK567883D0 (en) 1983-12-09
DK567883A true DK567883A (en) 1985-06-10
DK152924B DK152924B (en) 1988-05-30
DK152924C DK152924C (en) 1988-10-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK567883A DK152924C (en) 1983-12-09 1983-12-09 20-IMINO-TYLOSIN SUBSTANCES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS

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DK (1) DK152924C (en)

Also Published As

Publication number Publication date
DK152924B (en) 1988-05-30
DK152924C (en) 1988-10-24
DK567883D0 (en) 1983-12-09

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