DK565683A - METHOD OF PRODUCING ISOTRETINOIN - Google Patents

METHOD OF PRODUCING ISOTRETINOIN Download PDF

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Publication number
DK565683A
DK565683A DK565683A DK565683A DK565683A DK 565683 A DK565683 A DK 565683A DK 565683 A DK565683 A DK 565683A DK 565683 A DK565683 A DK 565683A DK 565683 A DK565683 A DK 565683A
Authority
DK
Denmark
Prior art keywords
palladium
rhodium
compound
isotretinoin
producing
Prior art date
Application number
DK565683A
Other languages
Danish (da)
Other versions
DK565683D0 (en
DK170945B1 (en
Inventor
Robert Lucci
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK565683D0 publication Critical patent/DK565683D0/en
Publication of DK565683A publication Critical patent/DK565683A/en
Application granted granted Critical
Publication of DK170945B1 publication Critical patent/DK170945B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)

Abstract

1. A process for the manufacture of 13-cis-retinoic acid, characterized by a) reacting 5-hydroxy-4-methyl-2(5H)-furanone with a salt of the formula see diagramm : EP0111325,P8,F1 wherein R1 , R2 and R3 are aryl or di-(lower-alkyl)-amino and X is halogen, in a lower alkanol in the presence of an alkali metal hydroxide at a temperature of -10 to -50 degrees C, and b) treating the reaction product obtained in step a) in an organic solvent with a compound or a complex of rhodium or palladium other than palladium or rhodium phthalocyanine or a palladium or rhodium compound containing a cyanide ion.
DK565683A 1982-12-10 1983-12-08 Process for Preparation of 13-Cisretinoic Acid and Process for Preparing a Palladium Catalyst for Use in the Process DK170945B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44866082A 1982-12-10 1982-12-10
US44866082 1982-12-10

Publications (3)

Publication Number Publication Date
DK565683D0 DK565683D0 (en) 1983-12-08
DK565683A true DK565683A (en) 1984-06-11
DK170945B1 DK170945B1 (en) 1996-03-25

Family

ID=23781154

Family Applications (1)

Application Number Title Priority Date Filing Date
DK565683A DK170945B1 (en) 1982-12-10 1983-12-08 Process for Preparation of 13-Cisretinoic Acid and Process for Preparing a Palladium Catalyst for Use in the Process

Country Status (5)

Country Link
EP (1) EP0111325B1 (en)
JP (1) JPS59116263A (en)
AT (1) ATE32217T1 (en)
DE (1) DE3375480D1 (en)
DK (1) DK170945B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313089A1 (en) * 1993-04-22 1994-10-27 Basf Ag Process for the preparation of 13-(Z)-retinoic acid
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same
IT1274494B (en) * 1995-05-12 1997-07-17 Lab Mag Spa PHOTOCHEMICAL PROCEDURE FOR THE PREPARATION OF 13-CIS-RETINOIC ACID
US6124485A (en) * 1998-03-25 2000-09-26 Abbott Laboratories Process for producing 13-cis retinoic acid
EP1564209A1 (en) * 2004-02-17 2005-08-17 Helsinn Advanced Synthesis SA Process for the preparation of 13-cis-retinoic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051174A (en) * 1973-08-21 1977-09-27 Hoffmann-La Roche Inc. Isomerization process

Also Published As

Publication number Publication date
DE3375480D1 (en) 1988-03-03
DK565683D0 (en) 1983-12-08
JPH0425263B2 (en) 1992-04-30
JPS59116263A (en) 1984-07-05
EP0111325A3 (en) 1985-07-03
EP0111325B1 (en) 1988-01-27
ATE32217T1 (en) 1988-02-15
DK170945B1 (en) 1996-03-25
EP0111325A2 (en) 1984-06-20

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed