ATE32217T1 - PROCESS FOR THE PREPARATION OF 13-CIS RETINOIC ACID. - Google Patents

PROCESS FOR THE PREPARATION OF 13-CIS RETINOIC ACID.

Info

Publication number
ATE32217T1
ATE32217T1 AT83112376T AT83112376T ATE32217T1 AT E32217 T1 ATE32217 T1 AT E32217T1 AT 83112376 T AT83112376 T AT 83112376T AT 83112376 T AT83112376 T AT 83112376T AT E32217 T1 ATE32217 T1 AT E32217T1
Authority
AT
Austria
Prior art keywords
palladium
retinoic acid
rhodium
preparation
cis retinoic
Prior art date
Application number
AT83112376T
Other languages
German (de)
Inventor
Robert Lucci
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE32217T1 publication Critical patent/ATE32217T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)

Abstract

1. A process for the manufacture of 13-cis-retinoic acid, characterized by a) reacting 5-hydroxy-4-methyl-2(5H)-furanone with a salt of the formula see diagramm : EP0111325,P8,F1 wherein R1 , R2 and R3 are aryl or di-(lower-alkyl)-amino and X is halogen, in a lower alkanol in the presence of an alkali metal hydroxide at a temperature of -10 to -50 degrees C, and b) treating the reaction product obtained in step a) in an organic solvent with a compound or a complex of rhodium or palladium other than palladium or rhodium phthalocyanine or a palladium or rhodium compound containing a cyanide ion.
AT83112376T 1982-12-10 1983-12-08 PROCESS FOR THE PREPARATION OF 13-CIS RETINOIC ACID. ATE32217T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44866082A 1982-12-10 1982-12-10
EP83112376A EP0111325B1 (en) 1982-12-10 1983-12-08 Process for the preparation of 13-cis-retinoic acid

Publications (1)

Publication Number Publication Date
ATE32217T1 true ATE32217T1 (en) 1988-02-15

Family

ID=23781154

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83112376T ATE32217T1 (en) 1982-12-10 1983-12-08 PROCESS FOR THE PREPARATION OF 13-CIS RETINOIC ACID.

Country Status (5)

Country Link
EP (1) EP0111325B1 (en)
JP (1) JPS59116263A (en)
AT (1) ATE32217T1 (en)
DE (1) DE3375480D1 (en)
DK (1) DK170945B1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313089A1 (en) * 1993-04-22 1994-10-27 Basf Ag Process for the preparation of 13-(Z)-retinoic acid
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same
IT1274494B (en) * 1995-05-12 1997-07-17 Lab Mag Spa PHOTOCHEMICAL PROCEDURE FOR THE PREPARATION OF 13-CIS-RETINOIC ACID
US6124485A (en) * 1998-03-25 2000-09-26 Abbott Laboratories Process for producing 13-cis retinoic acid
EP1564209A1 (en) * 2004-02-17 2005-08-17 Helsinn Advanced Synthesis SA Process for the preparation of 13-cis-retinoic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051174A (en) * 1973-08-21 1977-09-27 Hoffmann-La Roche Inc. Isomerization process

Also Published As

Publication number Publication date
JPS59116263A (en) 1984-07-05
DK170945B1 (en) 1996-03-25
DK565683D0 (en) 1983-12-08
DK565683A (en) 1984-06-11
EP0111325B1 (en) 1988-01-27
DE3375480D1 (en) 1988-03-03
EP0111325A2 (en) 1984-06-20
EP0111325A3 (en) 1985-07-03
JPH0425263B2 (en) 1992-04-30

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