DK507781A - Fremgangsmaade til fremstilling af hypocholesterolaemiske fermentationsprodukter - Google Patents

Fremgangsmaade til fremstilling af hypocholesterolaemiske fermentationsprodukter

Info

Publication number
DK507781A
DK507781A DK507781A DK507781A DK507781A DK 507781 A DK507781 A DK 507781A DK 507781 A DK507781 A DK 507781A DK 507781 A DK507781 A DK 507781A DK 507781 A DK507781 A DK 507781A
Authority
DK
Denmark
Prior art keywords
hypocholesterolaemic
procedure
preparation
fermentation products
compounds
Prior art date
Application number
DK507781A
Other languages
Danish (da)
English (en)
Inventor
V P Gullo
T Y K Lam
R L Monaghan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK507781A publication Critical patent/DK507781A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK507781A 1980-11-17 1981-11-16 Fremgangsmaade til fremstilling af hypocholesterolaemiske fermentationsprodukter DK507781A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/207,508 US4343814A (en) 1980-11-17 1980-11-17 Hypocholesterolemic fermentation products

Publications (1)

Publication Number Publication Date
DK507781A true DK507781A (da) 1982-05-18

Family

ID=22770879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK507781A DK507781A (da) 1980-11-17 1981-11-16 Fremgangsmaade til fremstilling af hypocholesterolaemiske fermentationsprodukter

Country Status (10)

Country Link
US (1) US4343814A (fr)
EP (1) EP0052366B1 (fr)
JP (1) JPS57122076A (fr)
AT (1) ATE8244T1 (fr)
DE (1) DE3164608D1 (fr)
DK (1) DK507781A (fr)
ES (1) ES8302091A1 (fr)
GR (1) GR76327B (fr)
IE (1) IE52159B1 (fr)
PT (1) PT73964B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS57144279A (en) * 1981-03-02 1982-09-06 Sankyo Co Ltd Dihydro ml-236b and dihydro mb-530b and derivative thereof
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
CA1327360C (fr) * 1983-11-14 1994-03-01 William F. Hoffman Analogues oxo d'agents antihypercholesterolemiants ayant les caracteristiques de la mevinoline
US4950775A (en) * 1985-10-11 1990-08-21 University Of California Antihypercholesterolemic compounds and synthesis thereof
US5208258A (en) * 1985-10-11 1993-05-04 The Regents Of The University Of California Antihypercholesterolemic compounds and synthesis thereof
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
CZ200450A3 (cs) 2001-06-13 2004-05-12 Ranbaxyálaboratoriesálimited Methylové analogy simvastatinu jako například nové inhibitory HMG@CoA reduktázy
BR112016010554A2 (pt) 2013-11-11 2017-08-08 Basf Se Linhagem de penicillium, extrato livre de células, meio de cultivo, ácido tanzawaico, método de preparação do ácido tanzawaico, composição, uso da linhagem, método de controle e semente ou muda de uma planta opcionalmente modificada geneticamente

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (fr) * 1974-06-07 1981-03-18
DE2748825C2 (de) * 1976-11-02 1986-11-27 Sankyo Co., Ltd., Tokio/Tokyo Substituierte 3,5-Dihydroxyheptansäurederivate und diese enthaltende Arzneimittel gegen Hyperlipämie
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4294846A (en) * 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives

Also Published As

Publication number Publication date
US4343814A (en) 1982-08-10
IE52159B1 (en) 1987-07-22
EP0052366B1 (fr) 1984-07-04
ATE8244T1 (de) 1984-07-15
ES507191A0 (es) 1983-01-01
GR76327B (fr) 1984-08-04
JPH046189B2 (fr) 1992-02-05
DE3164608D1 (en) 1984-08-09
JPS57122076A (en) 1982-07-29
PT73964B (en) 1984-08-01
EP0052366A1 (fr) 1982-05-26
ES8302091A1 (es) 1983-01-01
IE812671L (en) 1982-05-17
PT73964A (en) 1981-12-01

Similar Documents

Publication Publication Date Title
ES8105389A1 (es) Un procedimiento de produccion de productos de fermentacion hipocolesteremicos.
SE7506498L (sv) Forfarande for framstellning av fysiologiskt aktiva substanster.
KR910700228A (ko) 알디미노-또는 케티미노-옥시-오르토-톨릴아크릴산의 메틸 에스테르, 이의 제조방법 및 이를 함유하는 살진균제
FI892016A0 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten, mahdollisesti -substituoitujen 4-(-kinolin-2-yyli-metoksi)-fenyylietikkahappojen ja -esterien valmistamiseksi
OA05636A (fr) Procédé de transformation d'un ester d'acide chiral d'alcool secondaire -cyané optiquement actif de structure (R) en ester d'acide chiral d'alcool secondaire -cyané de structure (S), produits et compositions insecticides.
DK507781A (da) Fremgangsmaade til fremstilling af hypocholesterolaemiske fermentationsprodukter
DK453386D0 (da) Farmaceutisk praeparat indeholdende 2-(2-fluor-4-bifenylyl)-propionsyre eller et farmaceutisk acceptabelt salt deraf
FI890388A0 (fi) Menetelmä (S)-ketoprofeenin valmistamiseksi
DK137234B (da) Analogifremgangsmåde til fremstilling af racemisk eller optisk aktiv 1-isopropylamino-3-(4-(2-isopropylkarbamoylaminoætyl)-fenoxy)-propanol-2 eller syreadditionssalte deraf.
AU533355B2 (en) Organo-tin oxime derivatives
NO790621L (no) Pyrethroidinsekticider, cyclopropancarboxylsyrer og -estere som mellomprodukter for disse, samt fremgangsmaate for deres fremstilling
NO802540L (no) 4-(2`,2`,2`-trihalogenetyl)cyklobutan-1-sulfonsyresalter og fremgangsmaate til fremstilling av disse
JPS54144332A (en) Racemization of optically active 2-(4-chlorophenyl)-3- methylbutyric acid
IL59724A0 (en) Pentadecapeptide and its salts,their preparation and pharmaceutical compositions containing them
SE8001617L (sv) Forfarande for framstellning av ett karbazolderivat
JPS5692786A (en) Cultivation of microorganism
JPS56125338A (en) Phenylacetic acid derivative
FR2319709A1 (fr) Milieu, notamment pour la constitution de milieux de culture de micro-organismes
JPS55127993A (en) Preparation of koji acid
PT69235A (fr) Procede de preparation de nouvelles compositions pharmaceutiques a base d'enzyme bacterien
JPS5417183A (en) Preparation of l-glutamic acid
JPS56147733A (en) Optically active alcoholic compound and its preparation
JPS5359646A (en) Novel process for preparation of insecticides
JPS55115869A (en) Novel caboxylic ester, its preparation, and insecticide and acaricide comprising it
FR2429773A1 (fr) Nouveau derive de l'acide acetylsalicylique, procede d'obtention de celui-ci et composition pharmaceutique en comportant application

Legal Events

Date Code Title Description
ATS Application withdrawn