DK487683A - Fremgangsmaade til fremstilling af 7-oxabicycloheptan-substituerede amino-prostaglandinanaloge - Google Patents
Fremgangsmaade til fremstilling af 7-oxabicycloheptan-substituerede amino-prostaglandinanaloge Download PDFInfo
- Publication number
- DK487683A DK487683A DK487683A DK487683A DK487683A DK 487683 A DK487683 A DK 487683A DK 487683 A DK487683 A DK 487683A DK 487683 A DK487683 A DK 487683A DK 487683 A DK487683 A DK 487683A
- Authority
- DK
- Denmark
- Prior art keywords
- oxabicycloheptan
- preparing
- procedure
- substituted amino
- prostaglandin analogue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/436,741 US4456615A (en) | 1982-10-25 | 1982-10-25 | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
Publications (2)
Publication Number | Publication Date |
---|---|
DK487683D0 DK487683D0 (da) | 1983-10-24 |
DK487683A true DK487683A (da) | 1984-04-26 |
Family
ID=23733643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK487683A DK487683A (da) | 1982-10-25 | 1983-10-24 | Fremgangsmaade til fremstilling af 7-oxabicycloheptan-substituerede amino-prostaglandinanaloge |
Country Status (9)
Country | Link |
---|---|
US (1) | US4456615A (no) |
EP (1) | EP0107995A1 (no) |
JP (1) | JPS5993083A (no) |
AU (1) | AU2009383A (no) |
CA (1) | CA1192566A (no) |
DK (1) | DK487683A (no) |
HU (1) | HU189760B (no) |
NO (1) | NO833871L (no) |
ZA (1) | ZA837600B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537981A (en) * | 1981-11-09 | 1985-08-27 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds |
DE3280020D1 (en) * | 1981-12-23 | 1989-12-21 | Nat Res Dev | Prostaglandins |
US4837234A (en) * | 1981-12-23 | 1989-06-06 | National Research Development Corporation | Prostaglandins |
US4513103A (en) * | 1983-10-21 | 1985-04-23 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease |
GB8501035D0 (en) * | 1985-01-16 | 1985-02-20 | Senior J | Prostaglandins |
US4588741A (en) * | 1985-02-28 | 1986-05-13 | E. R. Squibb & Sons, Inc. | Platelet aggregation inhibiting and bronchoconstriction inhibiting thiabicycloheptane substituted amino prostaglandin analog derivatives, compositions, and method of use therefor |
US4607048A (en) * | 1985-05-16 | 1986-08-19 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4663336A (en) | 1985-07-01 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease |
DE3526362A1 (de) * | 1985-07-19 | 1987-01-22 | Schering Ag | Prostacycline, ihre analoga oder prostaglandine und thromboxanantagonisten zur behandlung von thrombotischen und thromboembolischen krankheitsbildern |
US4654355A (en) * | 1985-08-01 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs |
CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
US4647573A (en) * | 1985-11-22 | 1987-03-03 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted thioamide-amide prostaglandin analogs |
US4670453A (en) * | 1986-05-08 | 1987-06-02 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease |
US4816579A (en) * | 1986-06-04 | 1989-03-28 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists |
US4851553A (en) * | 1986-06-04 | 1989-07-25 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane amido-carboxylic acids |
US4958036A (en) * | 1986-06-04 | 1990-09-18 | E. R. Squibb & Sons, Inc. | Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids |
US4687865A (en) * | 1986-06-04 | 1987-08-18 | E. R. Squibb & Sons, Inc. | Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists |
US4743697A (en) * | 1986-06-04 | 1988-05-10 | E. R. Squibb & Sons, Inc. | Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists and novel intermediates procuced therein |
US4734424A (en) * | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted diamide and its congener prostaglandin analogs |
US4734426A (en) * | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs |
US4735962A (en) * | 1986-10-06 | 1988-04-05 | E. R. Squibb & Sons, Inc. | 7-thiabicycloheptane substituted diamide and its congener prostaglandin analogs |
US4734425A (en) * | 1986-10-17 | 1988-03-29 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs |
US4738978A (en) * | 1986-11-10 | 1988-04-19 | E. R. Squibb & Sons, Inc. | Bisthioamide-7-oxabicycloheptane prostaglandin analogs |
US4749715A (en) * | 1987-03-02 | 1988-06-07 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amino prostaglandin analogs |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
EP0013607B1 (en) * | 1979-01-05 | 1983-03-23 | National Research Development Corporation | Substituted bicyclo (2,2,1)heptanes and bicyclo (2,2,1) hept-2-enes and their pharmaceutical compositions |
US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
ZA829068B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
-
1982
- 1982-10-25 US US06/436,741 patent/US4456615A/en not_active Expired - Fee Related
-
1983
- 1983-10-12 AU AU20093/83A patent/AU2009383A/en not_active Abandoned
- 1983-10-12 EP EP83401988A patent/EP0107995A1/en not_active Withdrawn
- 1983-10-12 ZA ZA837600A patent/ZA837600B/xx unknown
- 1983-10-19 CA CA000439335A patent/CA1192566A/en not_active Expired
- 1983-10-24 HU HU833648A patent/HU189760B/hu unknown
- 1983-10-24 DK DK487683A patent/DK487683A/da not_active Application Discontinuation
- 1983-10-24 NO NO833871A patent/NO833871L/no unknown
- 1983-10-24 JP JP58198964A patent/JPS5993083A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS5993083A (ja) | 1984-05-29 |
NO833871L (no) | 1984-04-26 |
DK487683D0 (da) | 1983-10-24 |
HU189760B (en) | 1986-07-28 |
EP0107995A1 (en) | 1984-05-09 |
ZA837600B (en) | 1984-06-27 |
CA1192566A (en) | 1985-08-27 |
US4456615A (en) | 1984-06-26 |
AU2009383A (en) | 1984-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ATS | Application withdrawn |