DK472279A - PROCEDURE FOR MANUFACTURING A BIOLOGICAL ACTIVE MATERIAL - Google Patents

PROCEDURE FOR MANUFACTURING A BIOLOGICAL ACTIVE MATERIAL

Info

Publication number
DK472279A
DK472279A DK472279A DK472279A DK472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A
Authority
DK
Denmark
Prior art keywords
streptomyces
degrees
nitrogen
water
soluble
Prior art date
Application number
DK472279A
Other languages
Danish (da)
Other versions
DK148809C (en
DK148809B (en
Inventor
Y Kuroda
E Iguchi
M Kohsaka
H Aoki
H Imanaka
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of DK472279A publication Critical patent/DK472279A/en
Publication of DK148809B publication Critical patent/DK148809B/en
Application granted granted Critical
Publication of DK148809C publication Critical patent/DK148809C/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A biologically active substance called FR-900156 and a pharmaceutically tolerated salt of it are prepared by culturing an FR-900156-producing strain of a Streptomyces species under aerobic conditions in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts. The microorganism cultured is either Streptomyces olivaceusgriseus or Streptomyces violaceus. FR-900156 can be used therapeutically for the treatment of infectious diseases and cancer. FR-900156 probably has the following formula and name: <IMAGE> D-lactyl-L-alanyl-γ-D-glutamyl-(L)meso- diaminopimelyl-(L)-glycine FR-900156 is an amphoteric white powder that is soluble in water, sparingly soluble in methanol and insoluble in ethanol, acetone, ethyl acetate, benzene, hexane and chloroform. It melts at 143-148 degrees C with decomposition and has a specific rotation of [α]25,D = -27.1 degrees (c = 0.4 in water). Qualitative analysis shows that FR-900156 contains carbon, hydrogen, nitrogen and oxygen.
DK472279A 1978-11-14 1979-11-07 METHOD FOR PREPARING AN ANTI-BACTERIAL AND ANTI-CANCER EFFECTIVE LACTOYL TETRAPEPTID IN CULTURE DK148809C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7844346 1978-11-14
GB7844346 1978-11-14

Publications (3)

Publication Number Publication Date
DK472279A true DK472279A (en) 1980-05-15
DK148809B DK148809B (en) 1985-10-07
DK148809C DK148809C (en) 1986-03-17

Family

ID=10501019

Family Applications (1)

Application Number Title Priority Date Filing Date
DK472279A DK148809C (en) 1978-11-14 1979-11-07 METHOD FOR PREPARING AN ANTI-BACTERIAL AND ANTI-CANCER EFFECTIVE LACTOYL TETRAPEPTID IN CULTURE

Country Status (4)

Country Link
CA (1) CA1143682A (en)
DK (1) DK148809C (en)
ES (1) ES485962A1 (en)
HU (1) HU181434B (en)

Also Published As

Publication number Publication date
ES485962A1 (en) 1980-07-01
DK148809C (en) 1986-03-17
CA1143682A (en) 1983-03-29
HU181434B (en) 1983-07-28
DK148809B (en) 1985-10-07

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Legal Events

Date Code Title Description
PBP Patent lapsed