DK472279A - PROCEDURE FOR MANUFACTURING A BIOLOGICAL ACTIVE MATERIAL - Google Patents
PROCEDURE FOR MANUFACTURING A BIOLOGICAL ACTIVE MATERIALInfo
- Publication number
- DK472279A DK472279A DK472279A DK472279A DK472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A DK 472279 A DK472279 A DK 472279A
- Authority
- DK
- Denmark
- Prior art keywords
- streptomyces
- degrees
- nitrogen
- water
- soluble
- Prior art date
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A biologically active substance called FR-900156 and a pharmaceutically tolerated salt of it are prepared by culturing an FR-900156-producing strain of a Streptomyces species under aerobic conditions in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts. The microorganism cultured is either Streptomyces olivaceusgriseus or Streptomyces violaceus. FR-900156 can be used therapeutically for the treatment of infectious diseases and cancer. FR-900156 probably has the following formula and name: <IMAGE> D-lactyl-L-alanyl-γ-D-glutamyl-(L)meso- diaminopimelyl-(L)-glycine FR-900156 is an amphoteric white powder that is soluble in water, sparingly soluble in methanol and insoluble in ethanol, acetone, ethyl acetate, benzene, hexane and chloroform. It melts at 143-148 degrees C with decomposition and has a specific rotation of [α]25,D = -27.1 degrees (c = 0.4 in water). Qualitative analysis shows that FR-900156 contains carbon, hydrogen, nitrogen and oxygen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7844346 | 1978-11-14 | ||
GB7844346 | 1978-11-14 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK472279A true DK472279A (en) | 1980-05-15 |
DK148809B DK148809B (en) | 1985-10-07 |
DK148809C DK148809C (en) | 1986-03-17 |
Family
ID=10501019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK472279A DK148809C (en) | 1978-11-14 | 1979-11-07 | METHOD FOR PREPARING AN ANTI-BACTERIAL AND ANTI-CANCER EFFECTIVE LACTOYL TETRAPEPTID IN CULTURE |
Country Status (4)
Country | Link |
---|---|
CA (1) | CA1143682A (en) |
DK (1) | DK148809C (en) |
ES (1) | ES485962A1 (en) |
HU (1) | HU181434B (en) |
-
1979
- 1979-11-07 DK DK472279A patent/DK148809C/en not_active IP Right Cessation
- 1979-11-13 HU HUFU000379 patent/HU181434B/en not_active IP Right Cessation
- 1979-11-13 CA CA000339737A patent/CA1143682A/en not_active Expired
- 1979-11-14 ES ES485962A patent/ES485962A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES485962A1 (en) | 1980-07-01 |
DK148809C (en) | 1986-03-17 |
CA1143682A (en) | 1983-03-29 |
HU181434B (en) | 1983-07-28 |
DK148809B (en) | 1985-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |