DK466886A - Estere af dihydrolysergsyre, fremgangsmaade til fremstilling heraf, mellemprodukter til brug herved og praeparater indeholdende de aktive forbindelser - Google Patents

Estere af dihydrolysergsyre, fremgangsmaade til fremstilling heraf, mellemprodukter til brug herved og praeparater indeholdende de aktive forbindelser Download PDF

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Publication number
DK466886A
DK466886A DK466886A DK466886A DK466886A DK 466886 A DK466886 A DK 466886A DK 466886 A DK466886 A DK 466886A DK 466886 A DK466886 A DK 466886A DK 466886 A DK466886 A DK 466886A
Authority
DK
Denmark
Prior art keywords
dihydrolyric
esthers
intermediates
procedures
preparing
Prior art date
Application number
DK466886A
Other languages
Danish (da)
English (en)
Other versions
DK466886D0 (da
Inventor
William L Garbrecht
Gifford P Marzoni
Carol J Parli
Kathleen R Whitten
Marlene L Cohen
Ray W Fuller
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/782,338 external-priority patent/US4713384A/en
Priority claimed from US06/782,342 external-priority patent/US4772709A/en
Priority claimed from US06/782,337 external-priority patent/US4683236A/en
Priority claimed from US06/782,340 external-priority patent/US4714704A/en
Priority claimed from US06/782,341 external-priority patent/US4713385A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK466886D0 publication Critical patent/DK466886D0/da
Publication of DK466886A publication Critical patent/DK466886A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK466886A 1985-10-01 1986-09-30 Estere af dihydrolysergsyre, fremgangsmaade til fremstilling heraf, mellemprodukter til brug herved og praeparater indeholdende de aktive forbindelser DK466886A (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US06/782,338 US4713384A (en) 1985-10-01 1985-10-01 Selective method for blocking 5HT2 receptors
US06/782,342 US4772709A (en) 1985-10-01 1985-10-01 Process of making ketoalkanol esters of dihydrolysergic acid
US06/782,337 US4683236A (en) 1985-10-01 1985-10-01 Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
US06/782,340 US4714704A (en) 1985-10-01 1985-10-01 Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US06/782,341 US4713385A (en) 1985-10-01 1985-10-01 Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists

Publications (2)

Publication Number Publication Date
DK466886D0 DK466886D0 (da) 1986-09-30
DK466886A true DK466886A (da) 1987-04-02

Family

ID=27542204

Family Applications (1)

Application Number Title Priority Date Filing Date
DK466886A DK466886A (da) 1985-10-01 1986-09-30 Estere af dihydrolysergsyre, fremgangsmaade til fremstilling heraf, mellemprodukter til brug herved og praeparater indeholdende de aktive forbindelser

Country Status (17)

Country Link
EP (1) EP0219257B1 (ja)
JP (1) JPH0723376B2 (ja)
KR (1) KR880001009B1 (ja)
AR (1) AR244687A1 (ja)
AU (1) AU594373B2 (ja)
CY (1) CY1784A (ja)
DE (1) DE3689702T2 (ja)
DK (1) DK466886A (ja)
ES (1) ES2002392A6 (ja)
GR (1) GR862466B (ja)
HK (1) HK51894A (ja)
HU (1) HU206711B (ja)
IE (1) IE61976B1 (ja)
IL (1) IL80193A0 (ja)
MY (1) MY102598A (ja)
NZ (1) NZ217724A (ja)
PT (1) PT83450B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734501A (en) * 1985-10-01 1988-03-29 Eli Lilly And Company N-alkylation of dihydrolysergic acid
US4782063A (en) * 1987-05-11 1988-11-01 Eli Lilly And Company Ergoline esters useful as serotonin antagonists
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
WO1996032944A1 (en) * 1995-04-18 1996-10-24 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
EP2846763B1 (de) * 2012-05-08 2017-02-08 Merck Patent GmbH Verwendung von cyclohexanolethern mit antimikrobiellen eigenschaften

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3580916A (en) * 1969-02-20 1971-05-25 Lilly Co Eli Hydroxyesters of hexa- and octahydroindoloquinolines
CH549571A (de) * 1970-09-16 1974-05-31 Lilly Co Eli Verfahren zur herstellung von estern der lysergsaeure bzw. dihydrolysergsaeure und deren verwendung.
US4563461A (en) * 1983-03-10 1986-01-07 Eli Lilly And Company Selective method for blocking 5HT2 receptors
US4734501A (en) * 1985-10-01 1988-03-29 Eli Lilly And Company N-alkylation of dihydrolysergic acid
US4713384A (en) * 1985-10-01 1987-12-15 Eli Lilly And Company Selective method for blocking 5HT2 receptors

Also Published As

Publication number Publication date
DE3689702T2 (de) 1994-07-28
MY102598A (en) 1992-08-17
IE862588L (en) 1987-04-01
PT83450A (en) 1986-10-01
EP0219257A2 (en) 1987-04-22
HUT41780A (en) 1987-05-28
CY1784A (en) 1995-10-20
GR862466B (en) 1987-02-02
HU206711B (en) 1992-12-28
KR870004028A (ko) 1987-05-07
AU594373B2 (en) 1990-03-08
JPS6284084A (ja) 1987-04-17
ES2002392A6 (es) 1988-08-01
IE61976B1 (en) 1994-12-14
IL80193A0 (en) 1986-12-31
DE3689702D1 (de) 1994-04-14
JPH0723376B2 (ja) 1995-03-15
EP0219257B1 (en) 1994-03-09
HK51894A (en) 1994-05-27
AR244687A1 (es) 1993-11-30
EP0219257A3 (en) 1988-12-28
DK466886D0 (da) 1986-09-30
PT83450B (pt) 1989-05-12
KR880001009B1 (ko) 1988-06-13
AU6321086A (en) 1987-04-02
NZ217724A (en) 1989-02-24

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