DK445884A - Fremgangsmaade til fremstilling af 1,4-dialkyl-3-methyl-4-(3-substitueret phenyl)-piperidiner og mellemprodukt til brug ved fremgangsmaaden - Google Patents
Fremgangsmaade til fremstilling af 1,4-dialkyl-3-methyl-4-(3-substitueret phenyl)-piperidiner og mellemprodukt til brug ved fremgangsmaaden Download PDFInfo
- Publication number
- DK445884A DK445884A DK445884A DK445884A DK445884A DK 445884 A DK445884 A DK 445884A DK 445884 A DK445884 A DK 445884A DK 445884 A DK445884 A DK 445884A DK 445884 A DK445884 A DK 445884A
- Authority
- DK
- Denmark
- Prior art keywords
- piperidines
- dialkyl
- intermediates
- methyl
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/534,468 US4581456A (en) | 1983-09-21 | 1983-09-21 | Processes for preparing picenadol precursors and novel intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK445884D0 DK445884D0 (da) | 1984-09-19 |
| DK445884A true DK445884A (da) | 1985-03-22 |
Family
ID=24130174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK445884A DK445884A (da) | 1983-09-21 | 1984-09-19 | Fremgangsmaade til fremstilling af 1,4-dialkyl-3-methyl-4-(3-substitueret phenyl)-piperidiner og mellemprodukt til brug ved fremgangsmaaden |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4581456A (ko) |
| EP (2) | EP0136863B1 (ko) |
| JP (1) | JPS6094961A (ko) |
| KR (1) | KR870000270B1 (ko) |
| CA (1) | CA1223258A (ko) |
| DE (1) | DE3471301D1 (ko) |
| DK (1) | DK445884A (ko) |
| GB (1) | GB2146641B (ko) |
| GR (1) | GR80426B (ko) |
| HU (1) | HUT35247A (ko) |
| IL (1) | IL72998A (ko) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5319087A (en) * | 1987-04-16 | 1994-06-07 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4992450A (en) * | 1987-04-16 | 1991-02-12 | Eli Lilly And Company | Piperidine opioid antagonists |
| US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
| US5136040A (en) * | 1991-02-26 | 1992-08-04 | Eli Lilly And Company | Preparation of substituted tetrahydropyridines |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
| US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
| WO2000012476A1 (en) * | 1998-08-28 | 2000-03-09 | Reilly Industries, Inc. | Processes for preparing 2-piperidineethanol compounds |
| GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| US20050148630A1 (en) * | 2003-12-02 | 2005-07-07 | Carpenter Randall L. | Methods of preventing and treating non-opioid induced gastrointestinal dysfunction |
| US8946262B2 (en) * | 2003-12-04 | 2015-02-03 | Adolor Corporation | Methods of preventing and treating gastrointestinal dysfunction |
| US20050240177A1 (en) * | 2004-04-26 | 2005-10-27 | Packaging Service Corporation Of Kentucky | Electrosurgical forceps |
| US7700626B2 (en) * | 2004-06-04 | 2010-04-20 | Adolor Corporation | Compositions containing opioid antagonists |
| US20060211733A1 (en) * | 2005-03-04 | 2006-09-21 | Adolor Corporation | Methods of preventing and treating opioid bowel dysfunction |
| US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662390B2 (en) * | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US7914776B2 (en) * | 2005-10-07 | 2011-03-29 | Adolor Corporation | Solid dispersions of opioid antagonists |
| US20070092576A1 (en) * | 2005-10-20 | 2007-04-26 | Adolor Corporation | Compositions containing opioid antagonists |
| EP2278966B1 (en) | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2892842A (en) * | 1959-06-30 | Their preparation | ||
| US2845431A (en) * | 1952-04-22 | 1958-07-29 | Hoffmann La Roche | Alkyl-piperidiones and process for the manufacture thereof |
| US3177258A (en) * | 1960-02-24 | 1965-04-06 | Engelhard Ind Inc | Hydrogenation process using rutheniumcontaining catalysts |
| US3946086A (en) * | 1970-10-28 | 1976-03-23 | Felix Borisovich Gershanov | Method of producing 2,6-dialkyl- and 2,6-diaralkyl-substituted derivatives of p-cresol |
| AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
| US4115400A (en) * | 1976-05-27 | 1978-09-19 | Eli Lilly And Company | 1-Azoniabicyclo[3.1.0]hexanes |
| US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
| US4228288A (en) * | 1978-11-29 | 1980-10-14 | Eli Lilly And Company | Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates |
-
1983
- 1983-09-21 US US06/534,468 patent/US4581456A/en not_active Expired - Fee Related
-
1984
- 1984-09-17 CA CA000463357A patent/CA1223258A/en not_active Expired
- 1984-09-18 EP EP84306362A patent/EP0136863B1/en not_active Expired
- 1984-09-18 EP EP87109266A patent/EP0247639A3/en not_active Withdrawn
- 1984-09-18 GB GB08423601A patent/GB2146641B/en not_active Expired
- 1984-09-18 DE DE8484306362T patent/DE3471301D1/de not_active Expired
- 1984-09-19 IL IL72998A patent/IL72998A/xx unknown
- 1984-09-19 DK DK445884A patent/DK445884A/da not_active Application Discontinuation
- 1984-09-20 HU HU833536A patent/HUT35247A/hu unknown
- 1984-09-20 GR GR80426A patent/GR80426B/el unknown
- 1984-09-21 KR KR1019840005800A patent/KR870000270B1/ko active IP Right Grant
- 1984-09-21 JP JP59199328A patent/JPS6094961A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR850002469A (ko) | 1985-05-13 |
| GB2146641A (en) | 1985-04-24 |
| CA1223258A (en) | 1987-06-23 |
| GB8423601D0 (en) | 1984-10-24 |
| JPS6094961A (ja) | 1985-05-28 |
| GB2146641B (en) | 1987-05-28 |
| EP0247639A2 (en) | 1987-12-02 |
| HUT35247A (en) | 1985-06-28 |
| KR870000270B1 (ko) | 1987-02-23 |
| DK445884D0 (da) | 1984-09-19 |
| IL72998A (en) | 1988-03-31 |
| US4581456A (en) | 1986-04-08 |
| GR80426B (en) | 1985-01-22 |
| EP0247639A3 (en) | 1988-07-06 |
| EP0136863A2 (en) | 1985-04-10 |
| DE3471301D1 (en) | 1988-06-23 |
| EP0136863A3 (en) | 1985-07-31 |
| EP0136863B1 (en) | 1988-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |