DK437886A - Makrocycliske antibiotika samt deres fremstilling og anvendelse - Google Patents

Makrocycliske antibiotika samt deres fremstilling og anvendelse Download PDF

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Publication number
DK437886A
DK437886A DK437886A DK437886A DK437886A DK 437886 A DK437886 A DK 437886A DK 437886 A DK437886 A DK 437886A DK 437886 A DK437886 A DK 437886A DK 437886 A DK437886 A DK 437886A
Authority
DK
Denmark
Prior art keywords
preparation
macrocyclic antibiotics
hydroxy
compounds
macrocyclic
Prior art date
Application number
DK437886A
Other languages
English (en)
Other versions
DK162390C (da
DK162390B (da
DK437886D0 (da
Inventor
Hans Reichenbach
Gerhard Hoefle
Hermann Augustiniak
Norbert Bedorf
Klaus Gerth
Herbert Irschik
Original Assignee
Biotechnolog Forschung Gmbh
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh, Ciba Geigy Ag filed Critical Biotechnolog Forschung Gmbh
Publication of DK437886D0 publication Critical patent/DK437886D0/da
Publication of DK437886A publication Critical patent/DK437886A/da
Publication of DK162390B publication Critical patent/DK162390B/da
Application granted granted Critical
Publication of DK162390C publication Critical patent/DK162390C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK437886A 1985-09-13 1986-09-12 Makrocycliske forbindelser, fermenteringsfremgangsmaade til fremstilling heraf, mikroorganisme til brug ved fremgangsmaaden, farmaceutiske praeparater indeholdende forbindelserne, samt anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater og plantebeskyttelsesmidler DK162390C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH398685 1985-09-13
CH398685 1985-09-13

Publications (4)

Publication Number Publication Date
DK437886D0 DK437886D0 (da) 1986-09-12
DK437886A true DK437886A (da) 1987-03-14
DK162390B DK162390B (da) 1991-10-21
DK162390C DK162390C (da) 1992-03-09

Family

ID=4267667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK437886A DK162390C (da) 1985-09-13 1986-09-12 Makrocycliske forbindelser, fermenteringsfremgangsmaade til fremstilling heraf, mikroorganisme til brug ved fremgangsmaaden, farmaceutiske praeparater indeholdende forbindelserne, samt anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater og plantebeskyttelsesmidler

Country Status (9)

Country Link
US (2) US4987072A (da)
EP (1) EP0216731B1 (da)
JP (1) JPS62181281A (da)
AT (1) ATE51003T1 (da)
DE (1) DE3669515D1 (da)
DK (1) DK162390C (da)
ES (1) ES2001783A6 (da)
GR (1) GR862324B (da)
PT (1) PT83356B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0358607A3 (de) * 1988-09-09 1990-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF) Mikrobizide makrozyklische Laktonderivate
EP0358606A3 (de) * 1988-09-09 1990-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF) Mikrobiologisches Verfahren zur Herstellung agrarchemisch verwendbarer mikrobizider makrozyklischer Lactonderivate
EP0358608A3 (de) * 1988-09-09 1990-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF) Mikrobizide makrozyklische Laktonderivate
DE3930950A1 (de) * 1989-09-15 1991-03-28 Biotechnolog Forschung Gmbh Synthetische sorangicin-varianten und herstellungsverfahren
US5393897A (en) * 1993-07-02 1995-02-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of spongistatins 5,7,8 and 9
US5380838A (en) * 1993-10-08 1995-01-10 Merck & Co. Inc. Stable solvates of avermectin compounds
US5478861A (en) * 1994-02-18 1995-12-26 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5684036A (en) * 1994-02-18 1997-11-04 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
CA2695720C (en) * 2002-09-23 2013-04-02 Bristol-Myers Squibb Company Method of producing epothilone b by culturing sorangium cellulosum in a medium comprising propionic acid
JP2010110216A (ja) * 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
EP3498714B1 (en) 2017-12-14 2020-07-22 Helmholtz-Zentrum für Infektionsforschung GmbH Novel sorangicin antibiotic
CN119912420B (zh) * 2024-12-19 2025-07-18 首都医科大学附属北京世纪坛医院 一种山姜素衍生物及其制备方法、药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651216A (en) * 1970-05-11 1972-03-21 Warner Lambert Co Antibiotic substances produced by polyangium cellulosum var. fulvum
DE3700331A1 (de) * 1986-12-24 1988-07-07 Hoechst Ag Verfahren zur herstellung der desmalonylverbindung von makrolid-lactonen

Also Published As

Publication number Publication date
PT83356B (pt) 1989-05-12
EP0216731A1 (de) 1987-04-01
PT83356A (en) 1986-10-01
JPS62181281A (ja) 1987-08-08
GR862324B (en) 1987-01-12
DK162390C (da) 1992-03-09
ES2001783A6 (es) 1988-06-16
ATE51003T1 (de) 1990-03-15
DK162390B (da) 1991-10-21
DK437886D0 (da) 1986-09-12
DE3669515D1 (de) 1990-04-19
US5096922A (en) 1992-03-17
US4987072A (en) 1991-01-22
EP0216731B1 (de) 1990-03-14

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