DK42589A - Anvendelse af arylamida(og arylthioamido)-azabicycloalkaner - Google Patents
Anvendelse af arylamida(og arylthioamido)-azabicycloalkanerInfo
- Publication number
- DK42589A DK42589A DK042589A DK42589A DK42589A DK 42589 A DK42589 A DK 42589A DK 042589 A DK042589 A DK 042589A DK 42589 A DK42589 A DK 42589A DK 42589 A DK42589 A DK 42589A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- hydrogen atom
- loweralkyl
- phenyl
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/44—Moulds or cores; Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/150,981 US4863919A (en) | 1988-02-01 | 1988-02-01 | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
Publications (2)
Publication Number | Publication Date |
---|---|
DK42589D0 DK42589D0 (da) | 1989-01-31 |
DK42589A true DK42589A (da) | 1989-08-02 |
Family
ID=22536826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK042589A DK42589A (da) | 1988-02-01 | 1989-01-31 | Anvendelse af arylamida(og arylthioamido)-azabicycloalkaner |
Country Status (16)
Country | Link |
---|---|
US (1) | US4863919A (fr) |
EP (1) | EP0327335B1 (fr) |
JP (1) | JPH01226818A (fr) |
KR (1) | KR890012649A (fr) |
AT (1) | ATE81457T1 (fr) |
AU (1) | AU629197B2 (fr) |
CA (1) | CA1320448C (fr) |
DE (1) | DE68903178T2 (fr) |
DK (1) | DK42589A (fr) |
ES (1) | ES2045402T3 (fr) |
GR (1) | GR3006764T3 (fr) |
IL (1) | IL88434A (fr) |
NZ (1) | NZ227794A (fr) |
PH (1) | PH25906A (fr) |
PT (1) | PT89575B (fr) |
ZA (1) | ZA889109B (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU654013B2 (en) * | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
US5723103A (en) * | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
US6492386B2 (en) * | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
AU2001282874A1 (en) * | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
US6486172B2 (en) * | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
AU2001282910A1 (en) * | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands |
WO2002015662A2 (fr) * | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Fractions heteroaryle substituees par quinuclidine destinees au traitement de maladies |
US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
JP2005510482A (ja) * | 2001-10-16 | 2005-04-21 | アストラゼネカ・アクチエボラーグ | 線維筋痛症候群の治療方法 |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
JP2005511574A (ja) * | 2001-10-26 | 2005-04-28 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | Nachrアゴニストとしてのn−アザビシクロ−置換ヘテロ二環式カルボキサミド |
US6919359B2 (en) * | 2001-11-08 | 2005-07-19 | Pfizer Inc | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
DE10156719A1 (de) | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US6852716B2 (en) * | 2002-02-15 | 2005-02-08 | Pfizer Inc | Substituted-aryl compounds for treatment of disease |
WO2003070731A2 (fr) * | 2002-02-19 | 2003-08-28 | Pharmacia & Upjohn Company | Composes azabicycliques servant a traiter des maladies |
EP1478646A1 (fr) * | 2002-02-20 | 2004-11-24 | PHARMACIA & UPJOHN COMPANY | Composes azabicycliques presentant une activite de recepteurs d'alfa 7 nicotinique acetylcholine |
JP2005537297A (ja) | 2002-08-01 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | アルファ−7nachr活性を有する1h−ピラゾールおよび1h−ピロール−アザビシクロ化合物 |
JP2006506395A (ja) * | 2002-11-01 | 2006-02-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | CNS疾患の治療のための、α7ニコチンアゴニスト活性及び5HT3アンタゴニスト活性を有する化合物 |
MXPA05011537A (es) | 2003-04-30 | 2006-01-23 | Inst For Pharm Discovery Inc | Acidos aminocaboxilicos sustituidos. |
EP1814869A2 (fr) | 2004-11-18 | 2007-08-08 | The Institutes for Pharmaceutical Discovery, LLC | Amino acides substitues comme inhibiteurs de la proteine tyrosine phosphatase |
US20080242688A1 (en) * | 2007-03-19 | 2008-10-02 | Astrazeneca Ab | Method 741 |
EP2344636B1 (fr) | 2008-10-09 | 2017-12-06 | Howard Hughes Medical Institute | Canaux ioniques chimériques inédits activés par la fixation d'un ligand et leurs procédés d'utilisation |
MY173229A (en) | 2008-11-19 | 2020-01-07 | Forum Pharmaceuticals Inc | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
SI3029039T1 (en) | 2010-05-17 | 2018-04-30 | Forum Pharmaceuticals Inc. | Pharmaceutical formulations containing crystalline forms of (R) -7-chloro-N- (quinuclidin-3-yl) benzo (b) thiophene-2-carboxamide hydrochloride monohydrate |
TWI589576B (zh) | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜-雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
EP3233087B1 (fr) * | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Composés amide de quinuclidine à substituants géminal, en tant qu'agonistes des récepteurs nicotiniques de l'acétylcholine 7 |
MX2017016231A (es) | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI763021A (fr) * | 1975-11-03 | 1977-05-04 | Thomae Gmbh Dr K | |
GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
EP0067565A1 (fr) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Benzamides bicycliques, leur procédé de préparation et leur application |
FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
FR2529548A1 (fr) * | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
DE3446484A1 (de) * | 1984-12-20 | 1986-07-03 | Sandoz-Patent-GmbH, 7850 Lörrach | Therapeutische verwendung von benzoesaeurepiperidylestern oder -amiden |
US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
US4870181A (en) * | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
DE201165T1 (de) * | 1985-03-14 | 1989-04-20 | Beecham Group P.L.C., Brentford | Arzneimittel zur behandlung von emesis, anxietas und "irritable bowel syndrome". |
GB8511988D0 (en) * | 1985-05-11 | 1985-06-19 | Beecham Group Plc | Compounds |
GB8515845D0 (en) * | 1985-06-22 | 1985-07-24 | Beecham Group Plc | Treatment |
US4717563A (en) * | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
-
1988
- 1988-02-01 US US07/150,981 patent/US4863919A/en not_active Expired - Fee Related
- 1988-11-21 IL IL88434A patent/IL88434A/xx not_active IP Right Cessation
- 1988-12-05 ZA ZA889109A patent/ZA889109B/xx unknown
-
1989
- 1989-01-23 JP JP1013894A patent/JPH01226818A/ja active Pending
- 1989-01-26 CA CA000589194A patent/CA1320448C/fr not_active Expired - Fee Related
- 1989-01-30 NZ NZ227794A patent/NZ227794A/en unknown
- 1989-01-31 PT PT89575A patent/PT89575B/pt active IP Right Grant
- 1989-01-31 PH PH38133A patent/PH25906A/en unknown
- 1989-01-31 DK DK042589A patent/DK42589A/da not_active Application Discontinuation
- 1989-01-31 KR KR1019890001079A patent/KR890012649A/ko not_active Application Discontinuation
- 1989-02-01 DE DE8989300961T patent/DE68903178T2/de not_active Expired - Fee Related
- 1989-02-01 EP EP89300961A patent/EP0327335B1/fr not_active Expired - Lifetime
- 1989-02-01 AT AT89300961T patent/ATE81457T1/de not_active IP Right Cessation
- 1989-02-01 ES ES89300961T patent/ES2045402T3/es not_active Expired - Lifetime
- 1989-02-01 AU AU29506/89A patent/AU629197B2/en not_active Ceased
-
1993
- 1993-01-11 GR GR930400020T patent/GR3006764T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE68903178T2 (de) | 1993-03-18 |
JPH01226818A (ja) | 1989-09-11 |
GR3006764T3 (fr) | 1993-06-30 |
IL88434A (en) | 1992-09-06 |
IL88434A0 (en) | 1989-06-30 |
PT89575B (pt) | 1994-01-31 |
US4863919A (en) | 1989-09-05 |
EP0327335B1 (fr) | 1992-10-14 |
ZA889109B (en) | 1989-08-30 |
PH25906A (en) | 1991-12-19 |
DE68903178D1 (de) | 1992-11-19 |
NZ227794A (en) | 1991-12-23 |
KR890012649A (ko) | 1989-09-18 |
PT89575A (pt) | 1989-10-04 |
EP0327335A1 (fr) | 1989-08-09 |
ATE81457T1 (de) | 1992-10-15 |
CA1320448C (fr) | 1993-07-20 |
DK42589D0 (da) | 1989-01-31 |
AU629197B2 (en) | 1992-10-01 |
ES2045402T3 (es) | 1994-01-16 |
AU2950689A (en) | 1989-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |