DK41584A - OPTICALLY ACTIVE BICYCLIC IMINO-ALFA CARBOXYL ACID ESTERS, PROCEDURES FOR SEPARATING RACEMIC MIXTURES THEREOF, AND USING THE OBTAINED COMPOUNDS FOR SYNTHESIS OF CARBOXYLYPTY - Google Patents

OPTICALLY ACTIVE BICYCLIC IMINO-ALFA CARBOXYL ACID ESTERS, PROCEDURES FOR SEPARATING RACEMIC MIXTURES THEREOF, AND USING THE OBTAINED COMPOUNDS FOR SYNTHESIS OF CARBOXYLYPTY Download PDF

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Publication number
DK41584A
DK41584A DK41584A DK41584A DK41584A DK 41584 A DK41584 A DK 41584A DK 41584 A DK41584 A DK 41584A DK 41584 A DK41584 A DK 41584A DK 41584 A DK41584 A DK 41584A
Authority
DK
Denmark
Prior art keywords
carboxylypty
alfa
procedures
synthesis
acid esters
Prior art date
Application number
DK41584A
Other languages
Danish (da)
Other versions
DK174386B1 (en
DK41584D0 (en
Inventor
Rolf Geiger
Volker Teetz
Dietrich Langner
Hansjoerg Urbach
Rainer Henning
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833303139 external-priority patent/DE3303139A1/en
Priority claimed from DE19833303112 external-priority patent/DE3303112A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK41584D0 publication Critical patent/DK41584D0/en
Publication of DK41584A publication Critical patent/DK41584A/en
Application granted granted Critical
Publication of DK174386B1 publication Critical patent/DK174386B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK198400415A 1983-01-31 1984-01-30 Bicyclic imino-alpha-carboxylic acid esters, process for their preparation by separating racemic mixtures thereof, optionally in the form of their hydrochloride or tosylate salt, and diastereomeric salt in the form of a protected N-acylated, ...... DK174386B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19833303139 DE3303139A1 (en) 1983-01-31 1983-01-31 Process for the preparation of carboxyalkyldipeptides
DE3303139 1983-01-31
DE19833303112 DE3303112A1 (en) 1983-01-31 1983-01-31 METHOD FOR RACEMATE SEPARATION OF OPTICALLY ACTIVE BICYCLIC IMINO (ALPHA) CARBONIC ACIDS
DE3303112 1983-01-31

Publications (3)

Publication Number Publication Date
DK41584D0 DK41584D0 (en) 1984-01-30
DK41584A true DK41584A (en) 1984-08-01
DK174386B1 DK174386B1 (en) 2003-01-27

Family

ID=25807929

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198400415A DK174386B1 (en) 1983-01-31 1984-01-30 Bicyclic imino-alpha-carboxylic acid esters, process for their preparation by separating racemic mixtures thereof, optionally in the form of their hydrochloride or tosylate salt, and diastereomeric salt in the form of a protected N-acylated, ......

Country Status (17)

Country Link
EP (1) EP0115345B1 (en)
JP (1) JPH0788358B2 (en)
KR (1) KR910001438B1 (en)
AU (1) AU566589B2 (en)
CA (2) CA1283249C (en)
DE (1) DE3468415D1 (en)
DK (1) DK174386B1 (en)
ES (2) ES529272A0 (en)
FI (1) FI88153C (en)
GR (1) GR82650B (en)
HU (1) HU191120B (en)
IE (1) IE56654B1 (en)
IL (1) IL70830A (en)
MA (1) MA20020A1 (en)
NO (1) NO166641C (en)
NZ (1) NZ206980A (en)
PT (1) PT78036B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
DE3345355A1 (en) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt METHOD FOR RACEMATE CLEAVING BICYCLIC IMINO (ALPHA) CARBONIC ACID ESTERS
AU581919B2 (en) * 1984-07-30 1989-03-09 Schering Corporation Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
US6407262B1 (en) 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
WO2006059347A2 (en) * 2004-12-01 2006-06-08 Morepen Laboratories Limited Improved process for preparation of ramipril
US8558023B2 (en) 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (en) * 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids

Also Published As

Publication number Publication date
IL70830A0 (en) 1984-04-30
PT78036B (en) 1986-05-30
GR82650B (en) 1985-02-07
DK174386B1 (en) 2003-01-27
EP0115345A1 (en) 1984-08-08
IE840210L (en) 1984-07-31
CA1317067C (en) 1993-04-27
FI840350A (en) 1984-08-01
ES531284A0 (en) 1984-12-01
ES8501759A1 (en) 1984-12-01
EP0115345B1 (en) 1988-01-07
IE56654B1 (en) 1991-10-23
ES8500228A1 (en) 1984-10-01
FI88153B (en) 1992-12-31
KR910001438B1 (en) 1991-03-07
PT78036A (en) 1984-02-01
JPH0517439A (en) 1993-01-26
IL70830A (en) 1988-02-29
FI840350A0 (en) 1984-01-27
NO840350L (en) 1984-08-01
MA20020A1 (en) 1984-10-01
CA1283249C (en) 1991-04-16
NO166641B (en) 1991-05-13
DE3468415D1 (en) 1988-02-11
HUT34159A (en) 1985-02-28
HU191120B (en) 1987-01-28
AU2393384A (en) 1984-08-02
FI88153C (en) 1993-04-13
AU566589B2 (en) 1987-10-22
NZ206980A (en) 1988-05-30
ES529272A0 (en) 1984-10-01
NO166641C (en) 1991-08-21
DK41584D0 (en) 1984-01-30
JPH0788358B2 (en) 1995-09-27

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