DK3962923T3 - Fremgangsmåde til separation af antistoffer eller antistoffragmenter uden en fc-region som kan binde til protein a - Google Patents

Fremgangsmåde til separation af antistoffer eller antistoffragmenter uden en fc-region som kan binde til protein a Download PDF

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Publication number
DK3962923T3
DK3962923T3 DK20723090.5T DK20723090T DK3962923T3 DK 3962923 T3 DK3962923 T3 DK 3962923T3 DK 20723090 T DK20723090 T DK 20723090T DK 3962923 T3 DK3962923 T3 DK 3962923T3
Authority
DK
Denmark
Prior art keywords
antibodies
separation
procedure
region
antibody fragments
Prior art date
Application number
DK20723090.5T
Other languages
English (en)
Other versions
DK3962923T5 (da
Inventor
Gustav Rodrigo
Mats Ander
Tomas Björkman
Ronnie Palmgren
Charlotte Brink
Original Assignee
Cytiva Bioprocess R & D Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytiva Bioprocess R & D Ab filed Critical Cytiva Bioprocess R & D Ab
Application granted granted Critical
Publication of DK3962923T3 publication Critical patent/DK3962923T3/da
Publication of DK3962923T5 publication Critical patent/DK3962923T5/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK20723090.5T 2019-04-29 2020-04-29 Fremgangsmåde til separation af antistoffer eller antistoffragmenter uden en fc-region som kan binde til protein a DK3962923T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962839840P 2019-04-29 2019-04-29
PCT/EP2020/061826 WO2020221781A1 (en) 2019-04-29 2020-04-29 Method for separation of antibodies or antibody fragments being devoid of an fc region capable of binding to protein a

Publications (2)

Publication Number Publication Date
DK3962923T3 true DK3962923T3 (da) 2023-06-06
DK3962923T5 DK3962923T5 (da) 2024-08-05

Family

ID=70480273

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20723090.5T DK3962923T5 (da) 2019-04-29 2020-04-29 Fremgangsmåde til separation af antistoffer eller antistoffragmenter uden en fc-region som kan binde til protein a

Country Status (8)

Country Link
US (1) US20220315647A1 (da)
EP (1) EP3962923B1 (da)
JP (1) JP2022533017A (da)
KR (1) KR20220002325A (da)
CN (1) CN113748128B (da)
DK (1) DK3962923T5 (da)
ES (1) ES2945795T3 (da)
WO (1) WO2020221781A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202018588D0 (en) * 2020-11-26 2021-01-13 Cytiva Bioprocess R & D Ab Separation matrix
GB202109246D0 (en) * 2021-06-28 2021-08-11 Cytiva Bioprocess R & D Ab A method of separating bispecific antibodies

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9601368D0 (sv) 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
SE0200943D0 (sv) 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
SE0402322D0 (sv) 2004-09-22 2004-09-22 Amersham Biosciences Ab Method of preparing a chromatography matrix
EP2412809B1 (en) * 2009-03-24 2017-08-09 Kaneka Corporation Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand
GB201119192D0 (en) 2011-11-07 2011-12-21 Ucl Business Plc Chromatography medium
WO2015052460A1 (en) 2013-10-09 2015-04-16 Ucl Business Plc Chromatography medium
ES2914278T3 (es) * 2016-05-11 2022-06-08 Cytiva Bioprocess R & D Ab Polipéptidos de unión a inmunoglobulina mutados
EP3455242B1 (en) * 2016-05-11 2021-06-23 Cytiva BioProcess R&D AB Separation method
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
GB201708277D0 (en) * 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein

Also Published As

Publication number Publication date
JP2022533017A (ja) 2022-07-21
WO2020221781A1 (en) 2020-11-05
CN113748128B (zh) 2024-05-14
ES2945795T3 (es) 2023-07-07
EP3962923A1 (en) 2022-03-09
DK3962923T5 (da) 2024-08-05
US20220315647A1 (en) 2022-10-06
CN113748128A (zh) 2021-12-03
KR20220002325A (ko) 2022-01-06
EP3962923B1 (en) 2023-04-19

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