DK395888A - 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne - Google Patents

8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Info

Publication number
DK395888A
DK395888A DK395888A DK395888A DK395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A DK 395888 A DK395888 A DK 395888A
Authority
DK
Denmark
Prior art keywords
atoms
group
groups
alkyl
substituted
Prior art date
Application number
DK395888A
Other languages
Danish (da)
English (en)
Other versions
DK395888D0 (da
Inventor
Derk Hamminga
Ineke Van Wijngaarden
Johannes Wilhelmus Cath Jansen
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of DK395888D0 publication Critical patent/DK395888D0/da
Publication of DK395888A publication Critical patent/DK395888A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK395888A 1987-07-20 1988-07-15 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne DK395888A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8701709 1987-07-20

Publications (2)

Publication Number Publication Date
DK395888D0 DK395888D0 (da) 1988-07-15
DK395888A true DK395888A (da) 1989-01-21

Family

ID=19850345

Family Applications (1)

Application Number Title Priority Date Filing Date
DK395888A DK395888A (da) 1987-07-20 1988-07-15 8,9-anelleret-1,2,3,4-tetrahydro-beta-carbolinderivater og deres salte og prolaegemidler, og farmaceutiske kompositioner indeholdende forbindelserne

Country Status (11)

Country Link
US (1) US5100884A (fr)
EP (1) EP0300541B1 (fr)
JP (1) JPS6434984A (fr)
AT (1) ATE136032T1 (fr)
AU (1) AU613059B2 (fr)
CA (1) CA1338189C (fr)
DE (1) DE3855147D1 (fr)
DK (1) DK395888A (fr)
IL (1) IL87150A (fr)
NZ (1) NZ225421A (fr)
ZA (1) ZA885146B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347980A1 (fr) * 1988-06-20 1989-12-27 Duphar International Research B.V B-carbolines, 8,9-cyclisées et B-carbolines, 3,4-dihydro, 8,9 cyclisées
EP0357122A3 (fr) * 1988-08-29 1991-10-23 Duphar International Research B.V L'application des bêta-carbolines, benzofurane et benzothiophène analogues pour obtenir un médicament à activité cytostatique
EP0377238A1 (fr) * 1988-12-22 1990-07-11 Duphar International Research B.V Indolo(3,2-c)-lactames annelés
EP0380155A1 (fr) * 1989-01-19 1990-08-01 Duphar International Research B.V Dérivés de 1,2,3,4-tétrahydro-bêta-carboline, 8,9-annelés
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
CA2195697A1 (fr) * 1996-02-02 1997-08-03 Masahumi Kitano Derives substitues de la guanidine, procede pour leur obtention et leurs utilisations pharmaceutiques
ES2228549T3 (es) * 1999-06-15 2005-04-16 Bristol-Myers Squibb Pharma Company Gamma-carbolinas condensadas con heterociclo sustituido.
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
PL352862A1 (en) * 1999-06-30 2003-09-08 Mochida Pharmaceutical Co, Ltd. Tricyclic compounds having spiro union
US6858599B2 (en) 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US6849619B2 (en) * 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
WO2002059129A2 (fr) 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Pyridoindoles substitues en tant qu'agonistes et antagonistes de serotonine
US7855295B2 (en) 2004-01-23 2010-12-21 Novartis Vaccines And Diagnostics, Inc. Tetrahydrocarboline compounds as anticancer agents
CN1980672B (zh) 2004-03-15 2011-05-04 Ptc医疗公司 用于抑制血管生成的咔啉衍生物
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8563567B2 (en) 2009-12-30 2013-10-22 Arqule, Inc. Substituted heterocyclic compounds
DE102019128072B4 (de) 2019-10-17 2021-11-18 Infineon Technologies Ag Transistorbauelement mit einem variierenden flächenbezogenen spezifischen gaterunnerwiderstand

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299078A (en) * 1962-10-01 1967-01-17 Smith Kline French Lab Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
DK72180A (da) * 1979-04-10 1980-10-11 Ciba Geigy Ag Fremgangsmaade til fremstilling af diazatricycler samt salte deraf
EP0190472B1 (fr) * 1984-12-21 1989-07-12 Duphar International Research B.V Médicaments à activité antipsychotique
DK686688A (da) * 1987-12-14 1989-06-15 Duphar Int Res 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
EP0357122A3 (fr) * 1988-08-29 1991-10-23 Duphar International Research B.V L'application des bêta-carbolines, benzofurane et benzothiophène analogues pour obtenir un médicament à activité cytostatique

Also Published As

Publication number Publication date
IL87150A0 (en) 1988-12-30
CA1338189C (fr) 1996-03-26
ZA885146B (en) 1989-03-29
US5100884A (en) 1992-03-31
JPS6434984A (en) 1989-02-06
ATE136032T1 (de) 1996-04-15
EP0300541B1 (fr) 1996-03-27
EP0300541A1 (fr) 1989-01-25
NZ225421A (en) 1991-03-26
IL87150A (en) 1992-12-01
DK395888D0 (da) 1988-07-15
AU613059B2 (en) 1991-07-25
DE3855147D1 (de) 1996-05-02
AU1915288A (en) 1989-01-27

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