DK390689A - PROCEDURE FOR PREPARING DES-B30 INSULINES AND DES-B30 INSULIN DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING DES-B30 INSULINES AND DES-B30 INSULIN DERIVATIVES Download PDF

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Publication number
DK390689A
DK390689A DK390689A DK390689A DK390689A DK 390689 A DK390689 A DK 390689A DK 390689 A DK390689 A DK 390689A DK 390689 A DK390689 A DK 390689A DK 390689 A DK390689 A DK 390689A
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DK
Denmark
Prior art keywords
des
insulin derivatives
insulin
insulines
procedure
Prior art date
Application number
DK390689A
Other languages
Danish (da)
Other versions
DK390689D0 (en
Inventor
Wolfgang Gruenwald
Juergen Mueller-Lehar
Manfred Worm
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6360583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK390689(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK390689D0 publication Critical patent/DK390689D0/en
Publication of DK390689A publication Critical patent/DK390689A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

De-B30-insulins and de-B30-insulin derivatives are produced by enzymatic elimination of the B30 amino acid from insulins or insulin derivatives and of the B30 peptide residue from natural and unnatural insulin precursors in aqueous solution at pH values in the alkaline range in the absence of ammonium ions and at concentrations of the insulin starting materials above 5 mg/ml of reaction mixture.
DK390689A 1988-08-10 1989-08-09 PROCEDURE FOR PREPARING DES-B30 INSULINES AND DES-B30 INSULIN DERIVATIVES DK390689A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3827121A DE3827121A1 (en) 1988-08-10 1988-08-10 METHOD FOR PRODUCING DES-B30 INSULINES AND DES-B30 INSULINE DERIVATIVES

Publications (2)

Publication Number Publication Date
DK390689D0 DK390689D0 (en) 1989-08-09
DK390689A true DK390689A (en) 1990-02-11

Family

ID=6360583

Family Applications (1)

Application Number Title Priority Date Filing Date
DK390689A DK390689A (en) 1988-08-10 1989-08-09 PROCEDURE FOR PREPARING DES-B30 INSULINES AND DES-B30 INSULIN DERIVATIVES

Country Status (7)

Country Link
EP (1) EP0354507B1 (en)
JP (1) JPH02131594A (en)
KR (1) KR900003377A (en)
CN (1) CN1040222A (en)
AT (1) ATE95522T1 (en)
DE (2) DE3827121A1 (en)
DK (1) DK390689A (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
EP3508239B1 (en) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalant apparatus and atomizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5715640B2 (en) 2009-11-25 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
TWI455728B (en) * 2010-01-14 2014-10-11 Colgate Palmolive Co Dentifrice compositions
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
CN102703552B (en) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 Preparation method and products of recombinant human insulin
CN103509775A (en) * 2012-06-15 2014-01-15 上海抗体药物国家工程研究中心有限公司 Achromobacter protease I variant
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
WO2015018904A1 (en) 2013-08-09 2015-02-12 Boehringer Ingelheim International Gmbh Nebulizer
CN103467594A (en) * 2013-09-12 2013-12-25 深圳先进技术研究院 Insulin modifier and preparation method and application thereof
CN105087724B (en) * 2014-05-04 2019-12-03 重庆派金生物科技有限公司 The preparation method of yeast recombinant expression insulin aspart
BR112016023932B1 (en) 2014-05-07 2022-11-29 Boehringer Ingelheim International Gmbh NEBULIZER
JP6580070B2 (en) 2014-05-07 2019-09-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Container, nebulizer, and use
HUE055604T2 (en) 2014-05-07 2021-12-28 Boehringer Ingelheim Int Nebulizer
CN109735589B (en) * 2019-01-02 2020-07-10 珠海冀百康生物科技有限公司 Preparation method of insulin DesB30

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU469686A1 (en) * 1973-05-15 1975-05-05 Институт Экспериментальной Эндокринологии И Химии Гормонов Амн Ссср The method of obtaining des-alanine-in-30 insulin

Also Published As

Publication number Publication date
JPH02131594A (en) 1990-05-21
EP0354507B1 (en) 1993-10-06
DE3827121A1 (en) 1990-02-15
KR900003377A (en) 1990-03-26
DE58905821D1 (en) 1993-11-11
EP0354507A2 (en) 1990-02-14
EP0354507A3 (en) 1991-06-05
ATE95522T1 (en) 1993-10-15
CN1040222A (en) 1990-03-07
DK390689D0 (en) 1989-08-09

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