DE69429526D1 - SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF - Google Patents

SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF

Info

Publication number
DE69429526D1
DE69429526D1 DE69429526T DE69429526T DE69429526D1 DE 69429526 D1 DE69429526 D1 DE 69429526D1 DE 69429526 T DE69429526 T DE 69429526T DE 69429526 T DE69429526 T DE 69429526T DE 69429526 D1 DE69429526 D1 DE 69429526D1
Authority
DE
Germany
Prior art keywords
self
phosphate
calcium phosphate
production
cements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429526T
Other languages
German (de)
Other versions
DE69429526T2 (en
Inventor
C Chow
Shozo Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Dental Association Health Foundation
Original Assignee
American Dental Association Health Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Dental Association Health Foundation filed Critical American Dental Association Health Foundation
Publication of DE69429526D1 publication Critical patent/DE69429526D1/en
Application granted granted Critical
Publication of DE69429526T2 publication Critical patent/DE69429526T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/873—Carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
DE69429526T 1993-09-24 1994-09-23 SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF Expired - Lifetime DE69429526T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/126,502 US5525148A (en) 1993-09-24 1993-09-24 Self-setting calcium phosphate cements and methods for preparing and using them
PCT/US1994/010819 WO1995008319A1 (en) 1993-09-24 1994-09-23 Self-setting calcium phosphate cements and methods for preparing and using them

Publications (2)

Publication Number Publication Date
DE69429526D1 true DE69429526D1 (en) 2002-01-31
DE69429526T2 DE69429526T2 (en) 2002-08-08

Family

ID=22425179

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69429526T Expired - Lifetime DE69429526T2 (en) 1993-09-24 1994-09-23 SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
DE0721320T Pending DE721320T1 (en) 1993-09-24 1994-09-23 SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE0721320T Pending DE721320T1 (en) 1993-09-24 1994-09-23 SELF-HARDENING CALCIUM PHOSPHATE CEMENTS AND METHOD FOR THE PRODUCTION AND USE THEREOF

Country Status (9)

Country Link
US (4) US5525148A (en)
EP (1) EP0721320B1 (en)
JP (1) JPH10504467A (en)
AT (1) ATE210950T1 (en)
CA (1) CA2172538C (en)
DE (2) DE69429526T2 (en)
ES (1) ES2099687T1 (en)
GR (1) GR970300020T1 (en)
WO (1) WO1995008319A1 (en)

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ATE210950T1 (en) 2002-01-15
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WO1995008319A1 (en) 1995-03-30
US5997624A (en) 1999-12-07
EP0721320A1 (en) 1996-07-17
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EP0721320B1 (en) 2001-12-19
US5954867A (en) 1999-09-21
US5976234A (en) 1999-11-02
US5525148A (en) 1996-06-11
JPH10504467A (en) 1998-05-06
CA2172538A1 (en) 1995-03-30
CA2172538C (en) 1999-11-16
GR970300020T1 (en) 1997-07-30

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