DK371684A - Octahydroindolizin-propansyrer og dermed beslaegtede forbindelser til anvendelse som enzym-inhibitorer - Google Patents

Octahydroindolizin-propansyrer og dermed beslaegtede forbindelser til anvendelse som enzym-inhibitorer Download PDF

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Publication number
DK371684A
DK371684A DK371684A DK371684A DK371684A DK 371684 A DK371684 A DK 371684A DK 371684 A DK371684 A DK 371684A DK 371684 A DK371684 A DK 371684A DK 371684 A DK371684 A DK 371684A
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DK
Denmark
Prior art keywords
octahydroindolizin
propanic
enzym
inhibitors
acids
Prior art date
Application number
DK371684A
Other languages
English (en)
Other versions
DK371684D0 (da
Inventor
Jon Stuart Mynderse
David Shuichi Fukuda
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK371684D0 publication Critical patent/DK371684D0/da
Publication of DK371684A publication Critical patent/DK371684A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK371684A 1983-08-01 1984-07-31 Octahydroindolizin-propansyrer og dermed beslaegtede forbindelser til anvendelse som enzym-inhibitorer DK371684A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/519,360 US4594431A (en) 1983-08-01 1983-08-01 Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors

Publications (2)

Publication Number Publication Date
DK371684D0 DK371684D0 (da) 1984-07-31
DK371684A true DK371684A (da) 1985-02-02

Family

ID=24067968

Family Applications (1)

Application Number Title Priority Date Filing Date
DK371684A DK371684A (da) 1983-08-01 1984-07-31 Octahydroindolizin-propansyrer og dermed beslaegtede forbindelser til anvendelse som enzym-inhibitorer

Country Status (10)

Country Link
US (1) US4594431A (da)
EP (1) EP0133038A3 (da)
JP (1) JPS60115579A (da)
KR (1) KR870000340B1 (da)
CA (1) CA1257268A (da)
DK (1) DK371684A (da)
GB (1) GB2144421B (da)
GR (1) GR82660B (da)
HU (1) HU199461B (da)
IL (1) IL72487A (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334227A (en) * 1996-08-05 2000-10-27 Molecumetics Ltd Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US7498310B1 (en) 1998-08-13 2009-03-03 Beiersdorf Ag Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by UV radiation
EP1233967A4 (en) * 1999-11-19 2003-07-09 Univ Washington PYRIDINONES FOR THE TREATMENT AND PREVENTION OF BACTERIAL INFECTIONS
US6841559B1 (en) 1999-11-19 2005-01-11 Washington University Of St. Louis Pyridinones to treat and prevent bacterial infections
WO2005102330A2 (en) 2004-04-16 2005-11-03 Washingtion University Amino methylated 2-pyridinones

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274202A (en) * 1963-04-02 1966-09-20 Mcneilab Inc Certain octohydro-3-oxo-indolizines
US3297704A (en) * 1965-07-01 1967-01-10 Mcneilab Inc Octahydro-3-oxo indolizine carboxylates
US3494929A (en) * 1967-07-25 1970-02-10 American Home Prod 1-keto octahydroquinolizine-4-carboxylic acids
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
US4316906A (en) * 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4404282A (en) * 1982-08-19 1983-09-13 Eli Lilly And Company Process for enzyme inhibitor
US4404281A (en) * 1982-08-19 1983-09-13 Eli Lilly And Company Process for enzyme inhibitors
US4508901A (en) * 1982-08-19 1985-04-02 Eli Lilly And Company Quiuolizine and indolizine enzyme inhibitors

Also Published As

Publication number Publication date
GB2144421A (en) 1985-03-06
US4594431A (en) 1986-06-10
KR850002093A (ko) 1985-05-06
IL72487A0 (en) 1984-11-30
HU199461B (en) 1990-02-28
KR870000340B1 (ko) 1987-03-04
IL72487A (en) 1988-03-31
GR82660B (da) 1985-02-07
GB8419279D0 (en) 1984-08-30
DK371684D0 (da) 1984-07-31
GB2144421B (en) 1987-01-07
HUT34476A (en) 1985-03-28
JPS60115579A (ja) 1985-06-22
EP0133038A2 (en) 1985-02-13
EP0133038A3 (en) 1988-01-07
CA1257268A (en) 1989-07-11

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Legal Events

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AHS Application shelved for other reasons than non-payment