EP1233967A4 - Pyridinones to treat and prevent bacterial infections - Google Patents

Pyridinones to treat and prevent bacterial infections

Info

Publication number
EP1233967A4
EP1233967A4 EP00982170A EP00982170A EP1233967A4 EP 1233967 A4 EP1233967 A4 EP 1233967A4 EP 00982170 A EP00982170 A EP 00982170A EP 00982170 A EP00982170 A EP 00982170A EP 1233967 A4 EP1233967 A4 EP 1233967A4
Authority
EP
European Patent Office
Prior art keywords
pyridinones
treat
bacterial infections
prevent bacterial
prevent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00982170A
Other languages
German (de)
French (fr)
Other versions
EP1233967A1 (en
Inventor
Fredrik Almqvist
Hans Emtenas
Scott J Hultgren
Jerome S Pinkner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of EP1233967A1 publication Critical patent/EP1233967A1/en
Publication of EP1233967A4 publication Critical patent/EP1233967A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pyridine Compounds (AREA)
EP00982170A 1999-11-19 2000-11-20 Pyridinones to treat and prevent bacterial infections Withdrawn EP1233967A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16662199P 1999-11-19 1999-11-19
US166621P 1999-11-19
PCT/US2000/031879 WO2001036426A1 (en) 1999-11-19 2000-11-20 Pyridinones to treat and prevent bacterial infections

Publications (2)

Publication Number Publication Date
EP1233967A1 EP1233967A1 (en) 2002-08-28
EP1233967A4 true EP1233967A4 (en) 2003-07-09

Family

ID=22604044

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00982170A Withdrawn EP1233967A4 (en) 1999-11-19 2000-11-20 Pyridinones to treat and prevent bacterial infections

Country Status (4)

Country Link
EP (1) EP1233967A4 (en)
AU (1) AU1923501A (en)
CA (1) CA2390658A1 (en)
WO (1) WO2001036426A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10215336A1 (en) * 2002-03-28 2003-10-23 Schering Ag New S-protected N-methyl homocysteines useful as intermediates for peptide synthesis
AU2002364713A1 (en) 2001-12-04 2003-06-17 Corvas International, Inc. Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
DE10348022A1 (en) * 2003-10-15 2005-05-25 Imtm Gmbh New dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
JP2011519372A (en) * 2008-04-30 2011-07-07 フレードリク・アルムクヴィスト Novel peptide mimetic compounds
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
CN107074878B (en) * 2014-11-13 2019-12-24 快尔生物技术公司 2, 3-dihydro-thiazolo [3,2-a ] pyridin-5-one derivatives, intermediates thereof and their use as antibacterial agents
JP6979968B2 (en) * 2016-04-08 2021-12-15 キュアテック バイオ アーベーQuretech Bio Ab Ring-condensed thiazolino 2-pyridones, their production methods and their use in the treatment and / or prevention of tuberculosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD84850A (en) *
EP0133038A2 (en) * 1983-08-01 1985-02-13 Eli Lilly And Company Octahydroindolizinepropanoic acid derivatives as enzyme inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD84850A (en) *
EP0133038A2 (en) * 1983-08-01 1985-02-13 Eli Lilly And Company Octahydroindolizinepropanoic acid derivatives as enzyme inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAPPS N. K. ET AL.: "Synthesis of bicyclic pyridone and dihydropyridone analogs of .beta.-lactam antibiotics", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1., no. 12, 1991, CHEMICAL SOCIETY. LETCHWORTH., GB, pages 3077 - 3086, XP009003793, ISSN: 0300-922X *
FANG F.G. ET AL.: "Total synthesis of the angiotensin-converting enzyme inhibitor A58365A: on the use of pyroglutamate as a chiral educt", TETRAHEDRON LETTERS., vol. 30, no. 28, 1989, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 3621 - 3624, XP009004076, ISSN: 0040-4039 *
PADWA ET AL: "An Isomuenchnone-Based Method for the Synthesis of Highly Substituted 2(1H)-Pyridones", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 64, no. 23, 1999, pages 8648 - 8659, XP002177362, ISSN: 0022-3263 *
See also references of WO0136426A1 *

Also Published As

Publication number Publication date
AU1923501A (en) 2001-05-30
WO2001036426A1 (en) 2001-05-25
WO2001036426B1 (en) 2001-12-06
EP1233967A1 (en) 2002-08-28
CA2390658A1 (en) 2001-05-25

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020618

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HULTGREN, SCOTT, J.

Inventor name: ALMQVIST, FREDRIK

Inventor name: PINKNER, JEROME, S.

Inventor name: EMTENAS, HANS

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31/435 B

Ipc: 7C 07D 277/12 B

Ipc: 7C 07F 9/6561 B

Ipc: 7C 07D 279/06 B

Ipc: 7C 07D 498/04 B

Ipc: 7A 61P 31/04 B

Ipc: 7A 61K 31/429 B

Ipc: 7A 61K 31/542 B

Ipc: 7C 07D 471/04 B

Ipc: 7C 07D 513/04 A

A4 Supplementary search report drawn up and despatched

Effective date: 20030522

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HULTGREN, SCOTT, J.

Inventor name: EMTENAS, HANS

Inventor name: ALMQVIST, FREDERIK

Inventor name: PINKNER, JEROME, S.

17Q First examination report despatched

Effective date: 20041129

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050610