DK369287A - Immunotoksiner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem - Google Patents

Immunotoksiner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem

Info

Publication number
DK369287A
DK369287A DK369287A DK369287A DK369287A DK 369287 A DK369287 A DK 369287A DK 369287 A DK369287 A DK 369287A DK 369287 A DK369287 A DK 369287A DK 369287 A DK369287 A DK 369287A
Authority
DK
Denmark
Prior art keywords
immunotoxines
procedures
preparing
pharmaceutical agents
agents containing
Prior art date
Application number
DK369287A
Other languages
English (en)
Other versions
DK369287D0 (da
Inventor
Luigi Barbieri
Pierre Casellas
Fiorenzo Stirpe
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK369287D0 publication Critical patent/DK369287D0/da
Publication of DK369287A publication Critical patent/DK369287A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
    • A61K47/6823—Double chain ricin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK369287A 1986-07-15 1987-07-15 Immunotoksiner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem DK369287A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8610297A FR2601679B1 (fr) 1986-07-15 1986-07-15 Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
DK369287D0 DK369287D0 (da) 1987-07-15
DK369287A true DK369287A (da) 1988-01-16

Family

ID=9337440

Family Applications (1)

Application Number Title Priority Date Filing Date
DK369287A DK369287A (da) 1986-07-15 1987-07-15 Immunotoksiner og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende dem

Country Status (15)

Country Link
US (1) US4981953A (da)
EP (1) EP0255424B1 (da)
JP (1) JPS63146831A (da)
KR (1) KR880001299A (da)
AT (1) ATE67507T1 (da)
AU (1) AU614263B2 (da)
DE (1) DE3773077D1 (da)
DK (1) DK369287A (da)
ES (1) ES2040269T3 (da)
FR (1) FR2601679B1 (da)
GR (1) GR3003097T3 (da)
IL (1) IL83183A (da)
NZ (1) NZ221065A (da)
PT (1) PT85317B (da)
ZA (1) ZA875176B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635384A (en) * 1990-06-11 1997-06-03 Dowelanco Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
US5248606A (en) * 1990-06-11 1993-09-28 Dowelanco Dna encoding inactive precursor and active forms of maize ribosome inactivating protein
US5191066A (en) * 1990-12-07 1993-03-02 Abbott Laboratories Site-specific conjugation of immunoglobulins and detectable labels
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
DE4310142A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
DE69904831T2 (de) 1998-07-13 2003-11-06 Univ Texas Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
BR0010017A (pt) 1999-04-28 2002-06-11 Univ Texas Composições e processos para o tratamento de câncer por inibição seletiva de vegf
ES2331348T3 (es) * 2000-09-15 2009-12-30 Pasteur Institut Vectores proteinicos para el suministro de moleculas a las celulas que expresan cd11b.
KR100512870B1 (ko) * 2002-10-15 2005-09-07 주식회사 엔지켐 7α-메톡시세팔로스포린 유도체 나트륨염 7수화물의제조방법
WO2015006505A1 (en) 2013-07-09 2015-01-15 Oleksandr Gorbachov Power amplifier with input power protection circuits

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL47372A (en) * 1975-05-27 1979-10-31 Yeda Res & Dev Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same
JPS5843926A (ja) * 1981-09-08 1983-03-14 Suntory Ltd 選択性制癌剤
FR2566271B1 (fr) * 1984-06-20 1986-11-07 Sanofi Sa Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention
PT80662B (en) * 1984-06-20 1986-12-09 Sanofi Sa Process to obtain anti-tumoral glycoprotein modified on its glycidic portions
US4744981A (en) * 1985-10-17 1988-05-17 Neorx Corporation Trichothecene antibody conjugates

Also Published As

Publication number Publication date
IL83183A0 (en) 1987-12-31
DK369287D0 (da) 1987-07-15
AU7556487A (en) 1988-01-21
EP0255424B1 (fr) 1991-09-18
ES2040269T3 (es) 1993-10-16
US4981953A (en) 1991-01-01
NZ221065A (en) 1990-06-26
EP0255424A1 (fr) 1988-02-03
JPS63146831A (ja) 1988-06-18
ATE67507T1 (de) 1991-10-15
PT85317B (pt) 1990-04-30
DE3773077D1 (de) 1991-10-24
KR880001299A (ko) 1988-04-22
PT85317A (fr) 1987-08-01
FR2601679A1 (fr) 1988-01-22
IL83183A (en) 1992-05-25
AU614263B2 (en) 1991-08-29
FR2601679B1 (fr) 1990-05-25
GR3003097T3 (en) 1993-02-17
ZA875176B (en) 1988-03-30

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment