DK365578A - Fremgangsmaade til fremstilling af n-acyl-thienamyciner - Google Patents

Fremgangsmaade til fremstilling af n-acyl-thienamyciner

Info

Publication number
DK365578A
DK365578A DK365578A DK365578A DK365578A DK 365578 A DK365578 A DK 365578A DK 365578 A DK365578 A DK 365578A DK 365578 A DK365578 A DK 365578A DK 365578 A DK365578 A DK 365578A
Authority
DK
Denmark
Prior art keywords
thienamycines
acyl
procedure
preparation
Prior art date
Application number
DK365578A
Other languages
Danish (da)
English (en)
Inventor
J S Kahan
F M Kahan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK365578A publication Critical patent/DK365578A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK365578A 1977-08-19 1978-08-18 Fremgangsmaade til fremstilling af n-acyl-thienamyciner DK365578A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/825,884 US4135978A (en) 1977-08-19 1977-08-19 Production of n-acyl-thienamycins

Publications (1)

Publication Number Publication Date
DK365578A true DK365578A (da) 1979-02-20

Family

ID=25245141

Family Applications (1)

Application Number Title Priority Date Filing Date
DK365578A DK365578A (da) 1977-08-19 1978-08-18 Fremgangsmaade til fremstilling af n-acyl-thienamyciner

Country Status (9)

Country Link
US (1) US4135978A (fr)
EP (1) EP0000932B1 (fr)
JP (1) JPS5455789A (fr)
DE (1) DE2861197D1 (fr)
DK (1) DK365578A (fr)
ES (1) ES472702A1 (fr)
IE (1) IE47152B1 (fr)
IT (1) IT7850748A0 (fr)
PT (1) PT68429A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207395A (en) * 1978-11-02 1980-06-10 Merck & Co., Inc. Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
JPS585189A (ja) * 1981-07-01 1983-01-12 Sanraku Inc 新規なアミドヒドロラ−ゼ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB939708A (en) * 1961-06-01 1963-10-16 Beecham Res Lab Production of ª -hydroxybenzylpenicillin
CH475284A (de) * 1963-11-19 1969-07-15 Ciba Geigy Verfahren zur Herstellung von Desacetyl-7-amino-cephalosporansäure
JPS4944351B1 (fr) * 1969-10-24 1974-11-27
JPS5417030B2 (fr) * 1972-12-06 1979-06-27
GB1474519A (fr) * 1973-05-14 1977-05-25
JPS5713280B2 (fr) * 1974-03-11 1982-03-16
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
EP0000932A1 (fr) 1979-03-07
JPS5455789A (en) 1979-05-04
US4135978A (en) 1979-01-23
PT68429A (en) 1978-09-01
IT7850748A0 (it) 1978-08-16
ES472702A1 (es) 1979-02-16
IE47152B1 (en) 1983-12-28
IE781673L (en) 1979-02-19
EP0000932B1 (fr) 1981-10-21
DE2861197D1 (en) 1981-12-24

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Legal Events

Date Code Title Description
ATS Application withdrawn