DK3625213T3 - (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof - Google Patents

(+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof Download PDF

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Publication number
DK3625213T3
DK3625213T3 DK18730980.2T DK18730980T DK3625213T3 DK 3625213 T3 DK3625213 T3 DK 3625213T3 DK 18730980 T DK18730980 T DK 18730980T DK 3625213 T3 DK3625213 T3 DK 3625213T3
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DK
Denmark
Prior art keywords
methoxypyrrolidine
difluorophenyl
fumarate
preparation
methoxypyrrolidine fumarate
Prior art date
Application number
DK18730980.2T
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Danish (da)
English (en)
Inventor
Clas Sonesson
Maija Buksa
Inese Reine
Original Assignee
Integrative Res Laboratories Sweden Ab
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Application filed by Integrative Res Laboratories Sweden Ab filed Critical Integrative Res Laboratories Sweden Ab
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Publication of DK3625213T3 publication Critical patent/DK3625213T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK18730980.2T 2017-05-19 2018-05-18 (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof DK3625213T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17171938 2017-05-19
EP17195451 2017-10-09
EP17207406 2017-12-14
EP18151428 2018-01-12
PCT/EP2018/063123 WO2018211080A1 (en) 2017-05-19 2018-05-18 (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine or pharmaceutically acceptable salts thereof, a process for preparation thereof and uses thereof

Publications (1)

Publication Number Publication Date
DK3625213T3 true DK3625213T3 (da) 2023-04-24

Family

ID=62599537

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18730980.2T DK3625213T3 (da) 2017-05-19 2018-05-18 (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof

Country Status (9)

Country Link
US (3) US11078158B2 (enExample)
EP (1) EP3625213B1 (enExample)
JP (1) JP7126522B2 (enExample)
CN (1) CN110621659B (enExample)
DK (1) DK3625213T3 (enExample)
ES (1) ES2943252T3 (enExample)
FI (1) FI3625213T3 (enExample)
PL (1) PL3625213T3 (enExample)
WO (1) WO2018211080A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12275694B2 (en) * 2019-05-24 2025-04-15 Irl 790 Ab Pharmaceutically acceptable salts of [2-(3-fluoro-5-methane-sulfonylphenoxy)ethyl](propyl)amine and uses thereof
CA3180417A1 (en) * 2020-06-10 2021-12-16 Guillaume Dutheuil Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid
CN117430540A (zh) * 2022-07-14 2024-01-23 上海艾力斯医药科技股份有限公司 一种吡咯烷化合物及其制备方法
WO2025003437A1 (en) 2023-06-28 2025-01-02 Integrative Research Laboratories Sweden Ab A pharmaceutical composition comprising a fumaric acid salt of (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
EP1582524B1 (en) 2004-04-02 2008-08-13 Ludwig Maximilians Universität Method of preparing organomagnesium compounds
AU2008258599B2 (en) * 2007-06-05 2013-06-13 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
WO2010058019A1 (en) * 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
CN106957252B (zh) * 2014-11-19 2019-11-19 连云港恒运药业有限公司 一种质子泵抑制剂中间体及其制备方法

Also Published As

Publication number Publication date
US20240400505A1 (en) 2024-12-05
JP7126522B2 (ja) 2022-08-26
CN110621659A (zh) 2019-12-27
US20210317081A1 (en) 2021-10-14
EP3625213A1 (en) 2020-03-25
WO2018211080A1 (en) 2018-11-22
CN110621659B (zh) 2023-02-28
US11078158B2 (en) 2021-08-03
CA3064136A1 (en) 2018-11-22
JP2020520936A (ja) 2020-07-16
EP3625213B1 (en) 2023-03-08
US12091384B2 (en) 2024-09-17
PL3625213T3 (pl) 2023-07-17
US20200024231A1 (en) 2020-01-23
FI3625213T3 (fi) 2023-05-29
ES2943252T3 (es) 2023-06-12

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