DK3581645T3 - Fremgangsmåde til at fremme diversifikation af en antistof variabel region - Google Patents
Fremgangsmåde til at fremme diversifikation af en antistof variabel region Download PDFInfo
- Publication number
- DK3581645T3 DK3581645T3 DK18750887.4T DK18750887T DK3581645T3 DK 3581645 T3 DK3581645 T3 DK 3581645T3 DK 18750887 T DK18750887 T DK 18750887T DK 3581645 T3 DK3581645 T3 DK 3581645T3
- Authority
- DK
- Denmark
- Prior art keywords
- variable region
- antibody variable
- diversification
- promoting
- promoting diversification
- Prior art date
Links
- 230000001737 promoting effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017023001 | 2017-02-10 | ||
| PCT/JP2018/004697 WO2018147432A1 (ja) | 2017-02-10 | 2018-02-09 | 抗体可変領域の多様化を促進する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3581645T3 true DK3581645T3 (da) | 2021-11-15 |
Family
ID=63106932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18750887.4T DK3581645T3 (da) | 2017-02-10 | 2018-02-09 | Fremgangsmåde til at fremme diversifikation af en antistof variabel region |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11572402B2 (da) |
| EP (2) | EP3974521A1 (da) |
| JP (2) | JP7071740B2 (da) |
| CN (1) | CN110291191B (da) |
| DK (1) | DK3581645T3 (da) |
| ES (1) | ES2895641T3 (da) |
| WO (1) | WO2018147432A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109890842B (zh) * | 2016-09-30 | 2023-12-22 | 凯奥目生物科学株式会社 | 抗体的取得方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122339B2 (en) | 1998-10-09 | 2006-10-17 | Medical Research Council | Method for generating diversity |
| US20050246782A1 (en) * | 2002-03-22 | 2005-11-03 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
| EP1536004B1 (en) | 2002-07-30 | 2010-12-01 | Riken | Method of promoting homologous recombination of somatic cells and method of constructing specific antibody |
| AU2002343870A1 (en) | 2002-11-07 | 2004-06-07 | Kumamoto Technology And Industry Foundation | Transgenic mammal carrying ganp and utilization thereof |
| JP4487068B2 (ja) | 2004-10-12 | 2010-06-23 | 国立大学法人 岡山大学 | 細胞の遺伝子変異機能の制御による変異タンパク質の作製方法 |
| JP2008099602A (ja) | 2006-10-19 | 2008-05-01 | Institute Of Physical & Chemical Research | 抗体遺伝子の可変領域における変異部位の分布状況の調節法 |
| ES2628973T3 (es) | 2007-05-31 | 2017-08-04 | University Of Washington | Mutagénesis inducible de genes diana |
| JP2009060850A (ja) | 2007-09-06 | 2009-03-26 | Okayama Univ | Ｂ細胞の抗体遺伝子変異様式の転換方法 |
| SG196798A1 (en) * | 2008-12-09 | 2014-02-13 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| US9719099B2 (en) | 2012-08-10 | 2017-08-01 | E I Du Pont De Nemours And Company | Soybean CCP1 promoter and its use in constitutive expression of transgenic genes in plants |
| ES2728854T3 (es) | 2013-02-06 | 2019-10-29 | Univ Yokohama City | Anticuerpo anti-semaforina 3A y tratamiento de enfermedad de Alzheimer y enfermedades inmunitarias inflamatorias usando el mismo |
| CN112877292A (zh) | 2014-05-02 | 2021-06-01 | 凯奥目生物科学株式会社 | 产生人抗体的细胞 |
-
2018
- 2018-02-09 ES ES18750887T patent/ES2895641T3/es active Active
- 2018-02-09 JP JP2018567520A patent/JP7071740B2/ja active Active
- 2018-02-09 EP EP21193090.4A patent/EP3974521A1/en active Pending
- 2018-02-09 DK DK18750887.4T patent/DK3581645T3/da active
- 2018-02-09 CN CN201880010943.9A patent/CN110291191B/zh active Active
- 2018-02-09 EP EP18750887.4A patent/EP3581645B1/en active Active
- 2018-02-09 US US16/484,061 patent/US11572402B2/en active Active
- 2018-02-09 WO PCT/JP2018/004697 patent/WO2018147432A1/ja unknown
-
2022
- 2022-04-26 JP JP2022072176A patent/JP2022103201A/ja active Pending
-
2023
- 2023-01-03 US US18/149,439 patent/US20230220049A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN110291191B (zh) | 2023-09-12 |
| EP3974521A1 (en) | 2022-03-30 |
| EP3581645A4 (en) | 2020-12-16 |
| JP7071740B2 (ja) | 2022-05-19 |
| US20190359691A1 (en) | 2019-11-28 |
| JP2022103201A (ja) | 2022-07-07 |
| EP3581645A1 (en) | 2019-12-18 |
| JPWO2018147432A1 (ja) | 2019-11-21 |
| WO2018147432A1 (ja) | 2018-08-16 |
| ES2895641T3 (es) | 2022-02-22 |
| CN110291191A (zh) | 2019-09-27 |
| US11572402B2 (en) | 2023-02-07 |
| US20230220049A1 (en) | 2023-07-13 |
| EP3581645B1 (en) | 2021-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3277717T3 (da) | En hidtil ukendt il33-form, muterede former af il33, antistoffer, assays og fremgangsmåder til anvendelse deraf | |
| DK3565844T3 (da) | Fremgangsmåder til behandling af cancer med anti-PD-1-antistoffer | |
| CL2018000370A1 (es) | Nuevos anticuerpos anti-pd-1 | |
| DK3455257T3 (da) | Anti-pd-l1-antistoffer | |
| DK3315610T3 (da) | Fremgangsmåde til fremstilling af fucosylerede oligosaccharider | |
| DK3332006T3 (da) | Hidtil ukendte anti-PD-L1-antistoffer | |
| DK3478286T3 (da) | Fremgangsmåder til behandling af ovariecancer | |
| DK3292134T3 (da) | Metode til dyrkning af akkermansia | |
| DK3556775T3 (da) | Anti-lag-3 antistoffer til behandling af hæmatologiske maligniteter | |
| DK3441086T3 (da) | Monoklonalt anti-PD-1-antistof | |
| DK3292153T3 (da) | Kombination af en cd30xcd16a-antistof med en anti-pd-1 antagonistisk antistof til behandling | |
| DK3458100T3 (da) | Selektiv reduktion af cystein-manipulerede antistoffer | |
| DK3368683T3 (da) | Fremgangsmåde til kvantifikationen af pd-l1 | |
| DK3515990T3 (da) | Fremgangsmåde til fremstilling af lignocellulosematerialer | |
| DK3487443T3 (da) | Fremgangsmåde til opmåling af en implantat-implantat-situation | |
| DK3529227T3 (da) | Fremgangsmåde til fremstilling af diener | |
| DK3612845T3 (da) | Fremgangsmåde til kontaktløs bestemmelse af flowparametre | |
| DK3728585T3 (da) | Hidtil ukendte fremgangsmåder til fremstilling af oligonukleotider | |
| DK3384045T3 (da) | Fremgangsmåde til bestemmelse af celleklonalitet | |
| DK3277801T3 (da) | Fremgangsmåde til fremstilling af otiske progenitorer | |
| DK3226609T3 (da) | Fremgangsmåde til scheduling af køretøj-til-køretøj-kommunikationer | |
| DK3337820T3 (da) | Forbedret fremgangsmåde til genfoldning af fragmenter af antistoffer | |
| DK3567245T3 (da) | Drift af vindmølle | |
| DK3265439T3 (da) | Fremgangsmåde til fremstilling af 3-chlor-2-vinylphenylsulfonater | |
| ITUB20155097A1 (it) | Anticorpi umanizzati anti-BAG3 |