DK3564267T3 - Proteolytisk, spaltbar fusionsprotein med høj molær specifik aktivitet - Google Patents
Proteolytisk, spaltbar fusionsprotein med høj molær specifik aktivitet Download PDFInfo
- Publication number
- DK3564267T3 DK3564267T3 DK19162362.8T DK19162362T DK3564267T3 DK 3564267 T3 DK3564267 T3 DK 3564267T3 DK 19162362 T DK19162362 T DK 19162362T DK 3564267 T3 DK3564267 T3 DK 3564267T3
- Authority
- DK
- Denmark
- Prior art keywords
- proteolytic
- fusion protein
- specific activity
- high molar
- cleavable fusion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06012262A EP1867660A1 (en) | 2006-06-14 | 2006-06-14 | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
US81962006P | 2006-07-11 | 2006-07-11 | |
EP10168453.8A EP2256135B1 (en) | 2006-06-14 | 2007-06-14 | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3564267T3 true DK3564267T3 (da) | 2021-05-31 |
Family
ID=37450975
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07726010.7T DK2032607T4 (da) | 2006-06-14 | 2007-06-14 | Proteolytisk spalteligt fusionsprotein omfattende en blodkoagulerings-faktor |
DK19162362.8T DK3564267T3 (da) | 2006-06-14 | 2007-06-14 | Proteolytisk, spaltbar fusionsprotein med høj molær specifik aktivitet |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07726010.7T DK2032607T4 (da) | 2006-06-14 | 2007-06-14 | Proteolytisk spalteligt fusionsprotein omfattende en blodkoagulerings-faktor |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090042787A1 (da) |
EP (3) | EP1867660A1 (da) |
DK (2) | DK2032607T4 (da) |
ES (2) | ES2468558T5 (da) |
PL (1) | PL3564267T3 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
EP2007885B1 (en) * | 2006-04-11 | 2010-07-21 | CSL Behring GmbH | Method of increasing the in vivo recovery of therapeutic polypeptides |
US7939632B2 (en) * | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
JP5448839B2 (ja) * | 2006-12-22 | 2014-03-19 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | インビボで長い半減期を有する修飾された凝固因子 |
US20100268055A1 (en) * | 2007-07-19 | 2010-10-21 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Self-Anchoring MEMS Intrafascicular Neural Electrode |
CN102076855A (zh) * | 2008-06-24 | 2011-05-25 | Csl百灵有限公司 | 具有延长的体内半衰期的因子viii,冯·维勒布兰德因子或它们的复合物 |
WO2010083536A1 (en) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase-cleavable bioprotective moiety |
US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
DK2393828T3 (en) | 2009-02-03 | 2017-01-23 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
ES2705249T3 (es) | 2009-06-08 | 2019-03-22 | Amunix Operating Inc | Polipéptidos reguladores de glucosa y métodos para su producción y uso |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
JP2013517782A (ja) * | 2010-01-28 | 2013-05-20 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 因子vii融合ポリペプチド |
EP2371857A1 (en) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
KR101853405B1 (ko) | 2010-10-20 | 2018-05-02 | 주식회사 티움바이오 | 인자 ix 활성을 갖는 융합 단백질 |
KR102212098B1 (ko) * | 2012-01-12 | 2021-02-03 | 바이오버라티브 테라퓨틱스 인크. | 키메라 인자 viii 폴리펩티드들과 이의 용도 |
US10370430B2 (en) | 2012-02-15 | 2019-08-06 | Bioverativ Therapeutics Inc. | Recombinant factor VIII proteins |
SG11201404885RA (en) | 2012-02-15 | 2014-09-26 | Amunix Operating Inc | Factor viii compositions and methods of making and using same |
EP2950813B1 (en) | 2013-01-31 | 2019-09-04 | Pfizer Inc | Compositions and methods for counteracting factor xa inhibition |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
CA2928762A1 (en) * | 2013-11-01 | 2015-05-07 | The Children's Hospital Of Philadelphia | Compositions and methods for increasing the half-life of factor xa |
WO2015073727A1 (en) * | 2013-11-13 | 2015-05-21 | Aequus Biopharma, Inc. | Engineered glycoproteins and uses thereof |
BR112016015512B1 (pt) | 2014-01-10 | 2023-12-19 | Bioverativ Therapeutics Inc | Proteína quimérica, composição farmacêutica e seus usos |
US10676731B2 (en) | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
AU2016321146C1 (en) * | 2015-09-08 | 2021-10-28 | Theripion, Inc. | ApoA-1 fusion polypeptides and related compositions and methods |
AU2019271149B2 (en) * | 2018-05-14 | 2023-07-13 | Werewolf Therapeutics, Inc. | Activatable interleukin 12 polypeptides and methods of use thereof |
JP7460609B2 (ja) | 2018-05-14 | 2024-04-02 | ウェアウルフ セラピューティクス, インコーポレイテッド | 活性化可能なインターロイキン-2ポリペプチド及びその使用方法 |
MX2021013766A (es) | 2019-05-14 | 2022-02-21 | Werewolf Therapeutics Inc | Restos de separacion y metodos de uso de los mismos. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
ATE198712T1 (de) * | 1994-07-11 | 2001-02-15 | Univ Texas | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen |
AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2001275897A1 (en) | 2000-07-12 | 2002-01-21 | Immunex Corporation | Improvement of cell culture performance |
AU2002359816B2 (en) | 2001-12-21 | 2006-07-13 | Immunex Corporation | Methods for purifying protein |
CN101044154A (zh) | 2002-02-14 | 2007-09-26 | 威廉·J·鲁特 | 治疗宿主中切割的嵌合分子 |
US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
EP1444986A1 (en) * | 2003-02-07 | 2004-08-11 | Aventis Behring GmbH | Pharmaceutical preparation for the improved treatment of blood-clotting disorders |
US20050176108A1 (en) | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
ES2558102T3 (es) * | 2003-05-06 | 2016-02-02 | Biogen Hemophilia Inc. | Proteínas quiméricas del factor de coagulación para el tratamiento de un trastorno hemostático |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
CN1871252A (zh) | 2003-09-05 | 2006-11-29 | Gtc生物治疗学公司 | 在转基因哺乳动物奶中生产融合蛋白的方法 |
EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
-
2006
- 2006-06-14 EP EP06012262A patent/EP1867660A1/en not_active Withdrawn
-
2007
- 2007-06-14 EP EP10168453.8A patent/EP2256135B1/en active Active
- 2007-06-14 ES ES07726010.7T patent/ES2468558T5/es active Active
- 2007-06-14 US US11/812,016 patent/US20090042787A1/en not_active Abandoned
- 2007-06-14 PL PL19162362T patent/PL3564267T3/pl unknown
- 2007-06-14 DK DK07726010.7T patent/DK2032607T4/da active
- 2007-06-14 EP EP19162362.8A patent/EP3564267B1/en active Active
- 2007-06-14 ES ES10168453T patent/ES2729426T3/es active Active
- 2007-06-14 DK DK19162362.8T patent/DK3564267T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP2256135A1 (en) | 2010-12-01 |
EP2256135B1 (en) | 2019-03-13 |
EP3564267B1 (en) | 2021-03-17 |
ES2468558T3 (es) | 2014-06-16 |
DK2032607T4 (da) | 2017-05-15 |
ES2729426T3 (es) | 2019-11-04 |
PL3564267T3 (pl) | 2021-10-11 |
DK2032607T3 (da) | 2014-04-14 |
EP3564267A1 (en) | 2019-11-06 |
EP1867660A1 (en) | 2007-12-19 |
US20090042787A1 (en) | 2009-02-12 |
ES2468558T5 (es) | 2017-07-18 |
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