DK3558954T3 - Forbedret proces til fremstilling af r-6-hydroxy-8-[1-hydroxy-2-[2-(4methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride - Google Patents

Forbedret proces til fremstilling af r-6-hydroxy-8-[1-hydroxy-2-[2-(4methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride Download PDF

Info

Publication number
DK3558954T3
DK3558954T3 DK17816861.3T DK17816861T DK3558954T3 DK 3558954 T3 DK3558954 T3 DK 3558954T3 DK 17816861 T DK17816861 T DK 17816861T DK 3558954 T3 DK3558954 T3 DK 3558954T3
Authority
DK
Denmark
Prior art keywords
hydroxy
4drochone
4drocho
3dyhone
dimethylethylaminoethyl
Prior art date
Application number
DK17816861.3T
Other languages
Danish (da)
English (en)
Inventor
Urbaneja Enric Capdevila
Clotet Juan Huguet
Barjoan Pere Dalmases
Original Assignee
Inke Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke Sa filed Critical Inke Sa
Application granted granted Critical
Publication of DK3558954T3 publication Critical patent/DK3558954T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/245Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255Tartaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK17816861.3T 2016-12-20 2017-12-19 Forbedret proces til fremstilling af r-6-hydroxy-8-[1-hydroxy-2-[2-(4methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride DK3558954T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16382628 2016-12-20
EP17382449 2017-07-10
PCT/EP2017/083444 WO2018114887A1 (en) 2016-12-20 2017-12-19 Improved process for the manufacture of r-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride

Publications (1)

Publication Number Publication Date
DK3558954T3 true DK3558954T3 (da) 2021-12-06

Family

ID=60702800

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17816861.3T DK3558954T3 (da) 2016-12-20 2017-12-19 Forbedret proces til fremstilling af r-6-hydroxy-8-[1-hydroxy-2-[2-(4methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride

Country Status (9)

Country Link
US (1) US10800748B2 (enExample)
EP (1) EP3558954B1 (enExample)
JP (1) JP7116060B2 (enExample)
CN (1) CN110114346B (enExample)
DK (1) DK3558954T3 (enExample)
ES (1) ES2900283T3 (enExample)
HR (1) HRP20211915T1 (enExample)
PL (1) PL3558954T3 (enExample)
WO (1) WO2018114887A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108997248B (zh) * 2018-08-06 2023-08-01 上海方予健康医药科技有限公司 盐酸奥达特罗晶型b及其制备方法
CN108822054B (zh) * 2018-08-06 2021-06-22 上海方予健康医药科技有限公司 盐酸奥达特罗晶型c及其制备方法
CN109096218B (zh) * 2018-08-06 2020-10-27 上海方予健康医药科技有限公司 盐酸奥达特罗晶型a及其制备方法
CN114057590A (zh) * 2021-11-12 2022-02-18 安徽有吉医药科技有限公司 一种奥达特罗关键中间体的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10253282A1 (de) 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
MX2008001976A (es) * 2005-08-15 2008-03-25 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos.
PL2125759T3 (pl) 2007-01-25 2011-12-30 Boehringer Ingelheim Int Sposób wytwarzania związków betamimetycznych
US20100249550A1 (en) 2009-03-25 2010-09-30 Neilcor Puritan Bennett LLC Method And Apparatus For Optical Filtering Of A Broadband Emitter In A Medical Sensor

Also Published As

Publication number Publication date
US10800748B2 (en) 2020-10-13
JP2020502077A (ja) 2020-01-23
CN110114346A (zh) 2019-08-09
JP7116060B2 (ja) 2022-08-09
HRP20211915T1 (hr) 2022-03-18
US20200062723A1 (en) 2020-02-27
ES2900283T3 (es) 2022-03-16
CN110114346B (zh) 2023-10-31
EP3558954A1 (en) 2019-10-30
EP3558954B1 (en) 2021-11-03
PL3558954T3 (pl) 2022-01-31
WO2018114887A1 (en) 2018-06-28

Similar Documents

Publication Publication Date Title
HUE056676T2 (hu) 2-(morfolin-4-il)-1,7-naftiridinek
DK3558954T3 (da) Forbedret proces til fremstilling af r-6-hydroxy-8-[1-hydroxy-2-[2-(4methoxyphenyl)-1,1-dimethylethylaminoethyl]-2h-1,4-benzoxazin-3(4h)-one hydrochloride
IL247833A0 (en) 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
DK3448999T3 (da) Oligonukleotider til behandling af øjensygdom
DK2988743T3 (da) Heterocykliske forbindelser, der kan anvendes til behandling af sygdom
MX2017012021A (es) Compuestos antifungicos y procesos para la fabricacion.
MA44759A (fr) Forme polymorphe de n-{6-(2-hydroxypropan-2-yl)-2-[2-(méthylsulfonyl)éthyl]-2h-indazol-5-yl}-6-(trifluorométhyl)pyridine-2-carboxamide
DK3600499T3 (da) Overvågning af en injektionsproces
EP3434263A4 (en) PROCESS FOR PREPARING A MICROPARTICLE WITH DELAYED RELEASE
DK3297631T3 (da) NK-1/NK-3-receptorantagonist til behandling af hedeture
DK3227273T3 (da) Sammensætninger, som omfatter 2-((1-(2(4-fluorphenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-on, til behanlding af skizofreni
DK3227294T3 (da) 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4h-pyrrolo[3,2-d]pyrimidin-4-oner som inhibitorer af myeloperoxidase
DK3104847T3 (da) Hidtil ukendt anvendelse af sigma-1-receptoragonistforbindelser
DK3099302T3 (da) Krystallinske former af 2-(tert-butylamino)-4-((1r, 3r, 4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidin-5-carboxamid
DK3765440T3 (da) Fremgangsmåde til fremstilling af n-alkyl-nitratoethylnitraminer
DK3373931T3 (da) Heterocykliske forbindelser til behandling af sygdom
EP3357563A4 (en) SEPARATING FOIL, CELLULOSE BASE RESIN COMPOSITION AND METHOD FOR PRODUCING THE SEPARATING FOIL
DK3634463T3 (da) Forbedret protokol til behandling af lupus nephritis
DK3397621T3 (da) Fremgangsmåde til fremstilling af 1,1,3-trioxo-1,2-benzothiazol-6-carboxamid
DK3558953T3 (da) Fremgangsmåde til fremstillingen af 2-(3-(alkyl og alkenyl)morpholino)-ethan-1-oler
DK3275023T3 (da) Fremgangsmåde til fremstilling af ledninger af højtemperatur-superledere
EP3455287A4 (en) BENZOTHIAZOLES AS LATENT CATALYSTS FOR BENZOXAZINE RESINS
DK3396380T3 (da) Diagnostisk værktøj til bestemmelse af udslettelse af podocytfodprocesser
DK3620452T3 (da) Fremgangsmåde til fremstilling af lenvatinib
DK3402775T5 (da) Fremgangsmåde til fremstilling af 2-(4-chlor-2,6-dimethylphenyl)ethanol