DK3558335T3 - Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions - Google Patents
Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions Download PDFInfo
- Publication number
- DK3558335T3 DK3558335T3 DK17883876.9T DK17883876T DK3558335T3 DK 3558335 T3 DK3558335 T3 DK 3558335T3 DK 17883876 T DK17883876 T DK 17883876T DK 3558335 T3 DK3558335 T3 DK 3558335T3
- Authority
- DK
- Denmark
- Prior art keywords
- caspase
- inhibition
- prevention
- treatment
- neurological conditions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438529P | 2016-12-23 | 2016-12-23 | |
| US201762579936P | 2017-11-01 | 2017-11-01 | |
| PCT/CA2017/051548 WO2018112626A1 (en) | 2016-12-23 | 2017-12-20 | Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3558335T3 true DK3558335T3 (da) | 2023-07-24 |
Family
ID=62624456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17883876.9T DK3558335T3 (da) | 2016-12-23 | 2017-12-20 | Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11160788B2 (da) |
| EP (1) | EP3558335B1 (da) |
| JP (1) | JP7213555B2 (da) |
| KR (1) | KR102590456B1 (da) |
| CN (1) | CN110545835A (da) |
| AU (1) | AU2017383127A1 (da) |
| CA (1) | CA3047836C (da) |
| DK (1) | DK3558335T3 (da) |
| ES (1) | ES2950100T3 (da) |
| FI (1) | FI3558335T3 (da) |
| PL (1) | PL3558335T3 (da) |
| PT (1) | PT3558335T (da) |
| WO (1) | WO2018112626A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3176737A1 (en) | 2020-05-01 | 2021-11-04 | Thomas M. FISHBEIN | Methods for treating covid-19 |
| EP4165037A4 (en) | 2020-06-10 | 2024-07-03 | Aligos Therapeutics Inc | ANTIVIRAL COMPOUNDS FOR THE TREATMENT OF CORONAVIRUS, PICORNAVIRUS AND NOROVIRUS INFECTIONS |
| IL309732A (en) | 2021-07-09 | 2024-02-01 | Aligos Therapeutics Inc | Antiviral compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1064298E (pt) | 1998-03-19 | 2009-01-02 | Vertex Pharma | Inibidores de caspasas |
| IL152393A (en) | 2000-04-24 | 2008-03-20 | Vertex Pharma | Process for making aspartic acid acetal derivatives |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| KR100538780B1 (ko) | 2002-09-10 | 2005-12-23 | 주식회사 브레인트로피아 | 미노사이클린을 유효성분으로 함유하는 치매 및 기억력감퇴의 예방 및 치료용 조성물 |
| JP4898658B2 (ja) | 2004-03-12 | 2012-03-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
| CN1980658A (zh) | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 治疗自身炎性疾病的ice抑制剂 |
| PL2245026T3 (pl) | 2008-02-07 | 2013-01-31 | Boehringer Ingelheim Int | Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji |
| US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
| WO2012061786A1 (en) | 2010-11-05 | 2012-05-10 | Brandeis University | Ice cleaved alpha-synuclein a biomarker |
| ES2907620T3 (es) | 2011-07-18 | 2022-04-25 | Univ Kentucky Res Found | Protección de células de la degeneración inducida por ARN Alu e inhibidores para proteger células |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
-
2017
- 2017-12-20 CA CA3047836A patent/CA3047836C/en active Active
- 2017-12-20 FI FIEP17883876.9T patent/FI3558335T3/fi active
- 2017-12-20 PT PT178838769T patent/PT3558335T/pt unknown
- 2017-12-20 AU AU2017383127A patent/AU2017383127A1/en active Pending
- 2017-12-20 KR KR1020197021496A patent/KR102590456B1/ko active IP Right Grant
- 2017-12-20 JP JP2019555521A patent/JP7213555B2/ja active Active
- 2017-12-20 CN CN201780084390.7A patent/CN110545835A/zh active Pending
- 2017-12-20 WO PCT/CA2017/051548 patent/WO2018112626A1/en unknown
- 2017-12-20 DK DK17883876.9T patent/DK3558335T3/da active
- 2017-12-20 ES ES17883876T patent/ES2950100T3/es active Active
- 2017-12-20 EP EP17883876.9A patent/EP3558335B1/en active Active
- 2017-12-20 US US16/471,047 patent/US11160788B2/en active Active
- 2017-12-20 PL PL17883876.9T patent/PL3558335T3/pl unknown
-
2021
- 2021-09-30 US US17/449,526 patent/US20220054454A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3047836C (en) | 2024-02-06 |
| ES2950100T3 (es) | 2023-10-05 |
| KR102590456B1 (ko) | 2023-10-17 |
| CN110545835A (zh) | 2019-12-06 |
| PT3558335T (pt) | 2023-07-20 |
| US20190328709A1 (en) | 2019-10-31 |
| US11160788B2 (en) | 2021-11-02 |
| JP7213555B2 (ja) | 2023-01-27 |
| US20220054454A1 (en) | 2022-02-24 |
| WO2018112626A1 (en) | 2018-06-28 |
| EP3558335A1 (en) | 2019-10-30 |
| JP2020502282A (ja) | 2020-01-23 |
| KR20190099497A (ko) | 2019-08-27 |
| AU2017383127A1 (en) | 2019-07-11 |
| CA3047836A1 (en) | 2018-06-28 |
| PL3558335T3 (pl) | 2023-08-21 |
| FI3558335T3 (fi) | 2023-07-19 |
| EP3558335B1 (en) | 2023-04-19 |
| EP3558335A4 (en) | 2020-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL266273A (en) | Systems and methods for treating excess fluids | |
| IL298690B1 (en) | Preparations and methods for suppressing masp-3 for the treatment of various diseases and conditions | |
| GB2554629B (en) | Prevention and treatment of microbial infections | |
| ZA201908165B (en) | Compounds for the prevention and treatment of diseases and the use thereof | |
| DK3558280T3 (da) | Forebyggelse og behandling af migræne | |
| ZA201901055B (en) | Treatment and prevention of sleep disorders | |
| IL263477A (en) | Compositions and methods for the treatment or prevention of oxalate-related disorders | |
| DK3558335T3 (da) | Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions | |
| ZA202000558B (en) | Prevention and/or treatment of neurodegenerative disease | |
| EP3723742C0 (fr) | Utilisation de la fluoroethylnormemantine pour la prevention et le traitement de l'anxiete | |
| PL3183003T3 (pl) | SPOSOBY ZAPOBIEGANIA l/LUB LECZENIA ZAKAŻENIA | |
| HK1243961A1 (zh) | 炎性病况的預防和治療 | |
| PL3504163T3 (pl) | Oczyszczanie ścieków | |
| EP3377062C0 (en) | AMINONAPHHOQUINONE COMPOUNDS FOR THE TREATMENT AND/OR PREVENTION OF FIBROSIS DISEASES | |
| GB201615298D0 (en) | Treatment and prevention of Malaria | |
| GB201719969D0 (en) | Prevention and/or treatment of neurodegenerative disease | |
| GB201815000D0 (en) | Treatment of hypothroidism and related conditions | |
| GB201522828D0 (en) | Prevention and treatment of glaucoma | |
| ITUB20160141A1 (it) | Composizione per la prevenzione ed il trattamento di cefalee primarie | |
| SG11201705889VA (en) | Prevention or Treatment of Uratic or Gouty Diseases | |
| GB201519483D0 (en) | Prevention and treatment of microbial infections | |
| GB201518252D0 (en) | Prevention and treatment of microbial infections | |
| GB201513047D0 (en) | Prevention and treatment of microbial infections | |
| GB201511576D0 (en) | Prevention and treatment of microbial infections | |
| GB201509654D0 (en) | Prevention and treatment of microbial infections |