DK3524601T3 - N-{3-[3-cyclopropyl-5-(2-fluor-4-iodphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropancarboxamid-dimethyl-sulphoxidsolvat som en mek1/2-inhibitor - Google Patents

N-{3-[3-cyclopropyl-5-(2-fluor-4-iodphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropancarboxamid-dimethyl-sulphoxidsolvat som en mek1/2-inhibitor Download PDF

Info

Publication number
DK3524601T3
DK3524601T3 DK16918763.0T DK16918763T DK3524601T3 DK 3524601 T3 DK3524601 T3 DK 3524601T3 DK 16918763 T DK16918763 T DK 16918763T DK 3524601 T3 DK3524601 T3 DK 3524601T3
Authority
DK
Denmark
Prior art keywords
dimethyl
cyclopropancarboxamid
mec1
iodophenylamino
trioxo
Prior art date
Application number
DK16918763.0T
Other languages
English (en)
Inventor
Alexandre Vasilievich Ivachtchenko
Vasily Gennadievich Ignatiev
Mikhail Airatovich Chafeev
Alexey Evgenievich Repik
Original Assignee
R Pharm Joint Stock Company R Pharm Jsc
Alexey Evgenievich Repik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Pharm Joint Stock Company R Pharm Jsc, Alexey Evgenievich Repik filed Critical R Pharm Joint Stock Company R Pharm Jsc
Application granted granted Critical
Publication of DK3524601T3 publication Critical patent/DK3524601T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16918763.0T 2016-10-10 2016-12-12 N-{3-[3-cyclopropyl-5-(2-fluor-4-iodphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropancarboxamid-dimethyl-sulphoxidsolvat som en mek1/2-inhibitor DK3524601T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2016139641A RU2627692C1 (ru) 2016-10-10 2016-10-10 N-{ 3-[3-циклопропил-5-(2-фторо-4-иодофениламино)-6,8-диметил-2,4,7-триоксо-3,4,6,7-тетрагидро-2Н-пиридо[4,3-d]пиримидин-1-ил]-фенил} -циклопропанкарбоксамида диметилсульфоксида сольват в качестве ингибитора МЕК1/2
PCT/RU2016/000862 WO2018070900A1 (ru) 2016-10-10 2016-12-12 N-{3-[3-циклопропил-5-(2-фторо-4-иодофениламино)-6,8-диметил-2,4,7-триоксо-3,4,6,7-тетрагидро-2н-пиридо[4,3-d]пиримидин-1-ил]-фенил}-циклопропанкарбоксамида диметилсульфоксида сольват в качестве ингибитора мек1/2

Publications (1)

Publication Number Publication Date
DK3524601T3 true DK3524601T3 (da) 2021-11-08

Family

ID=59641667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16918763.0T DK3524601T3 (da) 2016-10-10 2016-12-12 N-{3-[3-cyclopropyl-5-(2-fluor-4-iodphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropancarboxamid-dimethyl-sulphoxidsolvat som en mek1/2-inhibitor

Country Status (27)

Country Link
US (1) US10738049B2 (da)
EP (1) EP3524601B1 (da)
JP (1) JP6909299B2 (da)
KR (1) KR102387288B1 (da)
CN (1) CN110012668B (da)
AU (1) AU2016426350B2 (da)
BR (1) BR112019007223A2 (da)
CA (1) CA3039524A1 (da)
CO (1) CO2019004688A2 (da)
CY (1) CY1125283T1 (da)
DK (1) DK3524601T3 (da)
EA (1) EA037939B1 (da)
ES (1) ES2898026T3 (da)
HR (1) HRP20211693T1 (da)
HU (1) HUE056490T2 (da)
LT (1) LT3524601T (da)
MA (1) MA46440B1 (da)
MD (1) MD3524601T2 (da)
MX (1) MX2019004137A (da)
PH (1) PH12019500721A1 (da)
PL (1) PL3524601T3 (da)
PT (1) PT3524601T (da)
RS (1) RS62604B1 (da)
RU (1) RU2627692C1 (da)
SI (1) SI3524601T1 (da)
WO (1) WO2018070900A1 (da)
ZA (1) ZA201902861B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230293463A1 (en) 2022-03-17 2023-09-21 SpringWorks Therapeutics Inc. Treatment of cutaneous neurofibromas with Mirdametinib
CN114853754B (zh) * 2022-05-23 2023-04-18 云白药征武科技(上海)有限公司 一种硫代酰胺衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
CN101912400B (zh) 2004-06-11 2013-06-26 日本烟草产业株式会社 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物
TWI505828B (zh) * 2010-12-20 2015-11-01 葛蘭素史克智慧財產（第二）有限公司 新穎醫藥組成物
CA2889530A1 (en) * 2012-10-25 2014-05-01 Glaxosmithkline Llc Combination
RU2605400C1 (ru) * 2015-11-13 2016-12-20 ЗАО "Р-Фарм" ПРОИЗВОДНЫЕ 1-(3-АМИНОФЕНИЛ)-6,8-ДИМЕТИЛ-5-(4-ИОД-2-ФТОР-ФЕНИЛАМИНО)-3-ЦИКЛОПРОПИЛ-1H,6H-ПИРИДО[4,3-d]ПИРИМИДИН-2,4,7-ТРИОНА В КАЧЕСТВЕ ИНГИБИТОРОВ МЕК1/2

Also Published As

Publication number Publication date
SI3524601T1 (sl) 2022-02-28
EP3524601A4 (en) 2020-03-11
WO2018070900A1 (ru) 2018-04-19
US20190233415A1 (en) 2019-08-01
KR20190062512A (ko) 2019-06-05
EA201900158A1 (ru) 2019-08-30
RS62604B1 (sr) 2021-12-31
PH12019500721A1 (en) 2019-12-02
ZA201902861B (en) 2021-06-30
JP2019531350A (ja) 2019-10-31
HUE056490T2 (hu) 2022-02-28
KR102387288B1 (ko) 2022-04-14
PT3524601T (pt) 2021-11-03
MA46440B1 (fr) 2021-11-30
HRP20211693T1 (hr) 2022-02-04
CY1125283T1 (el) 2023-03-24
JP6909299B2 (ja) 2021-07-28
ES2898026T3 (es) 2022-03-03
US10738049B2 (en) 2020-08-11
AU2016426350B2 (en) 2020-08-27
MX2019004137A (es) 2019-09-26
EP3524601A1 (en) 2019-08-14
EA037939B1 (ru) 2021-06-09
CA3039524A1 (en) 2018-04-19
RU2627692C1 (ru) 2017-08-10
EP3524601B1 (en) 2021-10-13
LT3524601T (lt) 2021-12-27
MD3524601T2 (ro) 2022-02-28
CO2019004688A2 (es) 2019-05-21
CN110012668B (zh) 2021-11-26
AU2016426350A1 (en) 2019-05-30
CN110012668A (zh) 2019-07-12
PL3524601T3 (pl) 2022-03-21
MA46440A (fr) 2021-06-02
BR112019007223A2 (pt) 2019-07-02

Similar Documents

Publication Publication Date Title
EP3189609A4 (en) Wireless local area network with spatial diagnostics
EP3852343C0 (en) METHODS FOR PROVIDING A WIRELESS BEACON
EP3332517A4 (en) DEEP PACKAGE TEST ADVICE FOR A MOBILE CONTENT NETWORK
GB201516998D0 (en) Moving tools on offshore structures
EP3105731A4 (en) Event-based offers for a geofenced geographic area
ZA201804221B (en) A collapsible bed base
EP3350242B8 (de) Verfahren zur herstellung eines polyurethan-polyisocyanurat-hartschaums
GB201603863D0 (en) A workbench
DK3524601T3 (da) N-{3-[3-cyclopropyl-5-(2-fluor-4-iodphenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]-phenyl}-cyclopropancarboxamid-dimethyl-sulphoxidsolvat som en mek1/2-inhibitor
PL3153813T3 (pl) Pomiar względnych odchyleń współśrodkowości w ograniczonej przestrzeni pomiędzy dwoma elementami obwodowymi
GB201519252D0 (en) A proximity beacon
GB201513154D0 (en) Hole forming tool
GB2568432B (en) A hole forming tool
GB2557139B (en) A method of assessing the condition of a tubular member
PL3478485T3 (pl) Sposób wytwarzania opony
GB201616375D0 (en) Wi-Fi access point with bluetooth beacon
HUP1700073A2 (en) Agrochemical solid formulation
ZA201607371B (en) A vehicle jack
PL3164709T3 (pl) Identyfikacja związków modyfikujących fenotyp komórek
GB2559011B (en) Testing a vehicle
IL253002B (en) A method for measuring the distance between two mobile nodes establishing a uwb radio connection
EP3115165C0 (en) ENLARGED HOLE SECTION FORMING DEVICE
GB201616548D0 (en) A probe
GB201602239D0 (en) Cinema designer tool
GB201616376D0 (en) Bluetooth beacon