DK348489A - PROCEDURE FOR THE PREPARATION OF (S) -CYAN HYDRAINES - Google Patents

PROCEDURE FOR THE PREPARATION OF (S) -CYAN HYDRAINES Download PDF

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Publication number
DK348489A
DK348489A DK348489A DK348489A DK348489A DK 348489 A DK348489 A DK 348489A DK 348489 A DK348489 A DK 348489A DK 348489 A DK348489 A DK 348489A DK 348489 A DK348489 A DK 348489A
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DK
Denmark
Prior art keywords
reaction
preparation
hydraines
cyan
procedure
Prior art date
Application number
DK348489A
Other languages
Danish (da)
Other versions
DK348489D0 (en
Inventor
Maria-Regina Kula
Uwe Niedermeyer
Ingeborg Maria Stuertz
Original Assignee
Kernforschungsanlage Juelich
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19883823866 external-priority patent/DE3823866A1/en
Application filed by Kernforschungsanlage Juelich, Degussa filed Critical Kernforschungsanlage Juelich
Publication of DK348489D0 publication Critical patent/DK348489D0/en
Publication of DK348489A publication Critical patent/DK348489A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The preparation of (S)-cyanohydrins by reaction of the corresponding oxo compounds with hydrocyanic acid can be achieved enzymatically with the aid of oxynitrilase (4.1.2.11) from Sorghum bicolor. This is preferably carried out in aqueous medium at pH values below 6.0, in particular below 4.5, in order to suppress competing chemical reactions and racemisations. The reaction temperatures are, in particular, between -5 DEG C and +50 DEG C. Of particular interest is the reaction of aromatic aldehydes, specifically benzaldehyde and its derivatives, and the generation of aldononitriles by reaction of aldoses, especially of sugars with 3 to 9 carbon atoms, with hydrocyanic acid.
DK348489A 1988-07-14 1989-07-13 PROCEDURE FOR THE PREPARATION OF (S) -CYAN HYDRAINES DK348489A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19883823866 DE3823866A1 (en) 1988-07-14 1988-07-14 Process for the preparation of S-cyanohydrins
DE3917374A DE3917374A1 (en) 1988-07-14 1989-05-29 METHOD FOR PRODUCING S-CYANHYDRINES

Publications (2)

Publication Number Publication Date
DK348489D0 DK348489D0 (en) 1989-07-13
DK348489A true DK348489A (en) 1990-01-15

Family

ID=25870080

Family Applications (1)

Application Number Title Priority Date Filing Date
DK348489A DK348489A (en) 1988-07-14 1989-07-13 PROCEDURE FOR THE PREPARATION OF (S) -CYAN HYDRAINES

Country Status (7)

Country Link
EP (1) EP0350908B1 (en)
JP (1) JPH02223546A (en)
AT (1) ATE123531T1 (en)
AU (1) AU615318B2 (en)
BR (1) BR8903445A (en)
DE (2) DE3917374A1 (en)
DK (1) DK348489A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823864A1 (en) * 1988-01-29 1989-08-10 Kernforschungsanlage Juelich ENYMATIC PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CYANHYDRINES
DE4008412C1 (en) * 1990-03-16 1991-07-18 Forschungszentrum Juelich Gmbh, 5170 Juelich, De Optically active cyanohydrin prepn. useful insecticidal derivs. - comprising condensation of oxo-cpd. with hydrogen cyanide in presence of (R)- or (S) oxynitrilase
EP0446826B1 (en) * 1990-03-16 1995-11-15 Forschungszentrum Jülich Gmbh Process for the production of optical active cyanhydrin
US5177242A (en) * 1991-12-17 1993-01-05 Fmc Corporation Process for preparing optically active cyanohydrins with enzymes
AT400035B (en) * 1993-06-01 1995-09-25 Chemie Linz Gmbh ENZYMATIC METHOD FOR PRODUCING ALIPHATIC S-CYANHYDRINE
DE4322064A1 (en) * 1993-07-02 1995-01-12 Chemie Linz Deutschland Enzymatic process for the preparation of aliphatic S-cyanohydrins
DE59711628D1 (en) 1996-02-09 2004-06-24 Degussa Process for the preparation of (S) -cyanohydrins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300111B (en) * 1965-04-07 1969-07-31 Pfeil Process for the preparation of optically active cyanohydrins
DE1593260A1 (en) * 1966-09-19 1969-09-25 Becker Dr Wolfgang Method and catalyst for preparing cyanohydrins and method for preparing the catalyst
ZA889493B (en) * 1987-12-24 1989-09-27 Duphar Int Res Method of preparing optically active cyanohydrin derivatives and their conversion products,and optically active compounds to be obtained in this manner
DE3823864A1 (en) * 1988-01-29 1989-08-10 Kernforschungsanlage Juelich ENYMATIC PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CYANHYDRINES

Also Published As

Publication number Publication date
ATE123531T1 (en) 1995-06-15
DK348489D0 (en) 1989-07-13
EP0350908A2 (en) 1990-01-17
DE3917374A1 (en) 1990-12-06
BR8903445A (en) 1990-03-13
JPH02223546A (en) 1990-09-05
EP0350908A3 (en) 1991-07-31
AU3810489A (en) 1990-01-18
EP0350908B1 (en) 1995-06-07
AU615318B2 (en) 1991-09-26
DE58909279D1 (en) 1995-07-13

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