DK3320105T3 - Celler, der producerer glycoproteiner med ændrede o- og o-glycosyleringsmønstre, samt tilhørende fremgangsmåder og anvendelse - Google Patents
Celler, der producerer glycoproteiner med ændrede o- og o-glycosyleringsmønstre, samt tilhørende fremgangsmåder og anvendelse Download PDFInfo
- Publication number
- DK3320105T3 DK3320105T3 DK16739080.6T DK16739080T DK3320105T3 DK 3320105 T3 DK3320105 T3 DK 3320105T3 DK 16739080 T DK16739080 T DK 16739080T DK 3320105 T3 DK3320105 T3 DK 3320105T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycosyling
- patterns
- changed
- well
- cells producing
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99001—Beta-galactoside alpha-2,6-sialyltransferase (2.4.99.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
- C12Y501/03002—UDP-glucose 4-epimerase (5.1.3.2), i.e. UDP-galactose 4-epimerase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/00051—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15176111 | 2015-07-09 | ||
PCT/EP2016/066362 WO2017005925A1 (en) | 2015-07-09 | 2016-07-08 | Cells producing glycoproteins having altered n- and o-glycosylation patterns and methods and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3320105T3 true DK3320105T3 (da) | 2021-06-07 |
Family
ID=53525143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16739080.6T DK3320105T3 (da) | 2015-07-09 | 2016-07-08 | Celler, der producerer glycoproteiner med ændrede o- og o-glycosyleringsmønstre, samt tilhørende fremgangsmåder og anvendelse |
Country Status (9)
Country | Link |
---|---|
US (1) | US11293012B2 (da) |
EP (1) | EP3320105B1 (da) |
JP (1) | JP6790057B2 (da) |
KR (1) | KR102564610B1 (da) |
CN (1) | CN108026558B (da) |
AU (1) | AU2016290670B2 (da) |
CA (1) | CA2991368C (da) |
DK (1) | DK3320105T3 (da) |
WO (1) | WO2017005925A1 (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6790057B2 (ja) | 2015-07-09 | 2020-11-25 | ブイアイビー ブイゼットダブリュVib Vzw | 改変されたn−およびo−グリコシル化パターンを有する糖タンパク質を産生する細胞ならびにその方法および使用 |
JP2020519261A (ja) | 2017-05-11 | 2020-07-02 | ブイアイビー ブイゼットダブリュVib Vzw | 可変免疫グロブリンドメインのグリコシル化 |
EP3682017A2 (en) * | 2017-09-14 | 2020-07-22 | Vib Vzw | Genetically engineered eukaryotic cells producing lacnac-glycoproteins |
GB201714765D0 (en) * | 2017-09-14 | 2017-11-01 | Vib Vzw | Means and methods for the production of glycoproteins comprising homogeneous sialylated carbonhydrates |
CN108982737B (zh) * | 2018-08-07 | 2021-06-22 | 中国人民解放军军事科学院军事医学研究院 | 一种规模化的核心岩藻糖基化修饰位点占有率定量方法 |
GB201901608D0 (en) | 2019-02-06 | 2019-03-27 | Vib Vzw | Vaccine adjuvant conjugates |
GB201918279D0 (en) | 2019-12-12 | 2020-01-29 | Vib Vzw | Glycosylated single chain immunoglobulin domains |
CN115177739B (zh) * | 2022-02-22 | 2024-04-30 | 中南大学湘雅医院 | 一种组织-细胞-细胞器三级靶向的仿生制剂及其制备方法和应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE177788T1 (de) | 1991-12-23 | 1999-04-15 | Gist Brocades Nv | Eukaryotisches expressionssystem |
US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
AU784960B2 (en) | 1999-08-19 | 2006-08-10 | Kirin Pharma Kabushiki Kaisha | Novel yeast variants and process for producing glycoprotein containing mammalian type sugar chain |
EP1297172B1 (en) | 2000-06-28 | 2005-11-09 | Glycofi, Inc. | Methods for producing modified glycoproteins |
US7795002B2 (en) * | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
DE10062302A1 (de) | 2000-12-14 | 2002-07-11 | Aventis Res & Tech Gmbh & Co | Sekretionssignalpeptide, deren DNA-Sequenzen, damit herstellbare Expressionsvektoren für eukaryotische Zellen und deren Verwendung zur biotechnologischen Herstellung von Proteinen |
CA2468295C (en) | 2001-11-28 | 2010-08-03 | Neose Technologies, Inc. | Glycoprotein remodeling using endoglycanases |
ES2498369T3 (es) | 2002-04-16 | 2014-09-24 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Un marcador para medir cirrosis hepática |
WO2003091431A1 (fr) | 2002-04-26 | 2003-11-06 | Kirin Beer Kabushiki Kaisha | Methylotrophe produisant une chaine de sucre de type mammifere |
PT1583968E (pt) | 2003-01-14 | 2015-09-14 | Vzw Vib | Um marcador sérico para medição da fibrose hepática |
US20080220473A1 (en) | 2004-11-10 | 2008-09-11 | Universiteit Gent | Endo-N-Acetyl-Beta-D-Glucosaminidase Enzymes of Filamentous Fungi |
EP2001358B1 (en) | 2006-03-27 | 2016-07-13 | University Of Maryland, Baltimore | Glycoprotein synthesis and remodeling by enzymatic transglycosylation |
CA2733362C (en) * | 2008-08-08 | 2016-10-18 | Universiteit Gent | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
EP2401378B1 (en) * | 2009-02-25 | 2013-08-14 | Merck Sharp & Dohme Corp. | Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris |
WO2011157761A1 (en) | 2010-06-17 | 2011-12-22 | Vib Vzw | Increased protein expression through increased membrane formation |
EP2617732A1 (en) | 2012-01-19 | 2013-07-24 | Vib Vzw | Tools and methods for expression of membrane proteins |
WO2015032899A1 (en) | 2013-09-05 | 2015-03-12 | Vib Vzw | Cells producing fc containing molecules having altered glycosylation patterns and methods and use thereof |
JP6790057B2 (ja) | 2015-07-09 | 2020-11-25 | ブイアイビー ブイゼットダブリュVib Vzw | 改変されたn−およびo−グリコシル化パターンを有する糖タンパク質を産生する細胞ならびにその方法および使用 |
-
2016
- 2016-07-08 JP JP2018500741A patent/JP6790057B2/ja active Active
- 2016-07-08 CN CN201680052097.8A patent/CN108026558B/zh active Active
- 2016-07-08 AU AU2016290670A patent/AU2016290670B2/en active Active
- 2016-07-08 WO PCT/EP2016/066362 patent/WO2017005925A1/en active Application Filing
- 2016-07-08 DK DK16739080.6T patent/DK3320105T3/da active
- 2016-07-08 KR KR1020187003915A patent/KR102564610B1/ko active IP Right Grant
- 2016-07-08 CA CA2991368A patent/CA2991368C/en active Active
- 2016-07-08 US US15/741,025 patent/US11293012B2/en active Active
- 2016-07-08 EP EP16739080.6A patent/EP3320105B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20180025969A (ko) | 2018-03-09 |
CA2991368A1 (en) | 2017-01-12 |
JP6790057B2 (ja) | 2020-11-25 |
AU2016290670B2 (en) | 2020-11-05 |
JP2018524985A (ja) | 2018-09-06 |
US11293012B2 (en) | 2022-04-05 |
CN108026558B (zh) | 2021-08-17 |
US20180187177A1 (en) | 2018-07-05 |
WO2017005925A1 (en) | 2017-01-12 |
EP3320105B1 (en) | 2021-03-10 |
CN108026558A (zh) | 2018-05-11 |
AU2016290670A1 (en) | 2018-02-01 |
KR102564610B1 (ko) | 2023-08-07 |
EP3320105A1 (en) | 2018-05-16 |
CA2991368C (en) | 2023-05-23 |
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