DK3319651T3 - Vaskulariserede in vitro perfusionsindretninger, fremgangsmåder til fremstilling og anvendelser deraf - Google Patents

Vaskulariserede in vitro perfusionsindretninger, fremgangsmåder til fremstilling og anvendelser deraf Download PDF

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Publication number
DK3319651T3
DK3319651T3 DK16821889.9T DK16821889T DK3319651T3 DK 3319651 T3 DK3319651 T3 DK 3319651T3 DK 16821889 T DK16821889 T DK 16821889T DK 3319651 T3 DK3319651 T3 DK 3319651T3
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Denmark
Prior art keywords
vascularized
manufacture
methods
perfusion devices
vitro perfusion
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DK16821889.9T
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English (en)
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Michael W Golway
James B Hoying
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Advanced Solutions Life Sciences Llc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/069Vascular Endothelial cells
    • C12N5/0691Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064Endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
DK16821889.9T 2015-07-06 2016-07-06 Vaskulariserede in vitro perfusionsindretninger, fremgangsmåder til fremstilling og anvendelser deraf DK3319651T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562188803P 2015-07-06 2015-07-06
US201662279019P 2016-01-15 2016-01-15
PCT/US2016/041034 WO2017007786A1 (en) 2015-07-06 2016-07-06 Vascularized in vitro perfusion devices, methods of fabricating, and applications thereof

Publications (1)

Publication Number Publication Date
DK3319651T3 true DK3319651T3 (da) 2022-07-18

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ID=57686133

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16821889.9T DK3319651T3 (da) 2015-07-06 2016-07-06 Vaskulariserede in vitro perfusionsindretninger, fremgangsmåder til fremstilling og anvendelser deraf

Country Status (11)

Country Link
US (2) US10392595B2 (da)
EP (1) EP3319651B1 (da)
JP (1) JP6917975B2 (da)
KR (1) KR102530274B1 (da)
AU (1) AU2016289944B2 (da)
CA (1) CA2991297A1 (da)
DK (1) DK3319651T3 (da)
ES (1) ES2922905T3 (da)
IL (1) IL256673B (da)
PL (1) PL3319651T3 (da)
WO (1) WO2017007786A1 (da)

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US10159765B2 (en) * 2013-10-25 2018-12-25 The Board Of Regents Of The University Of Texas System Tissue engineered devices and methods for making same
WO2018132720A1 (en) * 2017-01-13 2018-07-19 The Penn State Research Foundation Organ models
AU2018233180B2 (en) * 2017-03-15 2023-12-14 Aspect Biosystems Ltd. Systems and methods for printing a fiber structure
CA3059983C (en) * 2017-04-14 2023-09-05 Advanced Solutions Life Sciences, Llc Vascularized in vitro arrays of living cells
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
EP3684915A4 (en) * 2017-09-19 2021-06-30 Cornell University MANUFACTURING OF A BIOMIMETIC PLATFORM SYSTEM AND METHODS OF USE
GB201801582D0 (en) * 2018-01-31 2018-03-14 Univ Leuven Kath Devices and methods for three-dimensional growth of cells
KR102441083B1 (ko) 2018-03-08 2022-09-06 현대자동차주식회사 크랭크샤프트용 댐퍼풀리
EP3775154A4 (en) * 2018-03-26 2021-12-22 The Trustees of the University of Pennsylvania SYSTEMS AND METHODS FOR A MULTI-WAY VASCULAR SYSTEM
CN110607271B (zh) * 2018-06-14 2023-01-20 中国科学院大连化学物理研究所 一种基于微加工技术的体外血管化3d组织的制备方法
CN110713921B (zh) * 2018-07-13 2022-12-20 复旦大学 一套体外动态的药物代谢孵育系统
SE543308C2 (en) * 2018-12-11 2020-11-24 Cellink Ab Microfluidic device facilitating perfusion of mammalian and human tissue constructs
WO2020185576A1 (en) * 2019-03-08 2020-09-17 Advanced Solutions Life Sciences, Llc Modular and expandable low flow pumping assemblies
WO2020205567A1 (en) * 2019-03-29 2020-10-08 Advanced Solutions Life Sciences, Llc Systems and methods for biomedical object segmentation
JP2022536892A (ja) * 2019-06-18 2022-08-22 スリーディー バイオラブズ,エルエルシー マイクロチャネル導管ネットワークデバイスの製作およびマイクロチャネルへの播種のためのシステムならびに方法
GB202004177D0 (en) * 2020-03-16 2020-05-06 Imp College Innovations Ltd Device for perfusion and preservation of tissue specimens ex vivo
EP4146783A1 (en) * 2020-05-05 2023-03-15 3D Systems, Inc. Microcosm bio-scaffold and applications thereof
KR102520786B1 (ko) * 2020-05-27 2023-04-13 한국재료연구원 3차원 구조체 내부 관류 가능 미세 혈관 생성을 위한 바이오리액팅 시스템
WO2022015854A2 (en) * 2020-07-15 2022-01-20 Advanced Solutions Life Sciences, Llc Methods of identifying therapeutic targets for treating angiogenesis
US20220135951A1 (en) * 2020-11-04 2022-05-05 The University Of Kansas Renal tube assay device and methods of manufacture and use
WO2022155337A1 (en) * 2021-01-15 2022-07-21 The Trustees Of Indiana University A device having a support structure for creating a hollow, three-dimensional organoids and cultures
US20220284832A1 (en) * 2021-03-05 2022-09-08 Advanced Solutions Life Sciences, Llc Models and methods to establish perfused vascularized tissues in three-dimensional in vitro culture
AU2022351688A1 (en) * 2021-09-24 2024-04-04 3D Systems, Inc. Manifolds, systems and methods for conducting biological studies under flow
WO2023133523A2 (en) * 2022-01-07 2023-07-13 South Dakota Board Of Regents Physiologically-relevant, serum-free in vitro angiogenesis platform
WO2023140719A1 (ko) * 2022-01-24 2023-07-27 울산과학기술원 바이오 스캐폴드 제조용 미세유체 장치 및 이의 용도
WO2024044348A1 (en) * 2022-08-26 2024-02-29 Chunguang Xia System and method for perfusion bioreactor for 3d cell culture

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JPH02261375A (ja) * 1989-04-03 1990-10-24 Terumo Corp 血管新生活性を有する細胞および血管新生活性物ならびにその製造方法
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Also Published As

Publication number Publication date
EP3319651A4 (en) 2018-10-24
KR102530274B1 (ko) 2023-05-08
JP2018532371A (ja) 2018-11-08
IL256673A (en) 2018-02-28
PL3319651T3 (pl) 2022-11-14
US10392595B2 (en) 2019-08-27
AU2016289944A1 (en) 2018-02-01
US20170009194A1 (en) 2017-01-12
IL256673B (en) 2021-12-01
CA2991297A1 (en) 2017-01-12
EP3319651B1 (en) 2022-05-11
KR20180027553A (ko) 2018-03-14
AU2016289944B2 (en) 2020-05-07
WO2017007786A1 (en) 2017-01-12
ES2922905T3 (es) 2022-09-21
EP3319651A1 (en) 2018-05-16
JP6917975B2 (ja) 2021-08-11
US20190330583A1 (en) 2019-10-31

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