DK317287A - Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse - Google Patents

Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse

Info

Publication number
DK317287A
DK317287A DK317287A DK317287A DK317287A DK 317287 A DK317287 A DK 317287A DK 317287 A DK317287 A DK 317287A DK 317287 A DK317287 A DK 317287A DK 317287 A DK317287 A DK 317287A
Authority
DK
Denmark
Prior art keywords
hmg
pharmaceutical preparation
coa reductase
preparation containing
reductase inhibitors
Prior art date
Application number
DK317287A
Other languages
English (en)
Other versions
DK317287D0 (da
Inventor
Edward S Inamine
David R Houck
Otto D Hensens
Ta-Jyh Lee
Wasyl Halczenko
George D Hartman
Robert L Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27357040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK317287(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK317287D0 publication Critical patent/DK317287D0/da
Publication of DK317287A publication Critical patent/DK317287A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
DK317287A 1986-06-23 1987-06-22 Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse DK317287A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87704186A 1986-06-23 1986-06-23
US193387A 1987-01-09 1987-01-09
US4813687A 1987-05-15 1987-05-15

Publications (2)

Publication Number Publication Date
DK317287D0 DK317287D0 (da) 1987-06-22
DK317287A true DK317287A (da) 1987-12-24

Family

ID=27357040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK317287A DK317287A (da) 1986-06-23 1987-06-22 Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse

Country Status (7)

Country Link
EP (1) EP0251625B1 (da)
KR (1) KR880000586A (da)
AU (1) AU7455987A (da)
CA (1) CA1340331C (da)
DE (1) DE3770345D1 (da)
DK (1) DK317287A (da)
PT (1) PT85109A (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4795811A (en) * 1987-06-22 1989-01-03 Merck & Co., Inc. Intermediates for preparing HMG-CoA reductase inhibitors
PT88364A (pt) * 1987-09-02 1989-07-31 Merck & Co Inc Process for preparing novel hmg-coa reductase inhibitors
DE3869282D1 (de) * 1987-09-02 1992-04-23 Merck & Co Inc Inhibitoren von hmg-coa-reduktase.
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
US4857546A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4866090A (en) * 1988-01-07 1989-09-12 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4866068A (en) * 1988-02-01 1989-09-12 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4946864A (en) * 1988-02-01 1990-08-07 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US5049696A (en) * 1988-04-11 1991-09-17 Merck & Co., Inc. Antihypercholesterolemic compounds
US4997755A (en) * 1988-04-15 1991-03-05 Merck & Co., Inc. HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
FI893004A (fi) * 1988-06-29 1989-12-30 Merck & Co Inc 5-oxygenerade hmg-coa-reduktas -inhibitorer.
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5001148A (en) * 1989-06-07 1991-03-19 E. R. Squibb & Sons, Inc. Mevinic acid derivatives
IL90847A0 (en) * 1989-06-09 1990-02-09 Merck & Co Inc 3-keto hmg-coa reductase inhibitors and pharmaceutical compositions containing them
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
US5264455A (en) * 1990-07-06 1993-11-23 E. R. Squibb & Sons, Inc. Sulfur-substituted mevinic acid derivatives
GB9100174D0 (en) * 1991-01-04 1991-02-20 British Bio Technology Compounds
GB9111192D0 (en) * 1991-05-23 1991-07-17 British Bio Technology Synthetic process
US5286746A (en) * 1991-12-20 1994-02-15 E. R. Squibb & Sons, Inc. Sulfur-substituted mevinic acid derivatives
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
EP1083894A1 (en) 1998-06-08 2001-03-21 Advanced Medicine, Inc. MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE
PL346392A1 (en) * 1999-06-29 2002-02-11 Kaneka Corp Process for selective lactonization
KR20200066690A (ko) 2017-10-16 2020-06-10 칭화대학교 메발로네이트 경로 억제제 및 이의 약제학적 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4611068A (en) * 1984-11-19 1986-09-09 Merck Frosst Canada, Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein

Also Published As

Publication number Publication date
KR880000586A (ko) 1988-03-28
EP0251625A2 (en) 1988-01-07
DK317287D0 (da) 1987-06-22
DE3770345D1 (de) 1991-07-04
EP0251625A3 (en) 1989-01-25
CA1340331C (en) 1999-01-26
PT85109A (en) 1987-07-01
AU7455987A (en) 1987-12-24
EP0251625B1 (en) 1991-05-29

Similar Documents

Publication Publication Date Title
DK317287A (da) Hmg-coa-reduktaseinhibitorer samt et farmaceutisk praeparat, der indeholder disse
DE3681991D1 (de) Hmg-coa-reduktase-hemmungskoerper.
DE3676515D1 (de) Intranasal applizierbare pharmazeutische puder.
DK359986D0 (da) Phenylethere, fremgangsmaader til fremstilling samt farmaceutiske midler indeholdende disse
DK164868C (da) Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK304088D0 (da) Krystallinske metalaluminophospater samt en fremg angsmaade til fremstilling heraf
DE68904083D1 (de) Hmg-coa-reduktaseinhibitoren.
DK219387D0 (da) Aminothiazol- og aminooxazolderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DE68901091D1 (de) Hmg-coa-reduktaseinhibitoren.
DK298786A (da) Fiberholdigt produkt samt fremgangsmaade til fremstilling heraf
DE3881373D1 (de) Hmg-coa-reduktase-hemmer.
DK206785A (da) Benzazepinderivater, laegemidler indeholdende disse samt fremgangsmaade til fremstilling deraf
DK165367C (da) Imidazolylalkylguanidinderivater, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse forbindelser
DK66086A (da) Dihydropyridiner, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK486789D0 (da) Benzoxazolinonderivater, fremgangsmaader til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK506386A (da) Flavonderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DE68900988D1 (de) Hmg-coa-reduktase-inhibitoren.
DK114189D0 (da) Benzocycloheptenderivater, samt laegemidler med indhold af saadanne forbindelser
DK307085D0 (da) 4-phenyl-2-trifluormethyl-1,3-dioxan-5-ylheptensyrederivater, fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK553689A (da) Phenyloxypropanolaminderivater, fremgangsmaade til fremstilling af saadanne forbindelser samt laegemiddel indeholdende disse
DK285886A (da) Vasopressinantagonister, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK65986A (da) Dihydropyridiner, fremgangsmaader til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK205590D0 (da) Farmaceutisk nifedipinholdigt praeparat
DK65686D0 (da) Dihydropyridiner, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK501385D0 (da) 1,3,4-thiadiazolderivater, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse forbindelser

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment