DK3139170T3 - Fremgangsmåde til vurdering af om en patient med glioblastoma multiforme er egnet til immunterapibehandling baseret på dendritiske celletumorvacciner - Google Patents

Fremgangsmåde til vurdering af om en patient med glioblastoma multiforme er egnet til immunterapibehandling baseret på dendritiske celletumorvacciner Download PDF

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DK3139170T3
DK3139170T3 DK16169813.9T DK16169813T DK3139170T3 DK 3139170 T3 DK3139170 T3 DK 3139170T3 DK 16169813 T DK16169813 T DK 16169813T DK 3139170 T3 DK3139170 T3 DK 3139170T3
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gbm
patient
dendritic cell
cell tumor
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DK16169813.9T
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Der-Yang Cho
Shao-Chih Chiu
Chia-Ing JAN
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Univ Medical Hospital China
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70517—CD8
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
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  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Claims (5)

  1. FREMGANGSMÅDE TIL VURDERING AF OM EN PATIENT MED GLIOBLASTOMA MULTIFORME ER EGNET TIL IMMUNTERAPIBEHANDLING BASERET PÅ DENDRITISKE CELLETUMORVACCINER
    1. Fremgangsmåde til vurdering af om en patient med glioblastoma multiforme er egnet til at undergå en immunterapibehandling, der er baseret på en dendri-tisk celletumervaccine (100), hvilken fremgangsmåde omfatter: at tilvejebringe en prøve der er opnået fra den glioblastoma-multiforme patient (110), hvilken prøve er et tumorvæv eller blod; at detektere et ekspressionsniveau af PD-1 og et ekspressionsniveau af CD8 og derefter at beregne en basisværdi ved at dividere ekspressionsniveauet af PD-1 med ekspressionsniveauet af CD8 for at danne et forhold (PD-1/CD8-ratio) mellem ekspressionsniveauet af PD-1 til ekspressionsniveau for CD8; og at sammenligne basisværdien med en tærskelværdi (130), hvor, når basisværdien er lavere end tærskelværdien, den glioblastoma-multiforme patient vurderes at være egnet til immunterapibehandling, der er baseret på den dendritiske celletumervaccine.
  2. 2. Fremgangsmåden ifølge krav 1, hvor tumorvævet er en vævssektion eller en vævs-mikroarray.
  3. 3. Fremgangsmåden ifølge krav 1, hvor detektion af ekspressionsniveauerne af PD-1 og CD8 udføres ved immunhistokemi.
  4. 4. Fremgangsmåden ifølge krav 3, hvor detektionen af ekspressionsniveauerne yderligere omfatter at beregne en signalværdi ved en H-score-fremgangsmåde eller en billedbehandlingsfremgangsmåde.
  5. 5. Fremgangsmåden ifølge krav 4, hvor billedbehandlingsfremgangsmåden anvender en RGB (rød/grøn/blå) farvemodel, en CMYK (cyan/magenta/gul/nøgle) farvemodel eller en HSI (farvetone/mætning/intensitet) farvemodel til at analysere et billede af prøven.
DK16169813.9T 2015-08-10 2016-05-16 Fremgangsmåde til vurdering af om en patient med glioblastoma multiforme er egnet til immunterapibehandling baseret på dendritiske celletumorvacciner DK3139170T3 (da)

Applications Claiming Priority (1)

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TW104125986 2015-08-10

Publications (1)

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DK3139170T3 true DK3139170T3 (da) 2019-01-28

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DK16169813.9T DK3139170T3 (da) 2015-08-10 2016-05-16 Fremgangsmåde til vurdering af om en patient med glioblastoma multiforme er egnet til immunterapibehandling baseret på dendritiske celletumorvacciner

Country Status (6)

Country Link
US (1) US10036751B2 (da)
EP (1) EP3139170B1 (da)
JP (1) JP6363652B2 (da)
DK (1) DK3139170T3 (da)
ES (1) ES2699322T3 (da)
TW (1) TWI609183B (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210033599A1 (en) * 2018-04-26 2021-02-04 Nec Corporation Information processing apparatus, control method, and program
US20220180979A1 (en) * 2019-03-15 2022-06-09 3M Innovative Properties Company Adaptive clinical trials

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1777523A1 (en) * 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
CN103796680A (zh) * 2011-06-21 2014-05-14 约翰霍普金斯大学 用于增强针对赘生物的基于免疫的治疗的聚焦放射
JP5906623B2 (ja) * 2011-09-09 2016-04-20 コニカミノルタ株式会社 生体物質発現レベル評価システム
EP3065772A4 (en) * 2013-11-05 2017-09-13 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
US20170175197A1 (en) * 2014-01-29 2017-06-22 Caris Mpi, Inc. Molecular profiling of immune modulators

Also Published As

Publication number Publication date
EP3139170B1 (en) 2018-10-03
EP3139170A2 (en) 2017-03-08
JP2017037059A (ja) 2017-02-16
US10036751B2 (en) 2018-07-31
US20170045516A1 (en) 2017-02-16
TWI609183B (zh) 2017-12-21
JP6363652B2 (ja) 2018-07-25
TW201706601A (zh) 2017-02-16
ES2699322T3 (es) 2019-02-08
EP3139170A3 (en) 2017-05-17

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