DK3122723T3 - Fremgangsmåde til isolering af et carotenoid fra en carotenoidproducerende bioorganisme - Google Patents

Fremgangsmåde til isolering af et carotenoid fra en carotenoidproducerende bioorganisme Download PDF

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Publication number
DK3122723T3
DK3122723T3 DK15712899.2T DK15712899T DK3122723T3 DK 3122723 T3 DK3122723 T3 DK 3122723T3 DK 15712899 T DK15712899 T DK 15712899T DK 3122723 T3 DK3122723 T3 DK 3122723T3
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DK
Denmark
Prior art keywords
carotenoid
solvent
carotenoids
acid
carried out
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DK15712899.2T
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English (en)
Inventor
James Treganowan
Carlos Santos
Julia Kessler
Daniel Grenfell-Lee
Claudia Toniato
Christian Schaefer
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Dsm Ip Assets Bv
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)

Claims (7)

1. Fremgangsmåde til isolering af et carotenoid fra en carotenoidproducerende bioorganisme, som omfatter følgende trin (i) ekstraktion af carotenoidet fra biomassen ved hjælp af mindst ét opløsningsmiddel (I) og (ii) eventuelt mindst ét vasketrin ved anvendelse af mindst ét opløsningsmiddel (II), der er ikke-blandbart med opløsningsmiddel (I), og (iii) eventuelt tørring af den opnåede opløsning, der omfatter carotenoidet, der er kendetegnet ved, at der efter trin (i) udføres mindst ét vasketrin ved anvendelse af en vandig opløsning af en Brønsted-syre (trin (i')), hvor Brønsted-syren er valgt fra gruppen, der består af citronsyre, vinsyre og maleinsyre.
2. Fremgangsmåde ifølge krav 1, hvor koncentrationen af den vandige opløsning af Brønsted-syren er mellem 0,5 og 10 vægt-% baseret på den samlede vægt af den vandige opløsning.
3. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor fremgangsmåden udføres portionsvis eller kontinuerligt.
4. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor ekstraktionen (trin (i)) sædvanligvis udføres ved en temperatur under kogepunktet for opløsningsmidlet.
5. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor ekstraktionen af carotenoidet fra biomassen udføres i mindst ét ikke-vandblandbart opløsningsmiddel.
6. Fremgangsmåde ifølge krav 5, hvor hvor ekstraktionen af carotenoidet fra biomassen udføres i mindst ét opløsningsmiddel valgt fra gruppen, der består af CH2CI2, chloroform, n-heptan og n-hexan.
7. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor der mindst udføres vasketrin (trin (ii)) efter trin (i) og før og/eller efter trin (ii).
DK15712899.2T 2014-03-28 2015-03-26 Fremgangsmåde til isolering af et carotenoid fra en carotenoidproducerende bioorganisme DK3122723T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14162365 2014-03-28
PCT/EP2015/056594 WO2015144831A1 (en) 2014-03-28 2015-03-26 Process for isolating a carotenoid from a carotenoid-producing bioorganism

Publications (1)

Publication Number Publication Date
DK3122723T3 true DK3122723T3 (da) 2018-08-13

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DK15712899.2T DK3122723T3 (da) 2014-03-28 2015-03-26 Fremgangsmåde til isolering af et carotenoid fra en carotenoidproducerende bioorganisme

Country Status (10)

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US (1) US9902692B2 (da)
EP (1) EP3122723B1 (da)
JP (1) JP6593341B2 (da)
CN (1) CN106232578B (da)
BR (1) BR112016022546B8 (da)
CL (1) CL2016002456A1 (da)
DK (1) DK3122723T3 (da)
EA (1) EA031085B1 (da)
ES (1) ES2680471T3 (da)
WO (1) WO2015144831A1 (da)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504067B1 (en) * 1999-11-24 2003-01-07 Industrial Organica S.A. De C.V. Process to obtain xanthophyll concentrates of high purity
CA2396167C (en) * 2000-01-27 2010-01-26 Dsm N.V. Isolation of carotenoid crystals
US6329557B1 (en) * 2000-06-09 2001-12-11 Prodemex, S.A. De C.V. Purification of xanthophylls from marigold extracts that contain high levels of chlorophylls
US7064101B2 (en) * 2001-03-22 2006-06-20 Fuji Chemical Industry Co., Ltd. Stable astaxanthin-containing powdery compositions and process for producing the same
RU2211862C2 (ru) * 2001-10-29 2003-09-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (-) ШТАММ ГЕТЕРОТАЛЛИЧНОГО ФИКОМИЦЕТА Blakeslea trispora, ПРОДУЦИРУЮЩИЙ ЛИКОПИН В ПАРЕ С РАЗНЫМИ (+)ШТАММАМИ Blakeslea trispora, И СПОСОБ МИКРОБИОЛОГИЧЕСКОГО СИНТЕЗА ЛИКОПИНА
US7629007B2 (en) * 2005-12-19 2009-12-08 Industrias Vepinsa, S.A. de C.V. Process for purification of free xanthophylls
US8247615B2 (en) * 2010-05-14 2012-08-21 Kalamazoo Holdings, Inc. Process of converting esterified xanthophylls from Capsicum to non-esterified xanthophylls in high yields and purities
JPWO2011018896A1 (ja) * 2009-08-11 2013-01-17 株式会社カネカ アスタキサンチン含有組成物の製造方法
CN101774955A (zh) * 2009-12-08 2010-07-14 江苏省农业科学院 一种由万寿菊干花颗粒制备高含量反式叶黄素晶体的方法
CN103012230A (zh) * 2013-01-06 2013-04-03 大连医诺生物有限公司 三孢布拉霉菌中类胡萝卜素的高效提取新工艺

Also Published As

Publication number Publication date
US20170129854A1 (en) 2017-05-11
CL2016002456A1 (es) 2017-06-09
ES2680471T3 (es) 2018-09-07
CN106232578A (zh) 2016-12-14
BR112016022546B8 (pt) 2020-12-22
US9902692B2 (en) 2018-02-27
BR112016022546A2 (pt) 2018-06-19
EP3122723A1 (en) 2017-02-01
EP3122723B1 (en) 2018-05-09
BR112016022546B1 (pt) 2020-10-20
CN106232578B (zh) 2019-06-07
EA201691949A8 (ru) 2017-06-30
EA031085B1 (ru) 2018-11-30
JP6593341B2 (ja) 2019-10-23
JP2017516750A (ja) 2017-06-22
WO2015144831A1 (en) 2015-10-01
EA201691949A1 (ru) 2017-02-28

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