DK309479A - Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf - Google Patents

Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf

Info

Publication number
DK309479A
DK309479A DK309479A DK309479A DK309479A DK 309479 A DK309479 A DK 309479A DK 309479 A DK309479 A DK 309479A DK 309479 A DK309479 A DK 309479A DK 309479 A DK309479 A DK 309479A
Authority
DK
Denmark
Prior art keywords
esters
alfadifluormethylaminos
acids
procedure
preparation
Prior art date
Application number
DK309479A
Other languages
Danish (da)
English (en)
Inventor
J Kollonitsch
S Marburg
A A Patchett
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK309479A publication Critical patent/DK309479A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/48Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK309479A 1978-07-24 1979-07-23 Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf DK309479A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92721078A 1978-07-24 1978-07-24

Publications (1)

Publication Number Publication Date
DK309479A true DK309479A (da) 1980-02-19

Family

ID=25454398

Family Applications (1)

Application Number Title Priority Date Filing Date
DK309479A DK309479A (da) 1978-07-24 1979-07-23 Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf

Country Status (6)

Country Link
EP (1) EP0007600B1 (de)
JP (1) JPS5519282A (de)
AT (1) ATE3282T1 (de)
DE (1) DE2965364D1 (de)
DK (1) DK309479A (de)
IE (1) IE49729B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49522B1 (en) * 1979-04-26 1985-10-16 Merrell Toraude & Co Alpha-halomethylaminoacids
ZA813018B (en) * 1980-05-09 1982-05-26 Merrell Toraude & Co Fluoromethylated tyrosine methyl ester
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
EP0451422A1 (de) * 1990-04-13 1991-10-16 Merrell Dow Pharmaceuticals Inc. Pharmazeutisch aktive Fluoromethyltyrosin-Verbindungen
AU2019395020A1 (en) * 2018-12-06 2021-06-17 Senda Biosciences, Inc. Decarboxylase inhibitors for treating Parkinson's disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines
GR64495B (en) * 1977-06-01 1980-03-31 Merck & Co Inc Novel fluorinated amino acids
ZA783273B (en) * 1977-07-11 1979-06-27 Merrell Toraude & Co A-halomethyl amino acids

Also Published As

Publication number Publication date
JPS5519282A (en) 1980-02-09
EP0007600B1 (de) 1983-05-11
DE2965364D1 (en) 1983-06-16
IE791378L (en) 1980-01-24
EP0007600A1 (de) 1980-02-06
ATE3282T1 (de) 1983-05-15
IE49729B1 (en) 1985-12-11

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Legal Events

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AHS Application shelved for other reasons than non-payment