DK2968493T3 - Forbedrede poxvirusvacciner. - Google Patents
Forbedrede poxvirusvacciner. Download PDFInfo
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- DK2968493T3 DK2968493T3 DK14723475.1T DK14723475T DK2968493T3 DK 2968493 T3 DK2968493 T3 DK 2968493T3 DK 14723475 T DK14723475 T DK 14723475T DK 2968493 T3 DK2968493 T3 DK 2968493T3
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Claims (17)
1. Vektor med modificeret vaccinia-virus af Ankara-stammen (MVA), omfattende et nukleinsyrekonstrukt, hvilket nukleinsyrekonstrukt omfatter: (i) en nukleinsyre kodende for mindst ét antigent protein eller antigent fragment deraf, virkningsmæssigt forbundet til (ii) en nukleinsyre kodende for mindst én invariant kæde; hvor den mindst ene invariante kæde har mindst 85 % sekvenssimilaritet med den humane isoform p35 i SEQ ID NO:1, p43 i SEQ ID NO:5 eller c i SEQ ID NO:9 eller en af muse-isoformerne p31 i SEQ ID NO:3 eller p41 i SEQ ID NO:7.
2. MVA-vektor ifølge krav 1, hvor den mindst ene kodede invariante kæde er af pattedyroprindelse.
3. MVA-vektor ifølge enten krav 1 eller 2, hvor den kodede mindst ene invariante kæde er human isoform p35 i SEQ ID NO:1, p43 i SEQ ID NO:5 eller c i SEQ ID NO:9 eller en af museisoformerne p31 i SEQ ID NO:3 eller p41 i SEQ ID NO:7.
4. MVA-vektor ifølge enten krav 1 eller 2, hvor den kodede mindst ene invariante kæde har mindst 90 % sekvenssimilaritet med SEQ ID NO:1 eller SEQ ID NO:3.
5. MVA-vektor ifølge krav 4, hvor den kodede mindst ene invariante kæde har mindst 99 % sekvenssimilaritet med SEQ ID NO:1 eller SEQ ID NO:3.
6. MVA-vektor ifølge et hvilket som helst af kravene 1 til 5, hvor det mindst ene antigene protein er et protein fra en virus, en bakterie, en protist eller en flercellet parasit.
7. MVA-vektor ifølge et hvilket som helst af kravene 1 til 6 til anvendelse i forberedelse eller forstærkning af en immunreaktion.
8. MVA-vektor til anvendelse ifølge krav 7, hvor forberedelsen af immunreaktionen er del af et homologt forberedelses-forstærknings-vaccinationsprogram.
9. MVA-vektor til anvendelse ifølge krav 7, hvor forberedelsen af immunreaktionen er del af et heterologt forberedelses-forstærknings-vaccinationsprogram.
10. Vaccinekombination omfattende: (a) en MVA-vektor omfattende et nukleinsyrekonstrukt, hvor nukleinsyrekonstruktet omfatter: (i) en nukleinsyresekvens kodende for mindst et første antigent protein eller antigent fragment deraf, virkningsmæssigt forbundet til (ii) en nukleinsyre kodende for mindst én invariant kæde, hvor den mindst ene invariante kæde har mindst 85 % sekvenssimilaritet med human isoform p35 i SEQ ID NO:1, p43 i SEQ ID NO:5 eller c i SEQ ID NO:9 eller en af museisoformerne p31 i SEQ ID NO:3 eller p41 i SEQ ID NO:7 og (b) en adenovirusvektor omfattende en nukleinsyresekvens kodende for mindst et andet antigent protein eller antigent fragment deraf, hvor mindst én epitop af det første antigene protein eller antigene fragment deraf genkendes af det samme antistof, T-celle eller B-celle til det andet antigene protein eller fragment deraf.
11. Vaccinekombination ifølge krav 10, hvor den invariante kæde er human isoform p35 i SEQ ID NO:1, p43 i SEQ ID NO:5 eller c i SEQ ID NO:9 eller en af museisoformerne p31 i SEQ ID NO:3 eller p41 i SEQ ID NO:7.
12. Vaccinekombination ifølge krav 10, hvor den invariante kæde har mindst 90 % sekvenssimilaritet med SEQ ID NO:1 eller SEQ ID NO:3.
13. Vaccinekombination ifølge krav 12, hvor den invariante kæde har mindst 99 % sekvenssimilaritet med SEQ ID NO:1 eller SEQ ID NO:3.
14. Vaccinekombination ifølge et hvilket som helst af kravene 10 til 13, hvor adenovirusvektoren er en ikke-human menneskeabe-afledt adenovirusvektor, fortrinsvis en chimpanse- eller bonobo-adenovirusvektor.
15. Vaccinekombination ifølge et hvilket som helst af kravene 10 til 14 til anvendelse i et forberedelses-forstærknings-vaccinationsprogram.
16. MVA-vektor ifølge krav 1 til anvendelse som lægemiddel.
17. MVA-vektor ifølge krav 1 til anvendelse i stimulering af en immunreaktion hos et individ.
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WO2017025782A1 (en) * | 2014-09-17 | 2017-02-16 | Glaxosmithkline Biologicals Sa | Improved poxviral vaccines |
JP6893177B2 (ja) | 2015-05-15 | 2021-06-23 | キュアバック アーゲー | 少なくとも1つのmRNAコンストラクトの投与を含むプライムブーストレジメン(PRIME−BOOST REGIMENS) |
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GB201704417D0 (en) | 2017-03-20 | 2017-05-03 | Univ Copenhagen | Improved li vaccine adjuvant |
EP3651798A1 (en) * | 2017-07-12 | 2020-05-20 | Nouscom AG | Neoantigen vaccine composition for treatment of cancer |
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PL1957528T3 (pl) | 2005-11-30 | 2013-03-29 | Univ Copenhagen | Szczepionka nukleotydowa |
RU2011125306A (ru) * | 2008-11-21 | 2012-12-27 | Юнивёрсити Оф Копенгаген | Праймирование иммунного ответа |
KR101763093B1 (ko) | 2009-02-02 | 2017-07-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
WO2014139587A1 (en) | 2013-03-15 | 2014-09-18 | Okairòs Ag | Improved poxviral vaccines |
US10576143B2 (en) * | 2013-03-15 | 2020-03-03 | Glaxosmithkline Biologicals Sa | Poxviral vaccines |
GB201321384D0 (en) | 2013-12-04 | 2014-01-15 | Isis Innovation | Molecular adjuvant |
MX2019002178A (es) | 2016-08-23 | 2019-09-18 | Glaxosmithkline Biologicals Sa | Peptidos de fusion con antigenos enlazados a fragmentos cortos de cadena invariante (cd74). |
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2013
- 2013-03-15 WO PCT/EP2013/055409 patent/WO2014139587A1/en active Application Filing
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2014
- 2014-03-14 JP JP2015562528A patent/JP6702725B2/ja active Active
- 2014-03-14 SI SI201430827T patent/SI2968493T1/sl unknown
- 2014-03-14 CN CN201811100700.2A patent/CN109182378A/zh active Pending
- 2014-03-14 HU HUE14723475A patent/HUE040189T2/hu unknown
- 2014-03-14 CA CA2907026A patent/CA2907026A1/en active Pending
- 2014-03-14 BE BE2014/0166A patent/BE1021192B1/fr not_active IP Right Cessation
- 2014-03-14 WO PCT/IB2014/059802 patent/WO2014141176A1/en active Application Filing
- 2014-03-14 ES ES14723475.1T patent/ES2685922T3/es active Active
- 2014-03-14 CN CN201480015680.2A patent/CN105307674A/zh active Pending
- 2014-03-14 BR BR112015023524-7A patent/BR112015023524B1/pt active IP Right Grant
- 2014-03-14 DK DK14723475.1T patent/DK2968493T3/da active
- 2014-03-14 PT PT14723475T patent/PT2968493T/pt unknown
- 2014-03-14 US US14/770,510 patent/US20160000904A1/en not_active Abandoned
- 2014-03-14 LT LTEP14723475.1T patent/LT2968493T/lt unknown
- 2014-03-14 PL PL14723475T patent/PL2968493T3/pl unknown
- 2014-03-14 EP EP14723475.1A patent/EP2968493B1/en active Active
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2017
- 2017-12-20 US US15/848,100 patent/US10588961B2/en active Active
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- 2018-08-28 HR HRP20181376TT patent/HRP20181376T1/hr unknown
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Also Published As
Publication number | Publication date |
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CN105307674A (zh) | 2016-02-03 |
EP2968493B1 (en) | 2018-06-13 |
US11278614B2 (en) | 2022-03-22 |
WO2014139587A1 (en) | 2014-09-18 |
BR112015023524B1 (pt) | 2023-10-31 |
US20200164061A1 (en) | 2020-05-28 |
US20160000904A1 (en) | 2016-01-07 |
JP2016510989A (ja) | 2016-04-14 |
BE1021192B1 (fr) | 2016-10-21 |
US20180125968A1 (en) | 2018-05-10 |
PT2968493T (pt) | 2018-10-03 |
JP6702725B2 (ja) | 2020-06-03 |
CN109182378A (zh) | 2019-01-11 |
SI2968493T1 (sl) | 2018-12-31 |
PL2968493T3 (pl) | 2018-11-30 |
CY1120740T1 (el) | 2019-12-11 |
ES2685922T3 (es) | 2018-10-15 |
US10588961B2 (en) | 2020-03-17 |
WO2014141176A1 (en) | 2014-09-18 |
LT2968493T (lt) | 2018-09-10 |
HRP20181376T1 (hr) | 2018-10-19 |
BR112015023524A2 (pt) | 2017-10-24 |
EP2968493A1 (en) | 2016-01-20 |
CA2907026A1 (en) | 2014-09-18 |
HUE040189T2 (hu) | 2019-02-28 |
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