DK2920196T3 - Binding af cysteinrester under anvendelse af cykliske disulfider - Google Patents
Binding af cysteinrester under anvendelse af cykliske disulfider Download PDFInfo
- Publication number
- DK2920196T3 DK2920196T3 DK13854478.8T DK13854478T DK2920196T3 DK 2920196 T3 DK2920196 T3 DK 2920196T3 DK 13854478 T DK13854478 T DK 13854478T DK 2920196 T3 DK2920196 T3 DK 2920196T3
- Authority
- DK
- Denmark
- Prior art keywords
- binding
- cystein residues
- cyclic disulfides
- disulfides
- cyclic
- Prior art date
Links
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title 1
- 150000002019 disulfides Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261726776P | 2012-11-15 | 2012-11-15 | |
| PCT/US2013/070239 WO2014078623A2 (en) | 2012-11-15 | 2013-11-15 | Tethering cysteine residues using cyclic disulfides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2920196T3 true DK2920196T3 (da) | 2021-06-14 |
Family
ID=50731827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13854478.8T DK2920196T3 (da) | 2012-11-15 | 2013-11-15 | Binding af cysteinrester under anvendelse af cykliske disulfider |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9428589B2 (da) |
| EP (1) | EP2920196B1 (da) |
| JP (2) | JP6480340B2 (da) |
| CA (1) | CA2891261C (da) |
| DK (1) | DK2920196T3 (da) |
| WO (1) | WO2014078623A2 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6480340B2 (ja) * | 2012-11-15 | 2019-03-06 | ブランデイズ ユニバーシティー | 環状ジスルフィドを用いるシステイン残基のテザリング |
| EA201591049A1 (ru) | 2012-11-30 | 2015-09-30 | Новартис Аг | Способы получения конъюгатов дисульфидсодержащих белков |
| ES2729643T3 (es) | 2013-11-26 | 2019-11-05 | Novartis Ag | Métodos para la conjugación de oxima con polipéptidos modificados con cetona |
| CN105535983B (zh) * | 2014-05-28 | 2018-04-24 | 博瑞生物医药（苏州）股份有限公司 | 一种侧链含双硫五元环功能基团的碳酸酯聚合物在制备药物控制释放载体中的应用 |
| CN104004001B (zh) * | 2014-05-28 | 2016-03-30 | 苏州大学 | 含双硫五元环功能基团的环状碳酸酯单体及其制备方法 |
| US10711261B2 (en) | 2015-08-18 | 2020-07-14 | Brandeis University | Tethering cysteine residues using cyclic disulfides |
| MA46205A (fr) | 2016-09-08 | 2019-07-17 | Sabila Biosciences Llc | Composés 1,2-dithiolane utiles dans la neuroprotection, les maladies et les états auto-immuns et cancéreux |
| IT201600101413A1 (it) | 2016-10-10 | 2018-04-10 | Sofar Swiss S A | Composizione liquida per uso nel trattamento del reflusso gastroesofageo |
| WO2019014311A1 (en) * | 2017-07-11 | 2019-01-17 | Northeastern University | HETEROCYCLIC DITHIOL CLICK CHEMISTRY |
| CA3097104A1 (en) | 2018-04-19 | 2019-10-24 | Stichting Vu | Protein macrocyclization |
| JP7512207B2 (ja) * | 2018-05-24 | 2024-07-08 | サーナオミクス インコーポレイテッド | 核酸治療薬のための調節可能な共カップリングポリペプチドナノ粒子送達系の組成物および方法 |
| WO2024177503A1 (en) * | 2023-02-21 | 2024-08-29 | Stichting Vu | Stabilized native protein complexes conjugated with branched molecules |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2260128A1 (en) * | 1996-07-05 | 1998-01-15 | William G. Rice | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
| CZ96798A3 (cs) * | 1997-04-02 | 1998-10-14 | Sankyo Company Limited | Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky |
| WO2005075513A1 (ja) * | 2004-02-04 | 2005-08-18 | National Institute Of Advanced Industrial Science And Technology | システイン残基が酸化されたdj-1誘導体 |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| JP5792715B2 (ja) | 2009-06-02 | 2015-10-14 | ブランデイス ユニヴァーシティー | スーパーオキシドジスムターゼモノマーの架橋 |
| PL2442647T3 (pl) | 2009-06-15 | 2016-09-30 | Związki ditiolowe, pochodne i ich zastosowania | |
| JP6480340B2 (ja) | 2012-11-15 | 2019-03-06 | ブランデイズ ユニバーシティー | 環状ジスルフィドを用いるシステイン残基のテザリング |
-
2013
- 2013-11-15 JP JP2015542801A patent/JP6480340B2/ja active Active
- 2013-11-15 WO PCT/US2013/070239 patent/WO2014078623A2/en active Application Filing
- 2013-11-15 DK DK13854478.8T patent/DK2920196T3/da active
- 2013-11-15 US US14/440,978 patent/US9428589B2/en active Active
- 2013-11-15 CA CA2891261A patent/CA2891261C/en active Active
- 2013-11-15 EP EP13854478.8A patent/EP2920196B1/en active Active
-
2016
- 2016-07-26 US US15/219,807 patent/US9944919B2/en active Active
-
2018
- 2018-03-05 US US15/912,197 patent/US10689639B2/en active Active
-
2019
- 2019-02-07 JP JP2019020738A patent/JP2019104743A/ja active Pending
-
2020
- 2020-05-22 US US16/882,035 patent/US11254923B2/en active Active
-
2022
- 2022-01-13 US US17/574,742 patent/US11987827B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9428589B2 (en) | 2016-08-30 |
| US20150284478A1 (en) | 2015-10-08 |
| CA2891261A1 (en) | 2014-05-22 |
| CA2891261C (en) | 2023-04-04 |
| EP2920196A4 (en) | 2016-06-01 |
| US11987827B2 (en) | 2024-05-21 |
| EP2920196B1 (en) | 2021-03-31 |
| US11254923B2 (en) | 2022-02-22 |
| US20220135961A1 (en) | 2022-05-05 |
| US9944919B2 (en) | 2018-04-17 |
| US20160333336A1 (en) | 2016-11-17 |
| US20200283753A1 (en) | 2020-09-10 |
| WO2014078623A2 (en) | 2014-05-22 |
| EP2920196A2 (en) | 2015-09-23 |
| WO2014078623A3 (en) | 2014-07-10 |
| JP2019104743A (ja) | 2019-06-27 |
| JP2015536346A (ja) | 2015-12-21 |
| US10689639B2 (en) | 2020-06-23 |
| US20180245063A1 (en) | 2018-08-30 |
| JP6480340B2 (ja) | 2019-03-06 |
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