DK2892649T3 - Forbedringer vedrørende kapillærtrykbarrierer - Google Patents

Forbedringer vedrørende kapillærtrykbarrierer Download PDF

Info

Publication number
DK2892649T3
DK2892649T3 DK13766404.1T DK13766404T DK2892649T3 DK 2892649 T3 DK2892649 T3 DK 2892649T3 DK 13766404 T DK13766404 T DK 13766404T DK 2892649 T3 DK2892649 T3 DK 2892649T3
Authority
DK
Denmark
Prior art keywords
capillary pressure
pressure barriers
improvements concerning
concerning
barriers
Prior art date
Application number
DK13766404.1T
Other languages
English (en)
Inventor
Paul Vulto
Sebastiaan Johannes Trietsch
Ender Yildirim
Original Assignee
Univ Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leiden filed Critical Univ Leiden
Application granted granted Critical
Publication of DK2892649T3 publication Critical patent/DK2892649T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK13766404.1T 2012-09-10 2013-09-10 Forbedringer vedrørende kapillærtrykbarrierer DK2892649T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1216118.8A GB2505706A (en) 2012-09-10 2012-09-10 Apparatus comprising meniscus alignment barriers
NL2011280A NL2011280C2 (en) 2012-09-10 2013-08-07 Improvements relating to capillary pressure barriers.
PCT/NL2013/050650 WO2014038943A1 (en) 2012-09-10 2013-09-10 Improvements relating to capillary pressure barriers

Publications (1)

Publication Number Publication Date
DK2892649T3 true DK2892649T3 (da) 2021-11-01

Family

ID=47137195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13766404.1T DK2892649T3 (da) 2012-09-10 2013-09-10 Forbedringer vedrørende kapillærtrykbarrierer

Country Status (8)

Country Link
US (1) US11344877B2 (da)
EP (1) EP2892649B1 (da)
JP (3) JP2015530240A (da)
CN (2) CN105026045A (da)
DK (1) DK2892649T3 (da)
GB (1) GB2505706A (da)
NL (2) NL2011280C2 (da)
WO (1) WO2014038943A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
GB2505706A (en) * 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
US11504645B2 (en) * 2013-06-19 2022-11-22 Universiteit Leiden Two-phase electroextraction from moving phases
WO2015019336A2 (en) 2013-08-08 2015-02-12 Universiteit Leiden Fluid triggable valves
EP3009189A1 (en) * 2014-10-16 2016-04-20 Commissariat A L'energie Atomique Et Aux Energies Alternatives Microfluid device including a flow-regulating chamber
CN107847929B (zh) 2015-06-05 2020-08-11 米梅塔斯私人有限公司 微流体板
NL2015130B1 (en) 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
NL2015854B1 (en) 2015-11-26 2017-06-13 Mimetas B V Apparatus for Inducing Microfluidic Flow.
CA3012680A1 (en) 2016-01-29 2017-08-03 Purigen Biosystems, Inc. Isotachophoresis for purification of nucleic acids
NL2016404B1 (en) 2016-03-09 2017-09-26 Mimetas B V Double tubular structures.
JP6868036B2 (ja) * 2016-04-14 2021-05-12 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． 毛細管室を有するマイクロ流体デバイス
AU2017286096B2 (en) 2016-06-15 2022-01-20 Mimetas B.V. Cell culture device and methods
SG11202000871WA (en) * 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
JP6939415B2 (ja) * 2017-10-27 2021-09-22 ウシオ電機株式会社 マイクロチップ
US11198128B2 (en) * 2018-09-05 2021-12-14 International Business Machines Corporation Microfluidic device with array of chambers for encoding detectable information
NL2022085B1 (en) 2018-11-28 2020-06-25 Mimetas B V Device for assessing mechanical strain induced in or by cells
NL2024202B1 (en) 2019-11-08 2021-07-20 Mimetas B V Microfluidic cell culture system
NL2026038B1 (en) 2020-07-09 2022-03-15 Mimetas B V Microfluidic cell culture device
NL2028424B1 (en) 2021-06-10 2022-12-20 Mimetas B V Method and apparatus for forming a microfluidic gel structure
IL314493A (en) 2022-01-28 2024-09-01 Glaxosmithkline Ip Dev Ltd A high-throughput assay for cell migration, chemotaxis and function
WO2023161280A1 (en) 2022-02-23 2023-08-31 Technische Universiteit Delft Device for dosing a liquid, and method of use
DE102022209416B3 (de) * 2022-09-09 2023-12-21 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung
NL2034328B1 (en) 2023-03-13 2024-09-24 Mimetas B V Liver vasculature
WO2024191299A1 (en) 2023-03-13 2024-09-19 Mimetas B.V. Liver vasculature

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US5007511A (en) 1989-11-02 1991-04-16 Dana Corporation Bi-directional back stopping clutch
WO2000022436A1 (en) * 1998-10-13 2000-04-20 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
SE0001790D0 (sv) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
US8231845B2 (en) 2000-10-25 2012-07-31 Steag Microparts Structures for uniform capillary flow
AU2003219775A1 (en) 2002-02-15 2003-09-09 President And Fellows Of Harvard College Fluidics systems including magnetic or electric fields and methods of using the same
CN100475317C (zh) * 2003-09-04 2009-04-08 阿尔利克斯公司 利用激光操纵进行基于多层流的颗粒和细胞分离
JP4555609B2 (ja) * 2004-05-21 2010-10-06 東亜ディーケーケー株式会社 気液反応ユニットおよび分析装置
JP4555610B2 (ja) * 2004-05-21 2010-10-06 東亜ディーケーケー株式会社 気液反応ユニットおよび分析装置
US20060002817A1 (en) 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
WO2006061025A2 (en) 2004-12-09 2006-06-15 Inverness Medical Switzerland Gmbh A method of producing a micro fluidic device and a micro fluidic device
CA2610294C (en) * 2005-05-09 2023-10-03 Theranos, Inc. Point-of-care fluidic systems and uses thereof
KR101306214B1 (ko) * 2005-10-24 2013-09-09 미쓰이 가가쿠 가부시키가이샤 마이크로칩 디바이스
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
DE102006050871B4 (de) * 2006-10-27 2011-06-01 Albert-Ludwigs-Universität Freiburg Integriertes mikrofluidisches Bauteil zum Aufreinigen von Analytmolekülen sowie Verfahren zum Aufreinigen
WO2008105308A1 (ja) * 2007-02-27 2008-09-04 Konica Minolta Holdings, Inc. 流路切換システム
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
BRPI1006723A2 (pt) 2009-04-09 2017-10-10 Koninl Philips Electronics Nv equipamento para produzir camadas de um fluido, método para preparar camadas de um fluido que contém células, método de equipamento de fabricação para produzir camadas de um fluido que contém células, sistema de análise e método para analisar camadas de um fluido que contém células
EP2479466A1 (en) * 2011-01-21 2012-07-25 Biocartis SA Micro-Pump or normally-off micro-valve
JP5901121B2 (ja) * 2011-02-16 2016-04-06 キヤノン株式会社 流路デバイス、及び該流路デバイスを用いた液体の搬送方法
GB201103917D0 (en) * 2011-03-08 2011-04-20 Univ Leiden Apparatus for and methods of processing liquids or liquid based substances
US9083075B2 (en) * 2011-08-04 2015-07-14 Texas Instruments Incorporated First coupling transformer secondary winding coupling second transmitter to antenna
GB2505706A (en) * 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
GB2526999B (en) * 2013-03-14 2020-02-19 Univ Leland Stanford Junior Capillary barriers for staged loading of microfluidic devices

Also Published As

Publication number Publication date
NL2011280A (en) 2014-03-12
JP2021184986A (ja) 2021-12-09
CN113304787A (zh) 2021-08-27
US11344877B2 (en) 2022-05-31
NL2011280C2 (en) 2014-06-17
EP2892649B1 (en) 2021-07-28
WO2014038943A1 (en) 2014-03-13
GB2505706A (en) 2014-03-12
US20150238952A1 (en) 2015-08-27
EP2892649A1 (en) 2015-07-15
JP2015530240A (ja) 2015-10-15
NL2011285C2 (en) 2015-02-10
CN105026045A (zh) 2015-11-04
JP2019022887A (ja) 2019-02-14
GB201216118D0 (en) 2012-10-24
JP6912431B2 (ja) 2021-08-04

Similar Documents

Publication Publication Date Title
FR23C1020I2 (fr) Conjugues pyrrolobenzodiazepine-anticorps
NL301079I2 (nl) isatuximab
DK2892649T3 (da) Forbedringer vedrørende kapillærtrykbarrierer
DK2906251T3 (da) Pyrrolobenzodiazepin-anti-CD22-antistofkonjugater
BR112015008232A2 (pt) conjugados pirrolbenzodiazepina-anticorpo
DK2859055T3 (da) Polymercoatings
DK2825087T3 (da) Otoscanner
DK2839013T3 (da) Ikke-disruptiv-gen-targetering
DK2873977T3 (da) Dobbeltdækker-rørdispenser
DK2854722T3 (da) Stomipose
DE112012006109A5 (de) Okklusionsschienenanordnung
DE102013100889B8 (de) Druckdetektor
DK2825157T3 (da) Aminosyrelipider
DK2831122T3 (da) Anthocyanidin-kompleks
BR112014000262A2 (pt) microviscosímetro capilar
DE112012006214T8 (de) Wulstringwickler
DE112012005566T8 (de) Seltenerdnanoverbundmagnet
FI20126082A (fi) Kaasunvaihtoventtiilijärjestely
DK2877409T3 (da) Væskebeholder
DK2885638T3 (da) Molekylenet
FI20126157A (fi) Laajentumistila
FI20125844A (fi) Talotekniikkamoduuli
ES1077590Y (es) Columbario
DE102013212400A8 (de) Abdeckplattenstützbaugruppe
FI20126108A (fi) Pankkorakenne